Mesothelioma with signet-ring cell features: Report of 23 cases

Modern Pathology

Volumn 26, Issue 3, 2013, Pages 370-384

  Ordóñez, Nelson G ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

electron microscopy; immunohistochemistry; signet ring cell carcinoma; signet ring cell mesothelioma

Indexed keywords

CALRETININ; CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 5; CYTOKERATIN 6; CYTOKERATIN 7; MESOTHELIN; NAPSIN A; PODOPLANIN; TRANSCRIPTION FACTOR CDX2; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CELL STRUCTURE; CLINICAL ARTICLE; DECORTICATION; DIFFERENTIAL DIAGNOSIS; ELECTRON MICROSCOPY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG RESECTION; MALE; MESOTHELIOMA; PERITONEUM CANCER; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNET RING CARCINOMA; SIGNET RING CELL MESOTHELIOMA;

ADENOCARCINOMA; ADULT; AGED; CARCINOMA, SIGNET RING CELL; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC ERRORS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MESOTHELIOMA; MICROSCOPY, ELECTRON; MIDDLE AGED; NEOPLASMS, COMPLEX AND MIXED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84875222293     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2012.172     Document Type: Article

References (69)

1. Hammar SP, Henderson DW, Klebe S, et al. Neoplasms of the pleura, In: Tomashefski JF, Cagle PT, Farver CF, Fraire AE(eds) Dail and Hammar's Pulmonary Pathology, Vol. II. Neoplastic Lung Diseases, 3rd edn. Springer Science\+Business Media: New York, NY; 2008, pp 558-734.
2. Kish JK, Ro JY, Ayala AG, et al. Primary mucinous adenocarcinoma of the lung with signet-ring cells: a histochemical comparison with signet-ring cell carcinomas of other sites. Hum Pathol 1989;20:1097-1102.
3. Hayashi H, Kitamura H, Nakatani Y, et al. Primary signet-ring cell carcinoma of the lung: histochemical and immunohistochemical characterization. Hum Pathol 1999;30:378-383.
4. Merchant SH, Amin MB, Tamboli P, et al. Primary signet-ring cell carcinoma of the lung: immunohistochemical study and comparison with non-pulmonary signet-ring cell carcinomas. Am J Surg Pathol 2001;25: 1515-1519.
5. Hiraki A, Ueoka H, Yoshino T, et al. Primary signetring cell carcinoma of the lung with histochemical characterization. Anticancer Res 2002;22:1079-1081.
6. Tsuta K, Ishii G, Nitadori J, et al. Comparison of the immunophenotypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous bronchioloalveolar carcinoma of the lung characterized by the presence of cytoplasmic mucin. J Pathol 2006;209:78-87.
7. Wong PC, Ferenczy A, Fan LD, et al. Krukenberg tumors of the ovary. Ultrastructural, histochemical and immunohistochemical studies of 15 cases. Cancer 1986;57:751-760.
8. Chu PG, Weiss LM. Immunohistochemical characterization of signet-ring cell carcinomas of the stomach, breast, and colon. Am J Clin Pathol 2004;121:884-892.
9. Tung SY, Wu CS, Chen PC. Primary signet ring cell carcinoma of colorectum: an age-and sex-matched controlled study. Am J Gastroenterol 1996;91:2195-2199.
10. Goldstein NS, Long A, Kuan SF, et al. Colon signet ring cell adenocarcinoma: immunohistochemical characterization and comparison with gastric and typical colon adenocarcinomas. Appl Immunohistochem Mol Morphol 2000;8:183-188.
11. Frost AR, Terahata S, Yeh IT, et al. The significance of signet ring cells in infiltrating lobular carcinoma of the breast. Arch Pathol Lab Med 1995;119:64-68.
12. Liu SM, Chen DR. Signet-ring cell carcinoma of the breast. Pathol Int 2000;50:67-70.
13. Braun EV, Ali M, Fayemi AO, et al. Primary signet-ring cell carcinoma of the urinary bladder: review of the literature and report of a case. Cancer 1981;47: 1430-1435.
14. Kondo A, Ogisu B, Mitsuya H. Signet-ring cell carcinoma involving the urinary bladder. Report of a case and review of 21 cases. Urol Int 1981;36:373-379.
15. Kitamura H, Sumikawa T, Fukuoka H, et al. Primary signet-ring cell carcinoma of the urinary bladder. Report of two cases with histochemical studies. Acta Pathol Jpn 1985;35:675-686.
16. Bernstein SA, Reuter VE, Carroll PR, et al. Primary signet-ring cell carcinoma of urinary bladder. Urology 1988;31:432-436.
17. Bodi I, Andrews TC, Howard RS, et al. Carcinomatous meningitis from primary signet ring cell carcinoma of bladder. Histopathology 2004;44:394-396.
18. Marcy M, Chetaille B, Charafe-Jauffret E, et al. [Signet ring cell carcinoma of the pancreas: a case report]. Ann Pathol 2002;22:314-316; French.
19. Ghannoum JE, Freedman PD. Signet-ring cell (mucinproducing) adenocarcinomas of minor salivary glands. Am J Surg Pathol 2004;28:89-93.
20. Ro JY, El-Naggar A, Ayala AG, et al. Signet-ring-cell carcinoma of the prostate: electron-microscopic and immunohistochemical studies of eight cases. Am J Surg Pathol 1988;12:453-460.
21. Hejka AG, England DM. Signet ring cell carcinoma of prostate. Immunohistochemical and ultrastructural study of a case. Urology 1989;34:155-158.
22. Uchijima Y, Ito H, Takahashi M, et al. Prostate mucinous adenocarcinoma with signet ring cell. Urology 1990;36:267-268.
23. Alline KM, Cohen MB. Signet-ring cell carcinoma of the prostate. Arch Pathol Lab Med 1992;116: 99-102.
24. Smith C, Feddersen RM, Dressler L, et al. Signet ring cell adenocarcinoma of prostate. Urology 1994;43: 397-400.
25. Leong FJ, Leong AS, Swift J. Signet-ring carcinoma of the prostate. Pathol Res Pract 1996;192:1232-1238.
26. Randolph TL, Amin MB, Ro JY, et al. Histologic variants of adenocarcinoma and other carcinomas of prostate: pathologic criteria and clinical significance. Mod Pathol 1997;10:612-629.
27. Kuroda N, Yamasaki I, Nakayama H, et al. Prostatic signet-ring cell carcinoma: case report and literature review. Pathol Int 1999;49:457-461.
28. Fujita K, Sugao H, Gotoh T, et al. Primary signet ring cell carcinoma of the prostate: report and review of 42 cases. Int J Urol 2004;11:178-181.
29. MacDougall DB, Wang SE, Zidar BL. Mucin-positive epithelial mesothelioma. Arch Pathol Lab Med 1992;116:874-880.
30. Hammar SP, Bockus DE, Remington FL, et al. Mucinpositive epithelial mesotheliomas: a histochemical, immunohistochemical, and ultrastructural comparison with mucin-producing pulmonary adenocarcinomas. Ultrastruct Pathol 1996;20:293-325.
31. Cook DS, Attanoos RL, Jalloh SS, et al. 'Mucinpositive' epithelial mesothelioma of the peritoneum: an unusual diagnostic pitfall. Histopathology 2000;37: 33-36.
32. Guru PK, Phillips S, Ball MM, et al. Pseudomesotheliomatous presentation of primary signet ring cell carcinoma of lung. Indian J Chest Dis Allied Sci 2005;47:209-211.
33. Churg A, Roggli V, Galateau-Salle F, et al. Mesothelioma, In: Travis WD, Brambilla E, Mü ller-Hermelink HK, Harris CC (eds) WHO Classification of Tumours. Pathology & Genetics. Tumours of the Lung, Pleura, Thymus and Heart. IARC Press: Lyon, France; 2004, pp 128-136.
34. Allen TC. Recognition of histopathologic patterns of diffuse malignant mesothelioma in differential diagnosis of pleural biopsies. Arch Pathol Lab Med 2005;129:1415-1420.
35. Rekhi B, Pathuthara S, Ajit D, et al. 'Signet-ring' cells-a caveat in the diagnosis of a diffuse peritoneal mesothelioma occurring in a lady presenting with recurrent ascites: an unusual case report. Diagn Cytopathol 2010;38:435-439.
36. Nascimento AG, Keeney GL, Fletcher CD. Deciduoid peritoneal mesothelioma. An unusual phenotype affecting young females. Am J Surg Pathol 1994;18: 439-445.
37. Ordóñ ez NG. Epithelial mesothelioma with deciduoid features: report of four cases. Am J Surg Pathol 2000; 24:816-823.
38. Ordóñ ez NG. Deciduoid mesothelioma: report of 21 cases with review of the literature. Mod Pathol 2012; [Epub ahead of print].
39. Ordóñ ez NG, Myhre M, Mackay B. Clear cell mesothelioma. Ultrastruct Pathol 1996;20:331-336.
40. Ordóñ ez NG. Mesothelioma with clear cell features: an ultrastructural and immunohistochemical study of 20 cases. Hum Pathol 2005;36:465-473.
41. Kadota K, Suzuki K, Sima CS, et al. Pleomorphic epithelioid diffuse malignant pleural mesothelioma: a clinicopathological review and conceptual proposal to reclassify as biphasic or sarcomatoid mesothelioma J Thorac Oncol 2011;6:896-904.
42. Ordóñ ez NG. Pleomorphic mesothelioma: report of 10 cases. Mod Pathol 2012;25:1011-1022.
43. Mayall FG, Gibbs AR. The histology and immunohistochemistry of small cell mesothelioma. Histopathology 1992;20:47-51.
44. Ordóñ ez NG. Mesotheliomas with small cell features: report of eight cases. Mod Pathol 2012;25: 689-698.
45. Ordóñ ez NG. Mesothelioma with rhabdoid features: an ultrastructural and immunohistochemical study of 10 cases. Mod Pathol 2006;19:373-383.
46. Mart́nez-Consuegra N, Muñ oz-Juárez M, Ortiz-Hidalgo C. Unusual multifocal glomeruloid pattern in a well-differentiated papillary mesothelioma of the peritoneum. Int J Surg Pathol 2008;16:426-427.
47. Ordóñ ez NG. Mesotheliomas with crystalloid structures: report of nine cases, including one with oncocytic features. Mod Pathol 2012;25:272-281.
48. Shimazaki H, Aida S, Iizuka Y, et al. Vacuolated cell mesothelioma of the pericardium resembling liposarcoma: a case report. Hum Pathol 2000;31:767-770.
49. Kobayashi S, Ida M, Matsui O, et al. Lipomatous change in a brain metastasis from malignant pleural mesothelioma. Neuroradiology 2001;43:159-161.
50. Ordóñ ez NG. Value of thyroid transcription factor-1 immunostaining in tumor diagnosis: a review and update. Appl Immunohistochem Mol Morphol 2012; 20:429-444.
51. Ordóñ ez NG. Napsin A expression in lung and kidney neoplasia: a review and update. Adv Anat Pathol 2012;19:66-73.
52. Ordóñ ez NG. Value of thyroid transcription factor-1, E-cadherin, BG8, WT1, and CD44S immunostaining in distinguishing epithelial pleural mesothelioma from pulmonary and nonpulmonary adenocarcinoma. Am J Surg Pathol 2000;24:598-606.
53. Amatya VJ, Takeshima Y, Kohno H, et al. Caveolin-1 is a novel immunohistochemical marker to differentiate epithelioid mesothelioma from lung adenocarcinoma. Histopathology 2009;55:10-19.
54. Bishop JA, Sharma R, Illei PB. Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. Hum Pathol 2010;41:20-25.
55. Castro CY, Moran CA, Flieder DG, et al. Primary signet ring cell adenocarcinomas of the lung: a clinicopathological study of 15 cases. Histopathology 2001;39: 397-401.
56. Rossi G, Murer B, Cavazza A, et al. Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression. Am J Surg Pathol 2004;28:442-452.
57. Sentani K, Oue N, Tashiro T, et al. Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma. Am J Surg Pathol 2008;32:1182-1189.
58. Hirano T, Gong Y, Yoshida K, et al. Usefulness of TA02 (napsin A) to distinguish primary lung adenocarcinoma from metastatic lung adenocarcinoma. Lung Cancer 2003;41:155-162.
59. Inamura K, Satoh Y, Okumura S, et al. Pulmonary adenocarcinomas with enteric differentiation: histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas. Am J Surg Pathol 2005;29:660-665.
60. Terry J, Leung S, Laskin J, et al. Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples. Am J Surg Pathol 2010;34:1805-1811.
61. De Lott LB, Morrison C, Suster S, et al. CDX2 is a useful marker of intestinal-type differentiation: a tissue microarray-based study of 629 tumors from various sites. Arch Pathol Lab Med 2005;129: 1100-1105.
62. Tian MM, Zhao AL, Li ZW, et al. Phenotypic classification of gastric signet ring cell carcinoma and its relationship with clinicopathologic parameters and prognosis. World J Gastroenterol 2007;13:3189-3198.
63. Fadare O. Pleomorphic lobular carcinoma in situ of the breast composed almost entirely of signet ring cells. Pathol Int 2006;56:683-687.
64. Jones GE, Strauss DC, Forshaw MJ, et al. Breast cancer metastasis to the stomach may mimic primary gastric cancer: report of two cases and review of literature. World J Surg Oncol 2007;5:75.
65. Ordóñ ez NG. Application of immunohistochemistry in the diagnosis of epithelioid mesothelioma: a review and update. Hum Pathol; advance online publication September 2012 (e-pub ahead of print).
66. Hristova EN, Krishnamurthy S, Ro JY, et al. Pulmonary epithelioid hemangioendothelioma with prominent signet ring cell features mimicking metastatic adenocarcinoma. Ann Diagn Pathol 2003;7:160-164.
67. Sheibani K, Battifora H. Signet-ring cell melanoma. A rare morphologic variant of malignant melanoma. Am J Surg Pathol 1988;12:28-34.
68. LiVolsi VA, Brooks JJ, Soslow R, et al. Signet cell melanocytic lesions. Mod Pathol 1992;5:515-520.
69. Grilliot MA, Goldblum JR, Liu X. Signet-ring cell melanoma of the gastroesophageal junction: a case report and literature review. Arch Pathol Lab Med 2012;136:324-328.