Continuous direct tablet compression: Effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release

Drug Development and Industrial Pharmacy

Volumn 39, Issue 11, 2013, Pages 1802-1808

  Järvinen, Maiju A ^a   Paaso, Janne ^b   Paavola, Marko ^c   Leiviskä, Kauko ^c   Juuti, Mikko ^b   Muzzio, Fernando ^d   Järvinen, Kristiina ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c UNIVERSITY OF OULU   (Finland)

^d The State University of New Jersey   (United States)

Author keywords

Acetaminophen; Content uniformity; Continuous direct tablet compression; Continuous powder mixing; Crushing strength; Dissolution; Tablet mechanical properties

Indexed keywords

MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; PARACETAMOL; SILICON DIOXIDE;

ARTICLE; CONTROLLED STUDY; DRUG RELEASE; DRUG SOLUBILITY; FORCE; PROCESS CONTROL; ROTATION; STEADY STATE; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET FRIABILITY; TABLET MANUFACTURE; TABLET PROPERTY; TENSILE STRENGTH;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; AUTOMATION; CELLULOSE; COLLOIDS; DRUG COMPOUNDING; EXCIPIENTS; FINLAND; HARDNESS; KINETICS; MECHANICAL PHENOMENA; MODELS, MOLECULAR; PHYSICOCHEMICAL PHENOMENA; QUALITY CONTROL; SILICON DIOXIDE; SOLUBILITY; STEARIC ACIDS; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TENSILE STRENGTH;

EID: 84875210684     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.738681     Document Type: Article

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