Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: In vivo and in silico data suggest a hierarchical model

Journal of Clinical Pathology

Volumn 66, Issue 4, 2013, Pages 335-342

  Midgley, John E M ^a   Hoermann, Rudolf ^b   Larisch, Rolf ^b   Dietrich, Johannes W ^c  

^a North Lakes Clinical ^*  (United Kingdom)

^b Klinikum Luedenscheid   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

THYROTROPIN; THYROXINE;

ADULT; AGED; ARTICLE; COMPUTER MODEL; EUTHYROIDISM; FEEDBACK SYSTEM; FREE THYROXINE INDEX; HORMONE ACTION; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; IN VIVO STUDY; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MATHEMATICAL MODEL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SENSITIVITY ANALYSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AUTOANTIBODIES; AUTOANTIGENS; BIOLOGICAL MARKERS; COMPUTER SIMULATION; FEEDBACK, PHYSIOLOGICAL; HUMANS; HYPERTHYROIDISM; HYPOTHYROIDISM; IODIDE PEROXIDASE; IRON-BINDING PROTEINS; LINEAR MODELS; MIDDLE AGED; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS; NONLINEAR DYNAMICS; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; THYROID DISEASES; THYROID FUNCTION TESTS; THYROID GLAND; THYROTROPIN; THYROXINE; YOUNG ADULT;

EID: 84875216825     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2012-201213     Document Type: Article

References (46)

1. Larsen PR. Thyroid-pituitary interaction: Feedback regulation of thyrotropin secretion by thyroid hormones. N Engl J Med 1982;306:23-32.
2. Demers LM, Spencer CA. Thyrotropin/Thyroid Stimulating Hormone (TSH) measurement. Thyroid 2008;13:33-44.
3. Laurberg P, Andersen S, Carlé A, et al. The TSH upper reference limit: Where are we at? Nature Rev Endocrinol 2011;7:232-9.
4. Dietrich JW, Fischer M, Jauch J, et al. SPINA-THYR: A novel systems theoretic approach to determine the secretion capacity of the thyroid gland. Europ J Intern Med 1999;10(Suppl 1):S34.
5. Dietrich JW, TESCHE A, Pickardt CR, et al. Thyrotropic feedback control: Evidence for an additional ultrashort feedback loop from fractal analysis. Cybern Syst 2004;35:315-31.
6. Hoermann R, Eckl W, Hoermann C, et al. Complex relationship between free thyroxine and TSH in the regulation of thyroid function. Eur J Endocrinol 2010;162:1123-9.
7. Clark PM, Holder RL, Haque SM, et al. The relationship between serum TSH and free T4 in older people. J Clin Pathol 2012;65:463-5.
8. Dietrich JW. Der Hypophysen-Schilddrüsen-Regelkreis. Entwicklung und klinische Anwendung eines nichtlinearen Modells. Berlin: Logos-Verlag 2002;1-188.
9. Dietrich JW. SimThyr version 3.1: A simulation program for thyrotropic feedback control. 2012. http://sourceforge.net/projects/simthyr/(released 4 Jun 2012
10. Sobol I. Sensitivity analysis for non-linear mathematical models. Math Model Comput Exp 1993;1:407-14.
11. R Core Development Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing. 2011;ISBN 3-900051-07-0, http://www.R-project.org/(accessed 10 Dec 2011
12. Fellows I. Deducer: Deducer R package version 0.4-4. 2011. http://www.R-project.org/(accessed 10 Dec 2011
13. Friedman JH. Multivariate adaptive regression splines. Ann Stat 1991;19:1-67.
14. Milborrow S. 'EARTH': Multivariate Adaptive Regression Spline Models. Version 3.2.3. 2012. http://www.R-project.org/(accessed 2 Jun 2012
15. Andersen S, Pedersen KM, Bruun NH, et al. Narrow individual variations in serum T(4) and T(3) in normal subjects: A clue to the understanding of subclinical thyroid disease. J Clin Endocrinol Metab 2002;87:1068-72.
16. Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002;87:489-99.
17. Dickey RA, Wartofsky L, Feld S. Optimal thyrotropin level: Normal ranges and reference intervals are not equivalent. Thyroid 2005;15:1035-9.
18. Spencer CA, LoPresti JS, Patel A, et al. Applications of a new chemiluminometric thyrotropin assay to subnormal measurement. J Clin Endocrinol Metab 1990;70:453-60.
19. Leow MKS. A mathematical model of pituitary-thyroid interaction to provide an insight into the nature of the thyrotropin-thyroid hormone relationship. J Theoret Biol 2007;248:275-87.
20. Benhadi N, Fliers E, Visser TJ, et al. Pilot study on the assessment of the setpoint of the hypothalamus-pituitary-thyroid axis in healthy volunteers. Eur J Endocrinol 2010;162:323-9.
21. van Deventer HE, Mendu DR, Remaley AT, et al. Inverse log-linear relationship between thyroid-stimulating hormone and free thyroxine measured by direct analog immunoassay and tandem mass spectrometry. Clin Chem 2011;57:122-7.
22. Li G, Liu B, Liu Y. A dynamical model of the pulsatile secretion of the hypothalamo-pituitary-thyroid axis. BioSystems 1995;35:83-92.
23. Shupnik MA, Chin WW, Habener JF, et al. Transcriptional regulation of the thyrotropin subunit genes by thyroid hormone. J Biol Chem 1985;260:2900-3.
24. Prummel MF, Brokken LJS, Wiersinga WM. Ultra short-loop feedback control of thyrotropin secretion. Thyroid 2004;14:825-9.
25. Steinfelder HJ, Hauser P, Nakayama Y, et al. Thyrotropin-releasing hormone regulation of human TSHB expression: Role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element. Proc Natl Acad Sci USA 1991;88:3130-4.
26. Lazar MA. Thyroid hormone action: A binding contract. J Clin Invest 2003;112:497-9.
27. Cheng S-Y, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocr Rev 2010;31:139-70.
28. Shupnik MA, Ardisson LJ, Meskell MJ, et al. Triiodothyronine (T3) regulation of thyrotropin subunit gene transcription is proportional to T3 nuclear receptor occupancy. Endocrinology 1986;118:367-71.
29. Burman KD, Latham KR, Djuh YY, et al. Solubilized nuclear thyroid hormone receptors in circulating human mononuclear cells. J Clin EndocrinolMetab 1980;51:106-16.
30. Kvetny J, Wandrup J. Nuclear thyroxine binding in human mononuclear blood cells from hyperthyroid and hypothyroid patients before and after treatment. Scand J Clin Lab Invest 1986;46:489-93.
31. Lazar MA. Thyroid hormone receptors: Multiple forms, multiple possibilities. Endocr Rev 1993;14:184-93.
32. Langlois MF, Zanger K, Monden T, et al. A unique role of the beta-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone. Mapping of a novel amino-terminal domain important for ligand-independent activation. J Biol Chem 1997;272:24927-33.
33. Lee S, Young BM, Wan W, et al. A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: A loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2. Mol Endocrinol 2011;25:1111-25.
34. Wan W, Farboud B, Privalsky ML. Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function. Mol Endocrinol 2005;19:1529-42.
35. Persani L, Borgato S, Romoli R, et al. Changes in the degree of sialylation of carbohydrate chains modify the biological properties of circulating thyrotropin isoforms in various physiological and pathological states. Clin Endocrinol 1998;83:2486-92.
36. Chiamolera MI, Wondisford FE. Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism. Endocrinology 2009;150:1091-6.
37. Marsili A, Sanchez E, Singru P, et al. Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase. J Endocrinol 2011;211:73-8.
38. Maia AL, Goemann IM, Meyer ELS, et al. Type 1 iodothyronine deiodinase in human physiology and disease: Deiodinases: The balance of thyroid hormone. J Endocrinol 2011;209:283-97.
39. Hansen PS, Brix TH, Sørensen TIA, et al. Major genetic influence on the regulation of the pituitary-thyroid axis: A study of healthy Danish twins. J Clin Endocrinol Metab 2004;89:1181-7.
40. Hoftijzer HC, Heemstra KA, Visser TJ, et al. The type 2 deiodinase ORFa-Gly3Asp polymorphism (rs12885300) influences the set point of the hypothalamuspituitary-thyroid axis in patients treated for differentiated thyroid carcinoma. J Clin Endocrinol Metab 2011;96:E1527-33.
41. Visser WE, Friesema ECH, Visser TJ. Minireview: Thyroid hormone transporters: The knowns and the unknowns. Mol Endocrinol 2011;25:1-14.
42. Midgley JE. Direct and indirect free thyroxine assay methods: Theory and practice. Clin Chem 2001;47:1353-63.
43. Boelen A, Kwakkel J, Fliers E. Beyond low plasma T3: Local thyroid hormone metabolism during inflammation and infection. Endocr Rev 2011;32:670-93.
44. Asvold BO, Vatten LJ, Midthjell K, et al. Serum TSH within the reference range as a predictor of future hypothyroidism and hyperthyroidism: 11-year follow-up of the HUNT Study in Norway. J Clin Endocrinol Metab 2012;97:93-9.
45. Rothacker K, Hadlow NC, Wardrop R, et al. The relationship between TSH and free T4 is not log-linear and differs between genders and age groups: ASN Events. Aust Endocr Soc (Internet) 2012;1-3(Abstract). http://esa-srb-2012.m. asnevents.com.au (accessed 31 Aug 2012
46. Midgley JE. 'All that glisters is not gold': Ultrafiltration and free thyroxine measurement. With apologies to W Shakespeare. Clin Biochem 2011;44:151-3.