Description of a bivalent cannabinoid ligand with hypophagic properties

Archiv der Pharmazie

Volumn 346, Issue 3, 2013, Pages 171-179

  Fernández Fernández, Cristina ^a   Decara, Juan ^b   Bermúdez Silva, Francisco J ^b   Sánchez, Eva ^c   Morales, Paula ^a   Gõmez Cañas, María ^d   Gõmez Ruíz, María ^d   Callado, Luis F ^e   Goya, Pilar ^a   Rodríguez De Fonseca, Fernando ^b   Martín, M Isabel ^c   Fernández Ruíz, Javier ^d   Meana, J Javier ^e   Jagerovic, Nadine ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b Hospital University Carlos Haya de Málaga   (Spain)

^c UNIVERSIDAD REY JUAN CARLOS   (Spain)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Bivalent ligand; Cannabinoid receptors; CB1; Food intake; Rimonabant

Indexed keywords

5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXYLATE ACID; 5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXYLATE ACID CHLORIDE; ANTIOBESITY AGENT; BIVALENT CANNABINOID LIGAND; CANNABINOID 1 RECEPTOR; N,N' BUTAN 1,4 DIYLBIS[5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE]; N,N' DECAN 1,10 DIYLBIS[5 (4 CHLOROPHENYL) 1 (2,4 ICHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE]; N,N' DODECAN 1,12 DIYLBIS[5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE]; N,N' HEPTAN 1,7 DIYLBIS[5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE]; N,N' HEXAN 1,6 DIYLBIS[5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE]; N,N' NONAN 1,9 DIYLBIS[5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE]; N,N' OCTAN 1,8 DIYLBIS[5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE]; N,N' PROPAN 1,3 DIYLBIS[5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE]; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CATALEPSY; CONTROLLED STUDY; DOSE RESPONSE; DRUG STRUCTURE; EVALUATION; FOOD INTAKE; HYPOTHERMIA; MALE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SYNTHESIS;

ANIMALS; CANNABINOID RECEPTOR ANTAGONISTS; CELL MEMBRANE; DRUG DESIGN; FEEDING BEHAVIOR; FOOD DEPRIVATION; HUMANS; LIGANDS; MALE; MICE; MICE, INBRED ICR; MOLECULAR STRUCTURE; PIPERIDINES; PREFRONTAL CORTEX; PROTEIN BINDING; PYRAZOLES; RADIOLIGAND ASSAY; RECEPTOR, CANNABINOID, CB1; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84875209654     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201200392     Document Type: Article

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