Possible association of nicotinic acetylcholine receptor gene (CHRNA4 and CHRNB2) polymorphisms with nicotine dependence in Japanese males: An exploratory study

Pharmacopsychiatry

Volumn 46, Issue 2, 2013, Pages 77-82

  Chen, H I ^a,b   Shinkai, T ^a   Utsunomiya, K ^a   Yamada, K ^a   Sakata, S ^a   Fukunaka, Y ^a   Hwang, R ^c   De Luca, V ^c   Ohmori, O ^a,d   Kennedy, J L ^c   Chuang, H Y ^b,e   Nakamura, J ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c UNIVERSITY OF TORONTO   (Canada)

^d Wakato Hospital   (Japan)

^e KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

association study; CHRNA4; CHRNB2; gene gene interaction; nicotine dependence; polymorphism

Indexed keywords

GENOMIC DNA; NICOTINIC RECEPTOR ALPHA4; NICOTINIC RECEPTOR BETA2;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DNA EXTRACTION; DOSE RESPONSE; ETHNICITY; EXPLORATORY RESEARCH; FAGERSTROM TEST FOR NICOTINE DEPENDENCE; GENE EXPRESSION; GENE FREQUENCY; GENE GENE INTERACTION; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC MODEL; GENOTYPE; HETEROZYGOTE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TOBACCO DEPENDENCE; WORKER;

ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; EPISTASIS, GENETIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, NICOTINIC; TOBACCO USE DISORDER;

EID: 84875219440     PISSN: 01763679     EISSN: 14390795     Source Type: Journal    
DOI: 10.1055/s-0032-1323678     Document Type: Article

References (36)

1. Jha P. Avoidable global cancer deaths and total deaths from smoking. Nat Rev Cancer: 2009; 9 655 664
2. Jorenby D. E., Hays J. T., Rigotti N. A. et al. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA: 2006; 296 56 63
3. Hogg R. C., Bertrand D. Neuroscience. What genes tell us about nicotine addiction. Science: 2004; 306 983 985 (Pubitemid 39482890)
4. Drago J., McColl C. D., Horne M. K. et al. Neuronal nicotinic receptors: insights gained from gene knockout and knockin mutant mice. Cell Mol Life Sci: 2003; 60 1267 1280 (Pubitemid 36900512)
5. Fowler C. D., Arends M. A., Kenny P. J. Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice. Behav Pharmacol: 2008; 19 461 484
6. Marubio L. M., Gardier A. M., Durier S. et al. Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors. Eur J Neurosci: 2003; 17 1329 1337 (Pubitemid 36560833)
7. Picciotto M. R., Zoli M., Rimondini R. et al. Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature: 1998; 391 173 177 (Pubitemid 28092475)
8. Lena C., Changeux J. P. The role of beta 2-subunit-containing nicotinic acetylcholine receptors in the brain explored with a mutant mouse. Ann N Y Acad Sci: 1999; 868 611 616 (Pubitemid 29281172)
9. Maskos U., Molles B. E., Pons S. et al. Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. Nature: 2005; 436 103 107 (Pubitemid 40966193)
10. Tapper A. R., McKinney S. L., Nashmi R. et al. Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science: 2004; 306 1029 1032 (Pubitemid 39482905)
11. Brody A. L., Mandelkern M. A., London E. D. et al. Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. Arch Gen Psychiatry: 2006; 63 907 915 (Pubitemid 44192334)
12. Wullner U., Gundisch D., Herzog H. et al. Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain. Neurosci Lett: 2008; 430 34 37
13. Hutchison K. E., Allen D. L., Filbey F. M. et al. CHRNA4 and tobacco dependence: from gene regulation to treatment outcome. Arch Gen Psychiatry: 2007; 64 1078 1086 (Pubitemid 47360853)
14. Winterer G., Musso F., Konrad A. et al. Association of attentional network function with exon 5 variations of the CHRNA4 gene. Hum Mol Genet: 2007; 16 2165 2174 (Pubitemid 47354899)
15. Chu C. J., Yang Y. C., Wei J. X. et al. Association of nicotinic acetylcholine receptor subunit alpha-4 polymorphisms with smoking behaviors in Chinese male smokers. Chin Med J (Engl): 2011; 124 1634 1638
16. Feng Y., Niu T., Xing H. et al. A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. Am J Hum Genet: 2004; 75 112 121 (Pubitemid 38801907)
17. Breitling L. P., Dahmen N., Mittelstrass K. et al. Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5 500 Germans. Pharmacogenomics J: 2009; 9 219 224
18. Ehringer M. A., Clegg H. V., Collins A. C. et al. Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. Am J Med Genet B Neuropsychiatr Genet: 2007; 144B 596 604 (Pubitemid 47077142)
19. Wessel J., McDonald S. M., Hinds D. A. et al. Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerstrom test for nicotine dependence. Neuropsychopharmacology: 2010; 35 2392 2402
20. Bierut L. J., Madden P. A., Breslau N. et al. Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet: 2007; 16 24 35 (Pubitemid 46152542)
21. Saccone N. L., Saccone S. F., Hinrichs A. L. et al. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet: 2009; 150B 453 466
22. Saccone S. F., Hinrichs A. L., Saccone N. L. et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Gene: 2007; 16 36 49 (Pubitemid 46152543)
23. Ehringer M. A., McQueen M. B., Hoft N. R. et al. Association of CHRN genes with "dizzinesso" to tobacco. Am J Med Genet B Neuropsychiatr Genet: 2010; 153B 600 609
24. Liu J. Z., Tozzi F., Waterworth D. M. et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet: 2010; 42 436 440
25. Han S., Gelernter J., Luo X. et al. Meta-analysis of 15 genome-wide linkage scans of smoking behavior. Biol Psychiatry: 2010; 67 12 19
26. Mineur Y. S., Picciotto M. R. Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction. Biochem Pharmacol: 2008; 75 323 333 (Pubitemid 350235388)
27. Heatherton T. F., Kozlowski L. T., Frecker R. C. et al. The Fagerstrom test for nicotine dependence: a revision of the Fagerstrom tolerance questionnaire. Br J Addict: 1991; 86 1119 1127
28. Ciulla T. A., Sklar R. M., Hauser S. L. A simple method for DNA purification from peripheral blood. Anal Biochem: 1988; 174 485 488
29. Rodriguez S., Gaunt T. R., Day I. N. Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol: 2009; 169 505 514
30. Purcell S., Cherny S. S., Sham P. C. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics: 2003; 19 149 150 (Pubitemid 36150192)
31. Barrett J. C., Fry B., Maller J. et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics: 2005; 21 263 265 (Pubitemid 40202029)
32. Dudbridge F. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered: 2008; 66 87 98 (Pubitemid 351482562)
33. Ramensky V., Bork P., Sunyaev S. Human non-synonymous SNPs: server and survey. Nucleic Acids Res: 2002; 30 3894 3900 (Pubitemid 35012462)
34. Wjst M. Target SNP selection in complex disease association studies. BMC bioinformatics: 2004; 5 92
35. Reumers J., Schymkowitz J., Ferkinghoff-Borg J. et al. SNPeffect: a database mapping molecular phenotypic effects of human non-synonymous coding SNPs. Nucleic Acids Res: 2005; 33 D527 D532 (Pubitemid 40207930)
36. Stevens V. L., Bierut L. J., Talbot J. T. et al. Nicotinic receptor gene variants influence susceptibility to heavy smoking. Cancer Epidemiol Biomarkers Prev: 2008; 17 3517 3525