Histologic variants of adenocarcinoma and other carcinomas of prostate: Pathologic criteria and clinical significance

Modern Pathology

Volumn 10, Issue 6, 1997, Pages 612-629

  Randolph, Todd L ^a   Amin, Mahul B ^a   Ro, Jae Y ^b   Ayala, Alberto G ^b  

^a HENRY FORD HOSPITAL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Adenocarcinoma; Mucinous carcinoma; Prostate; Prostatic duct adenocarcinoma; Sarcomatoid carcinoma; Signet ring cell carcinoma; Small cell carcinoma; Transitional cell carcinoma

Indexed keywords

ACINAR CELL; ADENOCARCINOMA; ANIMAL CELL; CANCER SURVIVAL; HISTOLOGY; HUMAN; MALE; NEEDLE BIOPSY; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE CARCINOMA; REVIEW; SIGNET RING CARCINOMA; SMALL CELL CARCINOMA; SURVIVAL RATE; TRANSITIONAL CELL CARCINOMA;

ADENOCARCINOMA; ADENOCARCINOMA, MUCINOUS; CARCINOMA; CARCINOMA, ENDOMETRIOID; CARCINOMA, SIGNET RING CELL; CARCINOMA, SMALL CELL; CARCINOSARCOMA; HUMANS; MALE; PROSTATIC NEOPLASMS;

EID: 0030795583     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (134)

1. Parker SL, Tong T, Bolden S, Wingo PA. Cancer statistics 1996. CA Cancer J Clin 1996;46:5-28.
2. Tetu B, Ro JY, Avala AG, Johnson DE, Logothetis CJ, Ordóñez NG. Small cell carcinoma of the prostate. Part I: a clinicopathologic study of 20 cases. Cancer 1987;59:1803-9.
3. Schron DS, Gipson T, Mendelsohn G. The histogenesis of small cell carcinoma of the prostate: an immunohistochemical study. Cancer 1984;53:2498-80.
4. Sarma DP, Weilbaecher TG. Small-cell carcinoma of prostate. Urology 1989;33:332-5.
5. Hagood PG, Johnson FE, Bedrossian CW, Silverberg AB. Small cell carcinoma of the prostate. Cancer 1991;67:1046-50.
6. Amato RJ, Logothetis CJ, Hallinan R, Ro JY, Sella A, Dexeus FH. Chemotherapy for small cell carcinoma of prostatic origin. J Urol 1992;147:935-7.
7. Oesterling JE, Hauzeur CG, Farrow GM. Small cell anaplastic carcinoma of the prostate: a clinical, pathological and immunohistological study of 27 patients. J Urol 1992;147: 804-7.
8. Bolton DM, Chiu ST, Clarke S, Angus D. Primary small cell carcinoma of the prostate: unusual modes of presentation. Aust N Z Surg 1994;64:91-4.
9. Moore SR, Reinberg Y, Zhang G. Small cell carcinoma of prostate: effectiveness of hormonal versus chemotherapy. Urology 1992;39:411-6.
10. Christopher ME, Seftel AD, Sorenson K, Resnick MI. Small cell carcinoma of the genitourinary tract: an immunohistochemical, electron microscopic and clinicopathological study. J Urol 1991;145:382-8.
11. Ro JY, Tetu B, Ayala AG, Ordóñez NG. Small cell carcinoma of the prostate. Part II: immunohistochemical and electron microscopic study of 18 cases. Cancer 1987;59:977-82.
12. DiSant' Agnese PA, de Mesy Jensen KL. Endocrine-paracrine cells of the prostate and prostatic urethra: an ultrastructural study. Hum Pathol 1984;15:1034-41.
13. Abrahamsson PA, Wadstrom LB, Alumets J, Falkmer S, Grimelius L. Peptide-hormone- and serotinin-immunore-active tumour cells in carcinoma of the prostate. Pathol Res Pract 1987;182:298-307.
14. Adlakha KH, Bostwick DG. Paneth cell-like change in prostatic adenocarcinoma represents neuroendocrine differentiation: report of 30 cases. Hum Pathol 1994;25:135-9.
15. Smith DC, Tucker JA, Trump DL. Hypercalcemia and neuroendocrine carcinoma of the prostate: a report of three cases and a review of the literature. J Clin Oncol 1992;10: 499-505.
16. Tetu B, Ro JY, Avala AG, Ordóñez NG, Logothetis CJ, von-Eschenbach AC. Small cell carcinoma of prostate associated with myasthenic (Eaton-Lambert) syndrome. Urology 1989;33:148-52.
17. Wenk RE, Bhagavan BS, Levy R, Miller D, Weisburger W. Ectopic ACTH, prostatic oat cell carcinoma and marked hypernatremia. Cancer 1977;40:733-78.
18. Ghali VS, Garcia RL. Prostatic adenocarcinoma with carcinoidal features producing adrenocorticotropic syndrome: immunohistochemical study and review of the literature. Cancer 1984;40:773-8.
19. Hindson DA, Knight LL, Ocker JM. Small cell cancer of prostate: transient complete remission with chemotherapy. Urology 1985;26:182-4.
20. Melicow MM, Pachter MR. Endometrial carcinoma of prostate utricle (uterus masculinus). Cancer 1967;20:1715-22.
21. Amin MB, Ro JY, Ayala AG. Clinical relevance of histologic variants of prostate cancer. Cancer Bull 1993;45:403-10.
22. Ro J, Ayala A, Wishnow K, Ordóñez N. Prostatic duct adenocarcinoma with endometrioid features: immunohistochemical and electron microscopic study. Semin Diagn Pathol 1988;5:301-11.
23. Dube VE, Farrow GM, Greene LF. Prostatic adenocarcinoma of ductal origin. Cancer 1973;32:402-9.
24. McNeal J, Yemoto C. Spread of adenocarcinoma within prostatic ducts and acini: morphologic and clinical correlations. Am J Surg Pathol 1996;20:802-14.
25. Amin MB, Schultz DS, Zarbo RJ. Analysis of cribriform morphology in prostate neoplasia using antibody to high molecular weight cytokeratins [abstract]. Mod Pathol 1992; 5:50A.
26. McNeal J, Reese J, Redwine E, Frieha F, Stamey T. Cribiform adenocarcinoma of prostate. Cancer 1986;58:1714-9.
27. Zaloudek C, Williams JW, Kempson RL. "Endometrial" adenocarcinoma of the prostate: a distinctive tumor of prostatic duct origin. Cancer 1976;37:2255-62.
28. Bostwick DG, Kindrachuk RW, Rouse RV. Prostatic adenocarcinoma with endometrioid features: clinical, pathologic, and ultrastructural findings. Am J Surg Pathol 1985;9:595-609.
29. Christensen WN, Steinberg C, Walsh PC, Epstein JI. Prostatic duct adenocarcinoma: findings at radical prostatectomy. Cancer 1991;67:2118-24.
30. Gilbert RF, Ibarra J, Tansey LA, Shamberg AM. Adenocarcinoma in a Mullerian duct cyst. J Urol 1992;148:1262-4.
31. Sufrin G, Gaeta J, Staubitz WJ, Ajrawat HS, Murphy GP. Endometrial carcinoma of prostate. Urology 1986;27:18-23.
32. Melicow MM, Tannenbaum M. Endometrial carcinoma of uterus masculinus (prostatic utricle): report of 6 cases. J Urol 1971;106:892-902.
33. Young BW, Lagios MD. Endometrial (papillary) carcinoma of the prostatic utricle: response to orchiectomy: a case report. Cancer 1973;32:1293-1300.
34. Rotterdam HZ, Melicow MM. Double primary prostatic adenocarcinoma. Urology 1975;6:245-8.
35. Aydin F. Endometrioid adenocarcinoma of prostatic urethra presenting with anterior urethral implantation. Urology 1993;41:91-5.
36. Epstein JI, Woodruff JM. Adenocarcinoma of the prostate with endometrioid features: a light microscopic and immunohistochemical study of 10 cases. Cancer 1986;57:111-9.
37. Shannon RI, Ro JY, Grignon DJ, Ordóñez NG, Johnson DE, Mackay B, et al. Sarcomatoid carcinoma of the prostate: a clinicopathologic study of 12 cases. Cancer 1992;69:2676-82.
38. Ogawa K, Kim YC, Nakashima Y. Expression of epithelial markers in sarcomatoid carcinoma: an immunohistochemical study. Histopathology 1987;11:511-22.
39. Lauwers GY, Schevchuk M, Armenakas N, Reuter VE. Carcinosarcoma of the prostate. Am J Surg Pathol 1993;17: 342-9.
40. Nazeer T, Barada JH, Fisher HA, Ross JS. Prostatic carcinosarcoma: case report and review of literature. J Urol 1991; 146:1370-3.
41. Lindboe CF, Mjones J: Carcinonsarcoma of prostate. Immunohistochemical and ultrastructural observations. Urology 1992;40:376-80.
42. Kubosawa H, Matsuzaki O, Kondo Y, Takao M, Sato N. Carcinosarcoma of the prostate. Acta Pathol Japonica, 1993;43:209-14.
43. Kaneko Y, Yoshiki T, Fukumoto M, Oishi K, Yoshida O. Carcinosarcoma of the prostate. Urol Int 1992;48:105-7.
44. Algaba F, Sole-Balcells FJ. Carcinocarcomas of the prostate. Immunophenotype, morphologic course, and clinicopathologic differential diagnosis. Archiv Espanol Urol 1992;45: 779-82.
45. Dundore PA, Cheville JC, Nascimento AG, Farrow GM, Bostwick DG. Carcinosarcoma of prostate: report of 21 cases. Cancer 1995;76:1035-42.
46. Sahin AS, Ro JY, El-Naggar AK, Ordóñez NG, Babaian RJ, Ayala AG. Pseudosarcomatous fibromyxoid tumor of prostate. Am J Clin Pathol 1991;96:253-8.
47. Proppe KH, Scully RE, Rosai J. Post operative spindle cell nodules of the genitourinary tract resembling sarcomas. Am J Surg Pathol 1984;8:101-8.
48. Huang WL, Ro JY, Grignon DJ, Swanson D, Ordóñez NG. Postoperative spindle cell nodule of the prostate and bladder. J Urol 1990;143:824-6.
49. Ro JY, El-Naggar A, Amin MB, Sahin AA, Ordóñez NG. Pseudosarcomatous fibromyxoid tumor of the bladder and prostate: immunohistochemical, ultrastructural, and DNA flow cytometric analysis of nine cases. Hum Pathol 1993; 24:1203-10.
50. Attah E, Powell M. Atypical stromal hyperplasia of the prostate gland. Am J Clin Pathol 1977;67:324-7.
51. Leong S, Vogt P, Yu G. Atypical stromal smooth muscle hyperplasia of prostate. Urology 1988;31:163-7.
52. Attah E, Nkposong E. Phyllodes type of atypical prostatic hyperplasia. J Urol 1976;115:762-4.
53. Reese J, Lombard C, Krone K, Stamey TA. Phyllodes type of atypical prostatic hyperplasia: a report of three new cases. J Urol 1987;115:623-6.
54. Ito H, Ito M, Mitsuhata N, Tahara E. Phyllodes tumor of the prostate: a case report. Jpn J Clin Oncol 1989;19:299-304.
55. Manivel C, Shenoy B, Wick M, Dehner LP. Cystosarcoma phyllodes of the prostate. Arch Pathol Lab Med 1986;110: 534-8.
56. Lopez-Beltran A, Gaeta J, Huben R, Croghan GA. Malignant phyllodes tumor of prostate. Urology 1990;35:164-7.
57. Gueft B, Walsh M. Malignant prostatic cystosarcoma phyllodes. N Y State J Med 1975;75:2226-8.
58. Yokota T, Yamashita Y, Okuzono Y, et al. Malignant cystosarcoma phyllodes of prostate. Acta Pathol Jpn 1984;34: 663-8.
59. 58a. Boyd S. A case of colloid scirrhus of the prostate. Trans Pathol Soc Lond 1882;33:200-3.
60. Epstein JI. Lieberman PH. Mucinous adenocarcinoma of the prostate gland. Am J Surg Pathol 1985;9:299-308.
61. Ro JY, Grignon DJ, Ayala AG, Fernandez PL, Ordóñez NG, Wishnow KI. Mucinous adenocarcinoma of the prostate: histochemical and immunohistochemical studies. Hum Pathol 1990;21:593-600.
62. Bostwick DG. Neoplasms of the prostate. In: Bostwick DG, Eble JN, editors. Urologic surgical pathology. St Louis: Mosby, 1997:343-421.
63. Alfthan O, Koivuniemi A. Mutinous carcinoma of the prostate: case report. Scand J Urol Nephrol 1977;4:78-80.
64. Proia AD, McCarty KS, VVoodard BH. Prostatic mucinous adenocarcinoma: a Cowper gland carcinoma mimicker. Am J Surg Pathol 1981;5:701-6.
65. Odom DG, Donatucci CF, Deshon GE. Mucinous adenocarcinoma of the prostate. Hum Pathol 1986;17:863-5.
66. Manne RK, Haddad FS. Mucinous adenocarcinoma of prostate. Urology 1989;33:247-9.
67. Elbadawi A, Craig W, Linke CA, Cooper RA Jr. Prostate mucinous carcinoma. Urology 1979;13:658-66.
68. Cricco RP, Kassis J. Mucinous adenocarcinoma of prostate. Urology 1979;14:276-8.
69. Sika JV, Buckley JJ. Mucus-forming adenocarcinoma of prostate. J Urol 1977;118:124-5.
70. Chica G, Johnson DE, Ayala AG. Mucinous adenocarcinoma of the prostate. J Urol 1977;118:124-5.
71. Lightbourn GA, Abrams M, Seymour L. Primary mucoid adenocarcinoma of the prostate gland with bladder invasion. J Urol 1969;101:78-80.
72. Lee DW, Ro JY, Sahin AA, Lee JS, Ayala AG. Mucinous adenocarcinoma of the prostate with endobronchial metastasis. Am J Clin Pathol 1990;94:641-6.
73. Teichman JMH, Shabaik A, Demby AM. Mucinous adenocarcinoma of the prostate and hormone sensitivity. J Urol 1994;151:701-2.
74. McNeal JE, Alroy J, Villers A, Redwine EA, Stamey TA. Mucinous differentiation in prostatic adenocarcinoma. Hum Pathol 1991;22:979-88.
75. Outwater E, Schrieber ML, Tomaszewski JE, Schnall MD. Mucinous carcinomas involving the prostate: atypical findings at MR imaging. J Magn Reson Imaging 1992;2:597-600.
76. Ro JY, El-Naggar A, Ayala AG. Signet-ring-cell carcinoma of the prostate: electron-microscopic and immunohistochemical studies of eight cases. Am J Surg Pathol 1988;12: 453-60.
77. Giltman LI. Signet-ring adenocarcinoma of the prostate. J Urol 1981;126:134-5.
78. Remmele W, Weber A, Harding P. Primary signet ring cell carcinoma of the prostate. Hum Pathol 1988;19:478-80.
79. Alline KM, Cohen MB. Signet-ring cell carcinoma of the prostate. Arch Pathol Lab Med 1992;116:99-102.
80. Uchijima Y, Ito H, Takahashi M, Yamashina M. Prostate mucinous adenocarcinoma with signet ring cells. Urology 1990;36:267-8.
81. Hejka A, England D. Signet ring cell carcinoma of prostate: immunohistochemical and ultrastructural study of a case. Urology 1989;34:155-8.
82. Smith C, Feddersen RM, Dressler L, McConnell T, Milroy M, Smith AY. Signet ring cell adenocarcinoma of prostate. Urology 1994;43:397-400.
83. Skordras G, Wang J, Kragel PJ. Primary prostatic signet-ring cell carcinoma. Urology 1993;42:338-42.
84. Catton PA, Hartwick RWJ, Srigley JR. Prostate cancer presenting with malignant ascites: signet-ring cell variant of prostatic adenocarcinoma. Urology 1992;39:495-7.
85. Alguacil-Garcia A. Artifactual changes mimicking signet-ring-cell carcinoma of transurethral prostatectomy specimens. Am J Surg Pathol 1986;41:795-800.
86. Schned A. Artifactual signet-ring cells [letter]. Am J Surg Pathol 1987;10:795-800.
87. Bostwick DG, Adalkha K. Lymphoepithelioma-like carcinoma of the prostate. J Urol Pathol 1994;2:319-25.
88. Amin MB, Ro JY, Lee KM, Ordóñez NG, Ayala AG. Lymphoepithelioma-like carcinoma of the urinary bladder. Am J Surg Path 1994;18:466-73.
89. Accetta PA, Gardner WA. Squamous metastases from prostatic adenocarcinoma [abstract]. Lab Invest 1982;46:2.
90. Moyana TN. Adenosquamous carcinoma of the prostate. Am J Surg Pathol 1987;11:403-7.
91. Saito R, Davis BK, Ollapally EP. Adenosquamous carcinoma of the prostate. Hum Pathol 1984;15:87-9.
92. Lager DJ, Goeken JA, Kemp JD, Robinson RA. Squamous metaplasia of the prostate: an immunohistochemical study. Am J Clin Pathol 1988;90:597-601.
93. Bennett RS, Edgerton EO. Mixed prostatic carcinoma. J Urol 1973;110:561-3.
94. Gray GF, Marshall VF. Squamous carcinoma of the prostate. J Urol 1975;113:736-8.
95. Sieracki JC. Epidermoid carcinoma of the human prostate: report of three cases. Lab Invest 1955;4:232-40.
96. Arnheim FK. Carcinoma of the prostate: a study of post-mortem finding in 176 cases. J Urol 1948;60:599-603.
97. Kahler JE. Carcinoma of the prostate gland: a pathologic study. J Urol 1939;41:557-74.
98. Thompson GI. Transurethral resection of malignant lesions of the prostate gland. JAMA 1942;120:1105-9.
99. Mostofi FK, Price EB Jr. Tumors of the male genital system. In: Firminger HI, editor. Atlas of tumor pathology. Series 2. Fasc. 8. Washington, DC: Armed Forces Institute of Pathology, 1973:177-258.
100. Sarma DP, Weilbaecher TG, Moon TD. Squamous cell carcinoma of prostate. Urology 1991;37:260-2.
101. Wernert N, Goebbels R, Bonkhoff H, Dhom G. Squamous cell carcinoma of the prostate. Histopathology 1990;17:339-44.
102. Mott LJM. Squamous cell carcinoma of the prostate: report of two cases and review of the literature. J Urol 1979;121: 833-5.
103. Braslis K, Davi R, Nelson E, Civantos F, Soloway M. Squamous cell carcinoma of the prostate: a transformation from adenocarcinoma after the use of a luteinizing hormone-releasing hormone antagonist and flutamide. Urology 1995; 45:329-31.
104. Devaney DM, Dorman A, Leader M. Adenosquamous carcinoma of the prostate: a case report. Hum Pathol 1991;22: 1046-50.
105. Al Adrani MS. Schistosomiasis, metaplasia, and squamous cell carcinoma of the prostate: histogenesis of the squamous cells determined by localization of specific marker. Neoplasia 1985;32:613-22.
106. Gattuso P, Carson HJ, Candel A, Castelli MJ. Adenosquamous carcinoma of the prostate. Hum Pathol 1995;26:123-6.
107. Little NA, Wiener JS, Walther PJ, Paulson DF, Anderson EE. Squamous cell carcinoma of the prostate: two cases of a rare malignancy and review of the literature. J Urol 1993; 149:137-9.
108. Corder MP, Cicmil GA. Effective treatment of metastatic squamous cell carcinoma of the prostate with adriamycin. J Urol 1976;115:222.
109. Thompson GJ, Albers DD, Broders AC. Unusual carcinomas involving the prostate gland. J Urol 1953;69:416-25.
110. Denholm SW, Webb JN, Howard GCW, Chisholm GD. Basaloid carcinoma of the prostate gland: histogenesis and review of the literature. Histopathology 1992;20:151-5.
111. Devraj LJ, Bostwick DG. Atypical basal cell hyperplasia of the prostate. Immunophenotypic profile and proposed classification of basal cell proliferation. Am J Surg Pathol 1993;17:645-59.
112. Young RH, Frierson HF Jr, Mills SE, Kaiser JS, Talbot WH, Bhan AK. Adenoid cystic-like tumor of the prostate gland: a report of two cases and review of the literature on "adenoid cystic carcinoma" of the prostate. Am J Clin Pathol 1988; 89:49-56.
113. Gleason DF. Atypical hyperplasia, and well-differentiated adenocarcinoma of the prostate. Am J Surg Pathol 1985;9: 53-67.
114. Mostofi FK, Sesterhenn I, Sobin LH. Histological typing of prostate tumors. In: International histologic classification of tumors. Geneva: World Health Organization, 1980.
115. Epstein JI, Armas OA. Atypical basal cell hyperplasia of the prostate. Am J Surg Pathol 1992;16:1205-14.
116. Cohen RJ, Goldberg RD, Verhaart MJS, Cohen M. Adenoid cyst-like carcinoma of the prostate gland. Arch Pathol Lab Med 1993;117:799-801.
117. Grignon DJ, Ro JV, Ordóñez NG, Ayala AG, Cleary KR. Basal cell hyperplasia, adenoid basal cell tumor, and adenoid cystic carcinoma of the prostate gland: an immunohistochemical study. Hum Pathol 1988;19:1425-33.
118. Reed RJ. Consultation case. Am J Surg Pathol 1984;18:699-704.
119. Goebbels R, Amberger L, VVernert N, Dhom G. Urothelial carcinoma of the prostate. Appl Pathol 1985;3:242-54.
120. Ordóñez NG, Ro JY, Ayala AG. Application of immunocytochemistry of the prostate. In: Bostwick DG, editor. Pathology of the prostate, Churchill Livingstone, New York: 1990: 137-60.
121. Greene LF, O'Dea MJ, Dockerty MB. Primary transitional cell carcinoma of the prostate. J Urol 1976;116:761-3.
122. Rubinstein AB, Rubnitz ME. Transitional cell carcinoma of the prostate. Cancer 1969;24:543-6.
123. Wendelken JR, Schellhammer PF, Ladaga LE, El-Mahdi AM. Transitional cell carcinoma: cause of refactory cancer of the prostate. Urology 1979;13:557-60.
124. Ro JY, Ayala AG, El-Naggar A, Wishnow KI. Seminal vesicle involvement by in situ and invasive transitional cell carcinoma of the bladder. Am J Surg Path 1987;11:951-8.
125. Wishnow KI, Ro JY. Importance of early treatment of transitional cell carcinoma of prostatic ducts. Urology 1988;32:11-2.
126. Terris MK, Villers A, Freiha FS. Transrectal ultrasound appearance of transitional cell carcinoma involving the prostate. J Urol 1990;143:953-6.
127. Wood DP, Montie JE, Pontesje FS, VanderBrug-Medendorp S, Levin HS. Transitional cell carcinoma of the prostate in cystoprostatectomy specimens removed for bladder cancer. J Urol 1989;141:346-9.
128. Mahadevia PS, Koss LG, Tar IJ. Prostatic involvement in bladder cancer: prostate mapping in 20 cystoprostatectomy specimens. Cancer 1986;58:2095-102.
129. Schellhammer PF, Bean MA, Whitmore WF Jr. Prostatic involvement by transitional cell carcinoma: pathogenesis, patterns and prognosis. J Urol 1977;118:399-403.
130. Reese JH, Freiha FS, Gelb AB, Lum BL, Torti FM. Transitional-cell carcinoma of the prostate in patients undergoing radical cystoprostatectomy. J Urol 1991;147:92-5.
131. Kablain JN, McNeaJ JE, Price HM, Frieha FS, Stamey TA. Unsuspected adenocarcinoma of prostate in patients undergoing cystoprostatectomy for other causes: incidence, histology and morphometric observations. J Urol 1989;141: 1091-4.
132. Montie JE, Wood DP, Pontes JE, Boyett JM, Levin HS. Adenocarcinoma of prostate in cystoprostatectomy specimens removed for bladder cancer. Cancer 1989;63:381-5.
133. Hillyard RW Jr, Ladaga L, Schellhammer PF. Superficial transitional cell carcinoma of the bladder associated with mucosal involvement of the prostatic urethra: results of treatment with intravesicle bacillus Calmette-Guérin. J Urol 1988;139:290-3.
134. Bretton PR, Herr HW, Whitmore WF, Badalament RA, Kimmel M, Provet J, et al. Intravesical bacillus Calmette-Guérin therapy for in situ transitional cell carcinoma involving the prostatic urethra. J Urol 1989;141:853-6.