Effects of rotation rate, mixing angle, and cohesion in two continuous powder mixers-A statistical approach

Powder Technology

Volumn 194, Issue 3, 2009, Pages 217-227

  Portillo, Patricia M ^a   Ierapetritou, Marianthi G ^a   Muzzio, Fernando J ^a  

^a The State University of New Jersey   (United States)

Author keywords

ANOVA; Continuous powder mixing; Homogeneity; Residence time; Statistical analysis

Indexed keywords

ANOVA; CONTINUOUS POWDER MIXING; HOMOGENEITY; RESIDENCE TIME; STATISTICAL ANALYSIS;

ADHESION; ANALYSIS OF VARIANCE (ANOVA); MIXERS (MACHINERY); POWDERS; REGRESSION ANALYSIS; ROTATION;

MIXING;

ANALYSIS OF VARIANCE; ARTICLE; CONTROLLED STUDY; MIXER; POWDER; PROCESS TECHNOLOGY; PROCESSING; ROTATION; STATISTICAL ANALYSIS;

EID: 67349120638     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2009.04.010     Document Type: Article

References (27)

1. Muzzio F.J., Shinbrot T., and Glasser B.J. Powder technology in the pharmaceutical industry: the need to catch up fast. Powder Technology 124 (2002) 1-7
2. FDA, Guidance for Industry, Powder Blends and Finished Dosage Units - Stratified In-Process Dosage Unit Sampling and Assessment, Pharmaceutical CGMP's, October 2003.
3. Portillo P.M., Ierapetritou M.G., and Muzzio F.J. Characterization of continuous convective powder mixing processes. Powder Technology 182 (2008) 368-379
4. Fan L.T., Chen S.J., and Watson C.A. Solid mixing. Industrial and Engineering Chemistry 62 7 (1970) 53-69
5. Wightman C., and Muzzio F.J. Mixing of granular material in a drum mixer undergoing rotational and rocking motions I. Uniform particles. Powder Technology 98 2 (1998) 113-124
6. Brone D., Wightman C., Connor K., Alexander A., Muzzio F., and Robinson P. Using flow perturbations to enhance mixing of dry powders in V-blenders. Powder Technology 91 3 (1997) 165-172
7. Brone D., Alexander A., and Muzzio F. Quantitative characterization of mixing of dry powders in V-blenders. AICHE 44 2 (1998) 271-278
8. Alexander A., Muzzio F., and Shinbrot T. Segregation patterns in V-blenders. Chemical Engineering Science 58 2 (2003) 487-496
9. Alexander A., Shinbrot T., Johnson B., and Muzzio F.J. V-blender segregation patterns for free-flowing materials: effects of blender capacity and fill level. International Journal of Pharmaceutics 269 1 (2004) 19-28
10. Lemieux M., Bertrand F., Chaouki J., and Gosselin P. Comparative study of the mixing of free-flowing particles in a V-blender and a bin-blender. Chemical Engineering Science 62 (2007) 1783-1802
11. Brone D., and Muzzio F.J. Enhanced mixing in double-cone blenders. Powder Technology 110 (2000) 179-189
12. Sudah O.S., Coffin-Beach D., and Muzzio F.J. Effects of blender rotational speed and discharge on the homogeneity of cohesive and free-flowing mixtures. International Journal of Pharmaceutics 247 (2002) 57-68
13. Arratia P.E., Duong N.-H., Muzzio F.J., Godbole P., Lange A., and Reynolds S. Characterizing mixing and lubrication in the Bohle Bin blender. Powder Technology 161 (2006) 202-208
14. Portillo P.M., Ierapetritou M.G., Tomassone S., McDade C., Clancy D., Avontuur P.C., and Muzzio F.J. Quality by design methodology for development and scale-up of batch mixing processes 3 4 (2008) 258-270
15. Muzzio F.J., Llusa M., Goodridge C.L., Duong N.-H., and Shen E. Evaluating the mixing performance of a ribbon blender. Powder Technology 186 3 (2008) 247-254
16. Marikh K., Berthiaux H., Mizonov V., and Barantseva E. Experimental study of the stirring conditions taking place in a pilot plant continuous mixer of particulate solids. Powder Technology 157 (2005) 138-143
17. Harwood C., Walanski K., Luebcke E., and Swanstrom C. The performance of continuous mixers for dry powders. Powder Technology 11 (1975) 289-296
18. Rollins D., Faust D., and Jabas D. A superior approach to indices in determining mixture segregation. Powder Technology 84 (1995) 277-282
19. Hou T., Su C., and Liu W. Parameters optimization of a nano-particle wet milling process using the Taguchi method, response surface method and genetic algorithm. Powder Technology 173 (2007) 153-162
20. Walker J., and Rollins D. Detecting powder mixture inhomogeneity for non-normal measurement errors. Powder Technology 92 (1997) 9-15
21. DMV Product group overview, Pharmatose® milled & sieved lactose.
22. Sánchez F.C., Toft J., van den Bogaert B., Massart D.L., Dive S.S., and Hailey P. Monitoring powder blending by NIR spectroscopy. Fresenius' Journal of Analytical Chemistry 352 (1995) Numbers 7-8 / January, 1995
23. Sudah O.S., Chester A.W., Kowalski J.A., Beeckman J.W., and Muzzio F.J. Quantitative characterization of mixing processes in rotary calciners. Powder Technology 126 (2002) 166-173
24. Muzzio F.J., Alexander A., Goodridge C., Shen E., and Shinbrot T. Solid Mixing. In: Paul E., Atiemo-Obeng V.A., and Kresta S.M. (Eds). Handbook of Industrial Mixing: Science and Practice (2004), John Wiley & Sons, Inc.
25. Bridgwater J., Broadbent C.J., and Parker D.J. Study of the influence of blade speed on the performance of a powder mixer using positron emission particle tracking. Transactions of the IchemE 71A (1993) 675-681
26. Lacey P.M.C. Mixing of solid particles. Trans. Inst. Chem. Eng. 21 (1943) 53-59
27. Harwood C., Walanski K., Luebcke E., and Swanstrom C. The Performance of Continuous mixers for dry powders. Powder Technology 11 (1975) 289-296