Molecular basis of hereditary persistence of fetal hemoglobin

Annals of the New York Academy of Sciences

Volumn 850, Issue , 1998, Pages 38-44

  Forget, Bernard G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; GAMMA GLOBIN; HEMOGLOBIN F; TRANSCRIPTION FACTOR;

BETA THALASSEMIA; CONFERENCE PAPER; DISEASE COURSE; ERYTHROID CELL; GENE DELETION; GENE EXPRESSION; GENE THERAPY; GLOBIN GENE; HUMAN; MOLECULAR BIOLOGY; POINT MUTATION; PROMOTER REGION; SICKLE CELL ANEMIA;

EID: 0031871713     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb10460.x     Document Type: Conference Paper

References (11)

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3. STAMATOYANNOPOULOS, G. & A. W. NIENHUIS. 1994. In Molecular Basis of Blood Diseases, 2nd edit. G. Stamatoyannopoulos A. W. Nienhuis, P. W. Majerus, H. E. Varmus, Eds.: 107-155. W. B. Saunders, Philadelphia.
4. KOSTEAS, T., A. PALENA & N. P. ANAGNOU. 1997. Molecular cloning of the breakpoints of the hereditary persistence of fetal hemoglobin Type-6 (HPFH-6) deletion and sequence analysis of the novel juxtaposed region from the 3′ end of the β-globin gene cluster. Hum. Genet. 100: 441-445.
5. FEINGOLD, E. A. & B. G. FORGET. 1989. The breakpoint of a large deletion causing hereditary persistence of fetal hemoglobin occurs within an erythroid DNA domain remote from the β-globin gene cluster. Blood 74: 2178-2186.
6. ELDER, J. T., W. C. FORRESTER & C. THOMPSON, et al. 1990. Translocation of an erythroid-specific hypersensitive site in deletion-type hereditary persistence of fetal hemoglobin. Mol. Cell. Biol. 10: 1382-1389.
7. ARCASOY, M. O. et al. 1997. High levels of human γ-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. Mol. Cell. Biol. 17: 2076-2089.
8. KOSTEAS, T. et al. 1996. Complete sequencing and functional analysis of the HPFH-6 enhancer: detection of multiple motifs for transcription factors and identification of an open reading frame. Blood 88(Suppl.1): 150a.
9. ANAGNOU, N. P. et al. 1995. Sequences located 3′ to the breakpoint of the hereditary persistence of fetal hemoglobin-3 deletion exhibit enhancer activity and can modify the developmental expression of the human fetal Aγ-globin gene in transgenic mice. J. Biol. Chem. 270: 10256-10263.
10. JANE, S. M., A. W. NIENHUIS & J. M. CUNNINGHAM. 1995. Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein. EMBO J. 14: 97-105.
11. JANE, S. M. et al. 1993. Methylation enhanced binding of Sp1 to the stage selector element of the human γ-globin gene promoter may regulate developmental specificity of expression. Mol. Cell. Biol. 13: 3272-3281.