Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1756-1763

  Keenan, Martine ^a   Alexander, Paul W ^a   Diao, Hugo ^a   Best, Wayne M ^a   Khong, Andrea ^b   Kerfoot, Maria ^b   Thompson, R C Andrew ^b   White, Karen L ^c   Shackleford, David M ^c   Ryan, Eileen ^c   Gregg, Alison D ^c   Charman, Susan A ^c   Von Geldern, Thomas W ^d   Scandale, Ivan ^d   Chatelain, Eric ^d  

^a Murdoch University Campus   (Australia)

^b MURDOCH UNIVERSITY   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d Drugs for Neglected Diseases Initiative DNDi   (Switzerland)

Author keywords

Chagas disease; Fenarimol; Inhibition; Trypanosoma cruzi

Indexed keywords

1 (BENZENESULFONYL) 4 [(4 CHLOROPHENYL)(PYRIDIN 3 YL)METHYL]PIPERAZINE; 1 [(4 CHLORO 2 FLUOROPHENYL)(PYRIDIN 3 YL)METHYL] 4 METHANESULFONYLPIPERAZINE; 1 [(4 CHLORO 2 FLUOROPHENYL)(PYRIDIN 3 YL)METHYL]PIPIPERAZINE; 1 [(4 CHLOROPHENYL)(PYRIDIN 3 YL)METHYL] 4 PHENYLPIPERAZINE; 1 [(4 CHLOROPHENYL)(PYRIDIN 3 YL)METHYL]PIPERAZINE; 1 [4 ((4 CHLOROPHENYL)(PYRIDIN 3 YL)METHYL)PIPERAZIN 1 YL]ETHAN 1 ONE; 1 [PHENYL(PYRIDIN 3 YL)METHYL]PIPERAZINYL DERIVATIVE; 3 [CHLORO(4 CHLORO 2 FLUOROPHENYL)METHYL]PYRIDINE; 3 [CHLORO(4 CHLOROPHENYL)METHYL]PYRIDINE; 4 [(4 CHLOROPHENYL)(PYRIDIN 3 YL)METHYL] N PHENYLPIPERAZINE 1 CARBOXAMIDE; AMIDE; ANTIPARASITIC AGENT; BENZAMIDE DERIVATIVE; BENZNIDAZOLE; CARBAMIC ACID DERIVATIVE; CARBONIC ACID DERIVATIVE; CITRIC ACID; FENARIMOL; PHENYL 4 [(4 CHLOROPHENYL)(PYRIDIN 3 YL)METHYL]PIPERAZINE 1 CARBOXYLATE; PIPERAZINE DERIVATIVE; POSACONAZOLE; SULFONAMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG HALF LIFE; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ADMINISTRATION, ORAL; ANIMALS; CHAGAS DISEASE; DRUG DESIGN; HUMANS; MICE; PIPERAZINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 84875219457     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.050     Document Type: Article

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