Regulated expression of pathogen-associated molecular pattern molecules in Staphylococcus epidermis: Quorum-sensing determines pro-inflammatory capacity and production of phenol-soluble modulins

Cellular Microbiology

Volumn 6, Issue 8, 2004, Pages 753-759

  Vuong, Cuong ^a   Dürr, Manuela ^b   Carmondy, Aaron B ^a   Peschel, Andreas ^b   Klebanoff, Seymour J ^c   Otto, Michael ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; PEPTIDE; PHENOL SOLUBLE MODULIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADAPTATION; ANALYTIC METHOD; ARTICLE; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BONE MARROW CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; GENE CONTROL; GENE MUTATION; HOST RESISTANCE; HUMAN; HUMAN CELL; INFLAMMATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; STAPHYLOCOCCUS EPIDERMIDIS; WILD TYPE;

BACTERIAL TOXINS; CHROMATOGRAPHY, LIQUID; HUMANS; INFLAMMATION; MASS SPECTROMETRY; MUTATION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS EPIDERMIDIS; VIRULENCE;

STAPHYLOCOCCUS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 3943050747     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2004.00401.x     Document Type: Article

References (26)

1. Abdelnour, A., Arvidson, S., Bremell, T., Ryden, C., and Tarkowski, A. (1993) The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect Immun 61: 3879-3885.
2. Anonymous (1998) National Nosocomial Surveillance System Report. Atlanta, GA: Center for Disease Control and Prevention.
3. Balaban, N., and Novick, R.P. (1995) Translation of RNAIII, the Staphylococcus aureus agr regulatory RNA molecule, can be activated by a-3′-end deletion. FEMS Microbiol Lett 133: 155-161.
4. Demain, A.L. (1998) Induction of microbial secondary metabolism. Int Microbiol 1: 259-264.
5. Donvito, B., Etienne, J., Denoroy, L., Greenland, T., Benito, Y., and Vandenesch, F. (1997) Synergistic hemolytic activity of Staphylococcus lugdunensis is mediated by three peptides encoded by a non-agr genetic locus. Infect Immun 65: 95-100.
6. Galdbart, J.O., Morvan, A., Desplaces, N., and el Solh, N. (1999) Phenotypic and genomic variation among Staphylococcus epidermidis strains infecting joint prostheses. J Clin Microbiol 37: 1306-1312.
7. Galdbart, J.O., Allignet, J., Tung, H.S., Ryden, C., and El Solh, N. (2000) Screening for Staphylococcus epidermidis markers discriminating between skin-flora strains and those responsible for infections of joint prostheses. J Infect Dis 182: 351-355.
8. Henderson, B., Poole, S., and Wilson, M. (1996) Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis. Microbiol Rev 60: 316-341.
9. Heyer, G., Saba, S., Adamo, R., Rush, W., Soong, G., Cheung, A., and Prince, A. (2002) Staphylococcus aureus agr and sarA functions are required for invasive infection but not inflammatory responses in the lung. Infect Immun 70: 127-133.
10. Janeway, C.A. Jr and Medzhitov, R. (2002) Innate immune recognition. Annu Rev Immunol 20: 197-216.
11. Johnson, G.M., Lee, D.A., Regelmann, W.E., Gray, E.D., Peters, G., and Quie, P.G. (1986) Interference with granulocyte function by Staphylococcus epidermidis slime. Infect Immun 54: 13-20.
12. Klebanoff, S.J., Kazazi, F., Van Voorhis, W.C., and Schlechte, K.G. (1994) Activation of the human immunodeficiency virus long terminal repeat in THP-1 cells by a staphylococcal extracellular product. Proc Natl Acad Sci USA 91: 10615-10619.
13. Liles, W.C., Thomsen, A.R., O'Mahony, D.S., and Klebanoff, S.J. (2001) Stimulation of human neutrophils and monocytes by staphylococcal phenol-soluble modulin. J Leukoc Biol 70: 96-102.
14. Mack, D., Nedelmann, M., Krokotsch, A., Schwarzkopf, A., Heesemann, J., and Laufs, R. (1994) Characterization of transposon mutants of biofilm-producing Staphylococcus epidermidis impaired in the accumulative phase of biofilm production: genetic identification of a hexosamine-containing polysaccharide intercellular adhesin. Infect Immun 62: 3244-3253.
15. Mehlin, C., Headley, C.M., and Klebanoff, S.J. (1999) An inflammatory polypeptide complex from Staphylococcus epidermidis: isolation and characterization. J Exp Med 189: 907-918.
16. Novick, R.P., Ross, H.F., Projan, S.J., Kornblum, J., Kreiswirth, B., and Moghazeh, S. (1993) Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. Embo J 12: 3967-3975.
17. Otto, M., and Götz, F. (2000) Analysis of quorum sensing activity in staphylococci by RP-HPLC of staphylococcal delta-toxin. Biotechniques 28: 1088,1090, 1092, 1096.
18. Troelstra, A., Giepmans, B.N., Van Kessel, K.P., Lichenstein, H.S., Verhoef, J., and Van Strijp, J.A. (1997) Dual effects of soluble CD14 on LPS priming of neutrophils. J Leukoc Biol 61: 173-178.
19. Veldkamp, K.E., Heezius, H.C., Verhoef, J., van Strijp, J.A., and van Kessel, K.P. (2000) Modulation of neutrophil chemokine receptors by Staphylococcus aureus supernate. Infect Immun 68: 5908-5913.
20. Verhoef, J. (1997) Host defense against infection. In The Staphylococci in Human Disease. Archer, G.L., (ed.). New York, NY: Churchill Livingstone, pp. 213-232.
21. Vuong, C., and Otto, M. (2002) Staphylococcus epidermidis infections. Microbes Infect 4: 481-489.
22. Vuong, C., Götz, F., and Otto, M. (2000) Construction and characterization of an agr deletion mutant of Staphylococcus epidermidis. Infect Immun 68: 1048-1053.
23. Vuong, C., Gerke, C., Somerville, G.A., Fischer, E.R., and Otto, M. (2003) Quorum-Sensing control of biofilm factors in Staphylococcus epidermidis. J Infect Dis 188: 706-718.
24. Watson, D.C., Yaguchi, M., Bisaillon, J.G., Beaudet, R., and Morosoli, R. (1988) The amino acid sequence of a gonococcal growth inhibitor from Staphylococcus haemolyticus. Biochem J 252: 87-93.
25. Weiss, J., Bayer, A.S., and Yeaman, M. (2000) Cellular and extracellular defenses against staphylococcal infections. In Gram-Positive Pathogens. Rood, J.I., (ed.). Washington, DC: American Society for Microbiology Press, pp. 431-441.
26. Zhou, N.E., Mant, C.T., and Hodges, R.S. (1990) Effect of preferred binding domains on peptide retention behavior in reversed-phase chromatography: amphipathic alphahelices. Pept Res 3: 8-20.