Human platelets recognize a novel surface protein, PadA, on Streptococcus gordonii through a unique interaction involving fibrinogen receptor GPIIbIIIa

Infection and Immunity

Volumn 78, Issue 1, 2010, Pages 413-422

  Petersen, Helen J ^a   Keane, Ciara ^b   Jenkinson, Howard F ^a   Vickerman, M Margaret ^c   Jesionowski, Amy ^c   Waterhouse, Janet C ^c   Cox, Dermot ^b   Kerrigan, Steven W ^b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; BACTERIAL PROTEIN; FETUIN; FIBRINOGEN RECEPTOR; MEMBRANE PROTEIN; MUTANT PROTEIN; POLYPEPTIDE; PROTEIN PADA; RECOMBINANT PROTEIN; THROMBOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL CELL; BACTERIAL GENE; BACTERIUM MUTANT; CHO CELL; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; STRAIN DIFFERENCE; STREPTOCOCCUS GORDONII; THROMBOCYTE; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE; THROMBOSIS; WILD TYPE;

ANIMALS; ANTIBODIES, MONOCLONAL; BACTERIAL PROTEINS; BLOOD PLATELETS; CELLS, CULTURED; CHO CELLS; COMPUTATIONAL BIOLOGY; CRICETINAE; CRICETULUS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MEMBRANE PROTEINS; MUTATION; PLATELET ADHESIVENESS; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; STREPTOCOCCUS GORDONII;

EID: 73449137237     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00664-09     Document Type: Article

References (37)

1. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
2. Barrau, K., A. Boulamery, G. Imbert, J. P. Casalta, G. Habib, T. Messana, J. L. Bonnet, E. Rubinstein, and D. Raoult. 2004. Causative organisms of infective endocarditis according to host status. Clin. Microbiol. Infect. 10: 302-308.
3. Bateman, A., M. T. G. Holden, and C. Yeats. 2005. The G5 domain: a potential N-acetylglucosamine recognition domain involved in biofilm formation. Bioinformatics 21:1301-1303.
4. Bendtsen, J. D., H. Nielsen, G. von Heijne, and S. Brunak. 2004. Improved prediction of signal peptides: SignalP 3.0. J. Mol. Biol. 340:783-795.
5. Bensing, B. A., J. A. Lopez, and P. A. Sullam. 2004. The Streptococcus gordonii surface proteins GspB and Hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein Ibα. Infect. Immun. 72:6528-6537.
6. Beynon, R. P., V. K. Bahl, and B. D. Prendergast. 2006. Infective endocarditis. BMJ 333:334-339.
7. Demuth, D. R., Y. Duan, H. F. Jenkinson, R. Mcnab, S. Gil, and R. J. Lamont. 1997. Interruption of the Streptococcus gordonii M5 sspA/sspB intergenic region by an insertion sequence related to IS1167 of Streptococcus pneumoniae. Microbiology 143:2047-2055.
8. Fitzgerald, J. R., T. J. Foster, and D. Cox. 2006. The interaction of bacterial pathogens with platelets. Nat. Rev. Microbiol. 4:445-457.
9. Herzberg, M. C., G. D. Macfarlane, K. E. Gong, N. N. Armstrong, A. R. Witt, P. R. Erickson, and M. W. Meyer. 1992. The platelet interactivity phenotype of Streptococcus sanguis influences the course of experimental endocarditis. Infect. Immun. 60:4809-4818.
10. Jakubovics, N. S., S. W. Kerrigan, A. H. Nobbs, N. Stromberg, C. J. van Dolleweerd, D. M. Cox, C. G. Kelly, and H. F. Jenkinson. 2005. Functions of cell surface-anchored antigen I/II family and Hsa polypeptides in interactions of Streptococcus gordonii with host receptors. Infect. Immun. 73:6629-6638.
11. 2+) permease in Streptococcus gordonii is regulated by a diphtheria toxin metallorepressor-like protein ScaR. Mol. Microbiol. 38:140-153.
12. Jakubovics, N. S., N. Stromberg, C. J. van Dolleweerd, C. G. Kelly, and H. F. Jenkinson. 2005. Differential binding specificities of oral streptococcal antigen I/II family adhesins for human or bacterial ligands. Mol. Microbiol. 55:1591-1605.
13. Jenkinson, H. F. 1986. Cell-surface proteins of Streptococcus sanguis associated with cell hydrophobicity and coaggregation properties. J. Gen. Microbiol. 132:1575-1589.
14. Jenkinson, H. F., S. D. Terry, R. Mcnab, and G. W. Tannock. 1993. Inactivation of the gene encoding surface protein SspA in Streptococcus gordonii DL1 affects cell interactions with human salivary agglutinin and oral actinomyces. Infect. Immun. 61:3199-3208.
15. Kerrigan, S. W., N. S. Jakubovics, C. Keane, P. Maguire, K. Wynne, H. F. Jenkinson, and D. Cox. 2007. Role of Streptococcus gordonii surface proteins SspA/SspB and Hsa in platelet function. Infect. Immun. 75:5740-5747.
16. Lawson, J. W., and H. Gooder. 1970. Growth and development of competence in group H streptococci. J. Bacteriol. 102:820.
17. Leblanc, D. J., L. N. Lee, and J. M. Inamine. 1991. Cloning and nucleotide base sequence analysis of a spectinomycin adenyltransferase aad9 determinant from Enterococcus faecalis. Antimicrob. Agents Chemother. 35:1804-1810.
18. Loferer, H., M. Bott, and H. Hennecke. 1993. Bradyrhizobium japonicum TlpA, a novel membrane anchored thioredoxin-like protein involved in the biogenesis of cytochrome aa3 and development of symbiosis. EMBO J. 12:3373-3383.
19. Lombardo, V. T., E. Hodson, J. R. Roberts, T. J. Kunicki, T. S. Zimmerman, and Z. M. Ruggeri. 1985. Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody. J. Clin. Invest. 76:1950-1958.
20. Loughman, A., J. R. Fitzgerald, M. P. Brennan, J. Higgins, R. Downer, D. Cox, and T. J. Foster. 2005. Roles for fibrinogen, immunoglobulin and complement in platelet activation promoted by Staphylococcus aureus clumping factor A. Mol. Microbiol. 57:804-818.
21. Marchler-Bauer, A., J. B. Anderson, P. F. Cherukuri, C. DeWweese-Scott, L. Y. Geer, M. Gwadz, S. Q. He, D. I. Hurwitz, J. D. Jackson, Z. X. Ke, C. J. Lanczycki, C. A. Liebert, C. L. Liu, F. Lu, G. H. Marchler, M. Mullokandov, B. A. Shoemaker, V. Simonyan, J. S. Song, P. A. Thiessen, R. A. Yamashita, J. J. Yin, D. C. Zhang, and S. H. Bryant. 2005. CDD: a conserved domain database for protein classification. Nucleic Acids Res. 33:D192-D196.
22. Nishio, K., Y. Fujimura, S. Nishida, I. Takeda, A. Yoshioka, H. Fukui, Y. Tomiyama, and Y. Kurata. 1991. Antiplatelet glycoprotein-Ib monoclonal antibody (Op-F1) totally abolishes ristocetin-induced von Willebrand factor binding, but has minimal effect on the botrocetin-induced binding. Haemostasis 21:353-359.
23. Nobbs, A. H., B. H. Shearer, M. Drobni, M. A. Jepson, and H. F. Jenkinson. 2007. Adherence and internalization of Streptococcus gordonii by epithelial cells involves β1 integrin recognition by SspA and SspB (antigen I/II family) polypeptides. Cell. Microbiol. 9:65-83.
24. Ruggeri, Z. M. 2003. Von Willebrand factor, platelets and endothelial cell interactions. J. Thromb. Haemost. 1:1335-1342.
25. Ruggeri, Z. M. 2009. Platelet adhesion under flow. Microcirculation 16:58-83.
26. Ruggeri, Z. M., and G. L. Mendolicchio. 2007. Adhesion mechanisms in platelet function. Circ. Res. 100:1673-1685.
27. Sadler, J. E. 1998. Biochemistry and genetics of von Willebrand factor. Annu. Rev. Biochem. 67:395-424.
28. Savage, B., S. J. Shattil, and Z. M. Ruggeri. 1992. Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin αIIbβ3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. J. Biol. Chem. 5:11300-11306.
29. Schneewind, O., D. Mihaylovapetkov, and P. Model. 1993. Cell-wall sorting signals in surface proteins of gram-positive bacteria. EMBO J. 12:4803-4811.
30. Sulavik, M. C., and D. B. Clewell. 1996. Rgg is a positive transcriptional regulator of the Streptococcus gordonii gtfG gene. J. Bacteriol. 178:5826-5830.
31. Takahashi, Y., A. L. Sandberg, S. Ruhl, J. Muller, and J. O. Cisar. 1997. A specific cell surface antigen of Streptococcus gordonii is associated with bacterial hemagglutination and adhesion to α2-3-linked sialic acid-containing receptors. Infect. Immun. 65:5042-5051.
32. Takahashi, Y., A. Yajima, J. O. Cisar, and K. Konishi. 2004. Functional analysis of the Streptococcus gordonii DL1 sialic acid-binding adhesin and its essential role in bacterial binding to platelets. Infect. Immun. 72:3876-3882.
33. Takamatsu, D., B. A. Bensing, H. Cheng, G. A. Jarvis, I. R. Siboo, J. A. Lopez, J. M. Griffiss, and P. M. Sullam. 2005. Binding of the Streptococcus gordonii surface glycoproteins GspB and Hsa to specific carbohydrate structures on platelet membrane glycoprotein Ibα. Mol. Microbiol. 58:380-392.
34. Vuillard, L., C. Braunbreton, and T. Rabilloud. 1995. Non-detergent sulfobetaines -a new class of mild solubilization agents for protein purification. Biochem. J. 305:337-343.
35. Wagner, C. L., M. A. Mascelli, D. S. Neblock, H. F. Weisman, B. S. Coller, and R. E. Jordan. 1996. Analysis of GPIIb/IIIa receptor number by quanti-fication of 7E3 binding to human platelets. Blood 88:907-914.
36. Yajima, A., Y. Takahashi, and K. Konishi. 2005. Identification of platelet receptors for the Streptococcus gordonii DL1 sialic acid-binding adhesin. Microbiol. Immunol. 49:795-800.
37. Zuker, M. 2003. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31:3406-3415.