Triplex-forming peptide nucleic acids induce heritable elevations in gamma-globin expression in hematopoietic progenitor cells

Molecular Therapy

Volumn 21, Issue 3, 2013, Pages 580-587

  Chin, Joanna Y ^a   Reza, Faisal ^a   Glazer, Peter M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN F; HEMOGLOBIN GAMMA CHAIN; PEPTIDE NUCLEIC ACID; SINGLE STRANDED DNA;

ANIMAL CELL; ARTICLE; BINDING SITE; BONE MARROW CELL; COMPLEX FORMATION; CONTROLLED STUDY; DNA RECOMBINATION; DRUG MECHANISM; GAMMA GLOBIN GENE; GENE TARGETING; HEMATOPOIETIC STEM CELL; HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN MUTATION; HUMAN; HUMAN CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OLIGONUCLEOTIDE THERAPY; OXYGEN TENSION; POINT MUTATION; PROMOTER REGION; PROTEIN EXPRESSION; TARGETED GENE REPAIR; UPREGULATION; YEAST ARTIFICIAL CHROMOSOME;

HARNESS; MAMMALIA;

EID: 84875210339     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.262     Document Type: Article

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