Bacterial signatures in thrombus aspirates of patients with myocardial infarction

Circulation

Volumn 127, Issue 11, 2013, Pages 1219-1228

  Pessi, Tanja ^a   Karhunen, Vesa ^a,b   Karjalainen, Pasi P ^c   Ylitalo, Antti ^c   Airaksinen, Juhani K ^d   Niemi, Matti ^c   Pietila, Mikko ^d   Lounatmaa, Kari ^e   Haapaniemi, Teppo ^f   Lehtimäki, Terho ^a   Laaksonen, Reijo ^a   Karhunen, Pekka J ^a,g   Mikkelsson, Jussi ^a,c  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c SATAKUNTA CENTRAL HOSPITAL   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e Lounatmaa Ltd   (Finland)

^f BioSiteHisto Ltd   (Finland)

^g UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Bacteria; Inflammation; Myocardial infarction; Thrombosis; Viridans streptococci

Indexed keywords

BACTERIAL DNA; CD14 ANTIGEN; CD68 ANTIGEN;

ADULT; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ALPHA HEMOLYTIC STREPTOCOCCUS; ARTERIAL BLOOD; ARTICLE; BACTERIAL CELL; BACTERIAL INFECTION; BACTERIUM DETECTION; BLOOD SAMPLING; CHLAMYDOPHILA PNEUMONIAE; COHORT ANALYSIS; CORONARY ARTERY THROMBOSIS; DIALISTER PNEUMOSINTES; FEMALE; FUSOBACTERIUM NUCLEATUM; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MOUTH INFECTION; NONHUMAN; PANORAMIC RADIOGRAPHY; PARVIMONAS MICRA; PERCUTANEOUS CORONARY INTERVENTION; PERIODONTAL DISEASE; PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STREPTOCOCCUS; STREPTOCOCCUS ANGINOSUS; STREPTOCOCCUS MITIS; STREPTOCOCCUS ORALIS; THROMBUS ASPIRATION; TOOTH INFECTION; TOOTH PERIAPICAL DISEASE; TRANSMISSION ELECTRON MICROSCOPY; TREPONEMA DENTICOLA;

ANTIGENS, CD; ANTIGENS, CD14; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BIOLOGICAL MARKERS; BIOPSY, NEEDLE; DNA, BACTERIAL; FEMALE; HUMANS; MACROPHAGES; MALE; MIDDLE AGED; MOUTH DISEASES; MYOCARDIAL INFARCTION; RETROSPECTIVE STUDIES; STOMATOGNATHIC DISEASES; THROMBOSIS; VIRIDANS STREPTOCOCCI;

EID: 84875212648     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.001254     Document Type: Article

References (49)

1. Vainas T, Sayed S, Bruggeman CA, Stassen FR. Exploring the role of Chlamydia pneumoniae in cardiovascular disease: a narrative review. Drugs Today. 2009;45(suppl B):165-172.
2. Cannon CP, Braunwald E, McCabe CH, Grayston JT, Muhlestein B, Giugliano RP, Cairns R, Skene AM; Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators. Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndrome. N Engl J Med. 2005;352:1646-1654.
3. Chiu B. Multiple infections in carotid atherosclerotic plaques. Am Heart J. 1999;138(pt 2):S534-S536.
4. Haraszthy VI, Zambon JJ, Trevisan M, Zeid M, Genco RJ. Identification of periodontal pathogens in atheromatous plaques. J Periodontol. 2000;71:1554-1560.
5. Ishihara K, Nabuchi A, Ito R, Miyachi K, Kuramitsu HK, Okuda K. Correlation between detection rates of periodontopathic bacterial DNA in coronary stenotic artery plaque [corrected] and in dental plaque samples. J Clin Microbiol. 2004;42:1313-1315.
6. Okuda K, Ishihara K, Nakagawa T, Hirayama A, Inayama Y, Okuda K. Detection of Treponema denticola in atherosclerotic lesions. J Clin Microbiol. 2001;39:1114-1117.
7. Stelzel M, Conrads G, Pankuweit S, Maisch B, Vogt S, Moosdorf R, Flores-de-Jacoby L. Detection of Porphyromonas gingivalis DNA in aortic tissue by PCR. J Periodontol. 2002;73:868-870.
8. Lehtiniemi J, Karhunen PJ, Goebeler S, Nikkari S, Nikkari ST. Identification of different bacterial DNAs in human coronary arteries. Eur J Clin Invest. 2005;35:13-16.
9. Ott SJ, El Mokhtari NE, Musfeldt M, Hellmig S, Freitag S, Rehman A, Kühbacher T, Nikolaus S, Namsolleck P, Blaut M, Hampe J, Sahly H, Reinecke A, Haake N, Günther R, Krüger D, Lins M, Herrmann G, Fölsch UR, Simon R, Schreiber S. Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease. Circulation. 2006;113:929-937.
10. Kozarov E, Sweier D, Shelburne C, Progulske-Fox A, Lopatin D. Detection of bacterial DNA in atheromatous plaques by quantitative PCR. Microbes Infect. 2006;8:687-693.
11. Koren O, Spor A, Felin J, Fåk F, Stombaugh J, Tremaroli V, Behre CJ, Knight R, Fagerberg B, Ley RE, Bäckhed F. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc Natl Acad Sci U S A. 2011;108(suppl 1):4592-4598.
12. Joshipura KJ, Rimm EB, Douglass CW, Trichopoulos D, Ascherio A, Willett WC. Poor oral health and coronary heart disease. J Dent Res. 1996;75:1631-1636.
13. Mattila KJ, Nieminen MS, Valtonen VV, Rasi VP, Kesäniemi YA, Syrjälä SL, Jungell PS, Isoluoma M, Hietaniemi K, Jokinen MJ. Association between dental health and acute myocardial infarction. BMJ. 1989;298:779-781.
14. Spahr A, Klein E, Khuseyinova N, Boeckh C, Muche R, Kunze M, Rothenbacher D, Pezeshki G, Hoffmeister A, Koenig W. Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study. Arch Intern Med. 2006;166:554-559.
15. Mendez MV, Scott T, LaMorte W, Vokonas P, Menzoian JO, Garcia R. An association between periodontal disease and peripheral vascular disease. Am J Surg. 1998;176:153-157.
16. Blaizot A, Vergnes JN, Nuwwareh S, Amar J, Sixou M. Periodontal diseases and cardiovascular events: meta-analysis of observational studies. Int Dent J. 2009;59:197-209.
17. Buhlin K, Mäntylä P, Paju S, Peltola JS, Nieminen MS, Sinisalo J, Pussinen PJ. Periodontitis is associated with angiographically verified coronary artery disease. J Clin Periodontol. 2011;38:1007-1014.
18. Ohki T, Itabashi Y, Kohno T, Yoshizawa A, Nishikubo S, Watanabe S, Yamane G, Ishihara K. Detection of periodontal bacteria in thrombi of patients with acute myocardial infarction by polymerase chain reaction. Am Heart J. 2012;163:164-167.
19. Karhunen V, Forss H, Goebeler S, Huhtala H, Ilveskoski E, Kajander O, Mikkelsson J, Penttilä A, Perola M, Ranta H, Meurman JH, Karhunen PJ. Radiographic assessment of dental health in middle-aged men following sudden cardiac death. J Dent Res. 2006;85:89-93.
20. Hamp SE, Nyman S, Lindhe J. Periodontal treatment of multirooted teeth: results after 5 years. J Clin Periodontol. 1975;2:126-135.
21. Suzuki N, Yoshida A, Nakano Y. Quantitative analysis of multi-species oral biofilms by TaqMan real-time PCR. Clin Med Res. 2005;3:176-185.
22. Gardner M, Gardner S, Winter P, eds. Confidence Interval Analysis (CIA): Microcomputer Program Manual and Disk. Version 1.0 ed. London, UK: BMJ Books (Manual); 1989.
23. Bland JM, Altman DG. Multiple significance tests: the Bonferroni method. BMJ. 1995;310:170.
24. Doern CD, Burnham CA. It's not easy being green: the viridans group streptococci, with a focus on pediatric clinical manifestations. J Clin Microbiol. 2010;48:3829-3835.
25. Rozkiewicz D, Daniluk T, Sciepuk M, Zaremba ML, Cylwik-Rokicka D, Luczaj-Cepowicz E, Milewska R, Marczuk-Kolada G, Stokowska W. Prevalence rate and antibiotic susceptibility of oral viridans group streptococci (VGS) in healthy children population. Adv Med Sci. 2006;51(suppl 1):191-195.
26. Williams BL, McCann GF, Schoenknecht FD. Bacteriology of dental abscesses of endodontic origin. J Clin Microbiol. 1983;18:770-774.
27. Kolenbrander PE, Palmer RJ Jr, Periasamy S, Jakubovics NS. Oral multispecies biofilm development and the key role of cell-cell distance. Nat Rev Microbiol. 2010;8:471-480.
28. Nagata E, de Toledo A, Oho T. Invasion of human aortic endothelial cells by oral viridans group streptococci and induction of inflammatory cytokine production. Mol Oral Microbiol. 2011;26:78-88.
29. Herzberg MC, Nobbs A, Tao L, Kilic A, Beckman E, Khammanivong A, Zhang Y. Oral streptococci and cardiovascular disease: searching for the platelet aggregation-associated protein gene and mechanisms of Streptococcus sanguis-induced thrombosis. J Periodontol. 2005;76(suppl):2101-2105.
30. Petersen HJ, Keane C, Jenkinson HF, Vickerman MM, Jesionowski A, Waterhouse JC, Cox D, Kerrigan SW. Human platelets recognize a novel surface protein, PadA, on Streptococcus gordonii through a unique interaction involving fibrinogen receptor GPIIbIIIa. Infect Immun. 2010;78:413-422.
31. Lebeer S, Vanderleyden J, De Keersmaecker SC. Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nat Rev Microbiol. 2010;8:171-184.
32. Hajishengallis G, Sharma A, Russell MW, Genco RJ. Interactions of oral pathogens with toll-like receptors: possible role in atherosclerosis. Ann Periodontol. 2002;7:72-78.
33. Sugawara S, Arakaki R, Rikiishi H, Takada H. Lipoteichoic acid acts as an antagonist and an agonist of lipopolysaccharide on human gingival fibroblasts and monocytes in a CD14-dependent manner. Infect Immun. 1999;67:1623-1632.
34. Cojocaru E, Trandafirescu M, Leon M, Cotuţiu C, Foia L. Immunohistochemical expression of anti-CD68 antibody in atherosclerotic plaque. Rom J Morphol Embryol. 2012;53:61-66.
35. Wade WG. The oral microbiome in health and disease [published online ahead of print November 28, 2012]. Pharmacol Res. doi:10.1016/j.phrs.2012.11. 006.
36. Power DA, Cordiner SJ, Kieser JA, Tompkins GR, Horswell J. PCR-based detection of salivary bacteria as a marker of expirated blood. Sci Justice. 2010;50:59-63.
37. Li X, Kolltveit KM, Tronstad L, Olsen I. Systemic diseases caused by oral infection. Clin Microbiol Rev. 2000;13:547-558.
38. Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK. Bacteremia associated with toothbrushing and dental extraction. Circulation. 2008;117:3118-3125.
39. Olsen I. Update on bacteraemia related to dental procedures. Transfus Apher Sci. 2008;39:173-178.
40. Tomás I, Alvarez M, Limeres J, Potel C, Medina J, Diz P. Prevalence, duration and aetiology of bacteraemia following dental extractions. Oral Dis. 2007;13:56-62.
41. Van der Meer JJ, van der Wal AC, Teeling P, Idu MM, van der Ende A, de Boer OJ. Multiple bacteria contribute to intraplaque T-cell activation in atherosclerosis. Eur J Clin Invest. 2008;38:857-862.
42. Kozarov EV, Dorn BR, Shelburne CE, Dunn WA Jr, Progulske-Fox A. Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Arterioscler Thromb Vasc Biol. 2005;25:e17-e18.
43. Rafferty B, Dolgilevich S, Kalachikov S, Morozova I, Ju J, Whittier S, Nowygrod R, Kozarov E. Cultivation of Enterobacter hormaechei from human atherosclerotic tissue. J Atheroscler Thromb. 2011;18:72-81.
44. Rafferty B, Jönsson D, Kalachikov S, Demmer RT, Nowygrod R, Elkind MS, Bush H Jr, Kozarov E. Impact of monocytic cells on recovery of uncultivable bacteria from atherosclerotic lesions. J Intern Med. 2011;270:273-280.
45. Ramirez JA. Isolation of Chlamydia pneumoniae from the coronary artery of a patient with coronary atherosclerosis: the Chlamydia pneumoniae/ Atherosclerosis Study Group. Ann Intern Med. 1996;125:979-982.
46. Elkind MS, Luna JM, Moon YP, Boden-Albala B, Liu KM, Spitalnik S, Rundek T, Sacco RL, Paik MC. Infectious burden and carotid plaque thickness: the Northern Manhattan Study. Stroke. 2010;41: e117-e122.
47. Thomas M, Wong Y, Thomas D, Ajaz M, Tsang V, Gallagher PJ, Ward ME. Relation between direct detection of Chlamydia pneumoniae DNA in human coronary arteries at postmortem examination and histological severity (Stary grading) of associated atherosclerotic plaque. Circulation. 1999;99:2733-2736.
48. Kramer MC, van der Wal AC, Koch KT, Rittersma SZ, Li X, Ploegmakers HP, Henriques JP, van der Schaaf RJ, Baan J Jr, Vis MM, Meesterman MG, Piek JJ, Tijssen JG, de Winter RJ. Histopathological features of aspirated thrombi after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction. PLoS ONE. 2009;4:e5817.
49. Vlaar PJ, Svilaas T, Vogelzang M, Diercks GF, de Smet BJ, van den Heuvel AF, Anthonio RL, Jessurun GA, Tan E, Suurmeijer AJ, Zijlstra F. A comparison of 2 thrombus aspiration devices with histopathological analysis of retrieved material in patients presenting with ST-segment elevation myocardial infarction. JACC Cardiovasc Interv. 2008;1:258-264.