The relationship between serum TSH and free T4 in older people

Journal of Clinical Pathology

Volumn 65, Issue 5, 2012, Pages 463-465

  Clark, Penny M ^a   Holder, Roger L ^b   Haque, Sayeed M ^b   Hobbs, F D Richard ^b   Roberts, Lesley M ^b   Franklyn, Jayne A ^b  

^a UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

THYROTROPIN; THYROXINE;

AGED; AGING; ARTICLE; CROSS-SECTIONAL STUDY; FEMALE; FREE THYROXINE INDEX; GERIATRIC PATIENT; HORMONE DETERMINATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

AGE FACTORS; AGED; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; REFERENCE VALUES; SEX FACTORS; SMOKING; THYROID GLAND; THYROTROPIN; THYROXINE;

EID: 84860758059     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2011-200433     Document Type: Article

References (12)

1. Andersen S, Pedersen KM, Bruun NH, et al. Narrow individual variations in serum T4 and T3 in normal subjects: a clue to the understanding of subclinical hypothyroidism. J Clin Endocrinol Metab 2002;87:1068-72. (Pubitemid 36121067)
2. Hansen PS, Brix TH, Sørensen TI, et al. Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins. J Clin Endocrinol Metab 2004;89:1181-7. (Pubitemid 38368409)
3. Panicker V, Cluett C, Shields B, et al. A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab 2008;93:3075-81.
4. Boucai L, Surks MI. Reference limits of serum TSH and free T4 are significantly influenced by race and age in an urban outpatient medical practiced. Clin Endocrinol (Oxf) 2009;70:788-93.
5. Spencer CA, LoPresti JS, Guttler RB, et al. Applications of a new chemiluminometric thyrotropin assay to subnormal measurement. J Clin Endocrinol Metab 1990;70:453-60.
6. Ercan-Fang S, Schwartz HL, Mariash CN, et al. Quantitative assessment of pituitary resistance to thyroid hormone from plots of the logarithm of thyrotropin versus serum free thyroxine index. J Clin Endocrinol Metab 2000;85:2299-303. (Pubitemid 32269259)
7. Benhadi N, Fliers E, Visser TJ, et al. Pilot study on the assessment of the setpoint of the hypothalamus-pituitary axis in healthy volunteers. Eur J Endocrinol 2010;162:323-9.
8. Wilson S, Parle JV, Roberts LM, et al; on behalf of the Birmingham Elderly Thyroid Study Team. Prevalence of subclinical thyroid dysfunction and its relation to socioeconomic deprivation in the elderly: a community-based cross-sectional survey. J Clin Endocrinol Metab 2006;91:4809-16. (Pubitemid 44917312)
9. Beckett G, MacKenzie F. Thyroid guidelines - are thyroid-stimulating hormone assays fit for purpose? Ann Clin Biochem 2007;44:203-8. (Pubitemid 351724686)
10. Thienpont LM, Van Uytfanghe K, Beastall G, et al. Report of the IFCC Working Group for standardization of thyroid function tests; Part 2: free thyroxine and free triiodothyronine. Clin Chem 2010;56:912-20.
11. Van Deventer HE, Mendu DR, Remaley AT, et al. Inverse log-linear relationship between thyroid-stimulating hormone and free thyroxine measured by direct analog immunoassay and tandem mass spectrometry. Clin Chem 2011;57:122-7.
12. Jonklaas J, Kahric-Janicic N, Soldin OP, et al. Correlations of free thyroid hormones measured by tandem mass spectrometry and immunoassay with thyroid-stimulating hormone across 4 patient populations. Clin Chem 2009;55:1380-8.