Essential Staphylococcus aureus toxin export system

Nature Medicine

Volumn 19, Issue 3, 2013, Pages 364-367

  Chatterjee, Som S ^a   Joo, Hwang Soo ^a   Duong, Anthony C ^a   Dieringer, Thomas D ^a   Tan, Vee Y ^a   Song, Yan ^b   Fischer, Elizabeth R ^c   Cheung, Gordon Y C ^a   Li, Min ^b   Otto, Michael ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b FUDAN UNIVERSITY   (China)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; BACTERIAL PROTEIN; BACTERIAL TOXIN; PHENOL SOLUBLE MODULIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL VIRULENCE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL TOXINS; HUMANS; MICE; NEUTROPHILS; PHENOTYPE; STAPHYLOCOCCAL SKIN INFECTIONS; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 84875227539     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3047     Document Type: Article

References (35)

1. Lowy, F.D. Antimicrobial resistance: the example of Staphylococcus aureus. J. Clin. Invest. 111, 1265-1273 (2003).
2. Alksne, L.E. & Projan, S.J. Bacterial virulence as a target for antimicrobial chemotherapy. Curr. Opin. Biotechnol. 11, 625-636 (2000).
3. Wang, R. et al. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat. Med. 13, 1510-1514 (2007).
4. Wang, R. et al. Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. J. Clin. Invest. 121, 238-248 (2011).
5. Kretschmer, D. et al. Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus. Cell Host Microbe 7, 463-473 (2010).
6. Kobayashi, S.D. et al. Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J. Infect. Dis. 204, 937-941 (2011).
7. Cheung, G.Y. et al. Staphylococcus epidermidis strategies to avoid killing by human neutrophils. PLoS Pathog. 6, e1001133 (2010).
8. Cheung, G.Y., Duong, A.C. & Otto, M. Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins: implications for diagnosis and pathogenesis. Microbes Infect. 14, 380-386 (2012).
9. Periasamy, S. et al. How Staphylococcus aureus biofilms develop their characteristic structure. Proc. Natl. Acad. Sci. USA 109, 1281-1286 (2012).
10. Schwartz, K., Syed, A.K., Stephenson, R.E., Rickard, A.H. & Boles, B.R. Functional amyloids composed of phenol soluble modulins stabilize Staphylococcus aureus biofilms. PLoS Pathog. 8, e1002744 (2012).
11. Rautenberg, M., Joo, H.S., Otto, M. & Peschel, A. Neutrophil responses to staphylococcal pathogens and commensals via the formyl peptide receptor 2 relates to phenol-soluble modulin release and virulence. FASEB J. 25, 1254-1263 (2011).
12. Peterson, M.M. et al. Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection. Cell Host Microbe 4, 555-566 (2008).
13. Rothfork, J.M. et al. Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense. Proc. Natl. Acad. Sci. USA 101, 13867-13872 (2004).
14. Surewaard, B.G. et al. Inactivation of staphylococcal phenol soluble modulins by serum lipoprotein particles. PLoS Pathog. 8, e1002606 (2012).
15. Forsman, H., Christenson, K., Bylund, J. & Dahlgren, C. Receptor-dependent and-independent immunomodulatory effects of phenol-soluble modulin peptides from Staphylococcus aureus on human neutrophils are abrogated through peptide inactivation by reactive oxygen species. Infect. Immun. 80, 1987-1995 (2012).
16. Mehlin, C., Headley, C.M. & Klebanoff, S.J. An inflammatory polypeptide complex from Staphylococcus epidermidis: isolation and characterization. J. Exp. Med. 189, 907-918 (1999).
17. Vuong, C. et al. Regulated expression of pathogen-associated molecular pattern molecules in Staphylococcus epidermidis: quorum-sensing determines pro-inflammatory capacity and production of phenol-soluble modulins. Cell Microbiol. 6, 753-759 (2004).
18. Yao, Y., Sturdevant, D.E. & Otto, M. Genomewide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into the pathophysiology of S. epidermidis biofilms and the role of phenol-soluble modulins in formation of biofilms. J. Infect. Dis. 191, 289-298 (2005).
19. Queck, S.Y. et al. RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol. Cell 32, 150-158 (2008).
20. Cheung, G.Y., Wang, R., Khan, B.A., Sturdevant, D.E. & Otto, M. Role of the accessory gene regulator agr in community-associated methicillin- resistant Staphylococcus aureus pathogenesis. Infect. Immun. 79, 1927-1935 (2011).
21. Otto, M. Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus. Annu. Rev. Microbiol. 64, 143-162 (2010).
22. Zolnerciks, J.K., Andress, E.J., Nicolaou, M. & Linton, K.J. Structure of ABC transporters. Essays Biochem. 50, 43-61 (2011).
23. Walker, J.E., Saraste, M., Runswick, M.J. & Gay, N.J. Distantly related sequences in the α-and β-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1, 945-951 (1982).
24. Otto, M. Staphylococcus epidermidis-the 'accidental' pathogen. Nat. Rev. Microbiol. 7, 555-567 (2009).
25. Cogen, A.L. et al. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J. Invest. Dermatol. 130, 192-200 (2010).
26. Joo, H.S., Cheung, G.Y. & Otto, M. Antimicrobial activity of community-associated methicillin-resistant Staphylococcus aureus is caused by phenol-soluble modulin derivatives. J. Biol. Chem. 286, 8933-8940 (2011).
27. Malachowa, N. et al. Global changes in Staphylococcus aureus gene expression in human blood. PLoS ONE 6, e18617 (2011).
28. Lowy, F.D. Staphylococcus aureus infections. N. Engl. J. Med. 339, 520-532 (1998).
29. Dorschner, R.A. et al. The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides. FASEB J. 20, 35-42 (2006).
30. Wells, J.M., Wilson, P.W. & Le Page, R.W. Improved cloning vectors and transformation procedure for Lactococcus lactis. J. Appl. Bacteriol. 74, 629-636 (1993).
31. Augustin, J. & Gotz, F. Transformation of Staphylococcus epidermidis and other staphylococcal species with plasmid DNA by electroporation. FEMS Microbiol. Lett. 54, 203-207 (1990).
32. Bae, T. & Schneewind, O. Allelic replacement in Staphylococcus aureus with inducible counter-selection. Plasmid 55, 58-63 (2006).
33. Vandecasteele, S.J., Peetermans, W.E., Merckx, R., Van Ranst, M. & Van Eldere, J. Use of gDNA as internal standard for gene expression in staphylococci in vitro and in vivo. Biochem. Biophys. Res. Commun. 291, 528-534 (2002).
34. Li, M. et al. The antimicrobial peptide-sensing system aps of Staphylococcus aureus. Mol. Microbiol. 66, 1136-1147 (2007).
35. Li, M. et al. Gram-positive three-component antimicrobial peptide-sensing system. Proc. Natl. Acad. Sci. USA 104, 9469-9474 (2007).