Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: Insights into macrotetrolide drug spectrum, potency and mode of action

Medical Mycology

Volumn 51, Issue 3, 2013, Pages 280-289

  Tebbets, Brad ^a   Yu, Zhiguo ^b   Stewart, Douglas ^a   Zhao, Li Xing ^c   Jiang, Yi ^c   Xu, Li Hua ^c   Andes, David ^b   Shen, Ben ^b   Klein, Bruce ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c YUNNAN UNIVERSITY   (China)

Author keywords

Drug discovery; Fungi; Macrotetrolide; Natural products; Reporter

Indexed keywords

AMPHOTERICIN B; DINACTIN; FLUCONAZOLE; GALACTOSE; IONOPHORE; MACROLIDE; MONACTIN; NONACTIN; PROTEIN HISTIDINE KINASE; TOLNAFTATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ANTIFUNGAL RESISTANCE; ARTICLE; ASPERGILLUS FUMIGATUS; BIOASSAY; BIOFILM; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDIASIS; CLAVISPORA LUSITANIAE; CONTROLLED STUDY; CRYPTOCOCCUS; CRYPTOCOCCUS GATTII; CRYPTOCOCCUS NEOFORMANS; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; FUNGAL STRAIN; ION TRANSPORT; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN EXPRESSION; RAT; SACCHAROMYCES CEREVISIAE; STREPTOMYCES;

EID: 84875187049     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693786.2012.710917     Document Type: Article

References (40)

1. Lockhart SL, Kiedema DJ, Pfaller MA. The epidemiology of fungal infections. In: Anaissie EJ, McGinnis MR, Pfaller MA (eds). Clinical Mycology. 2nd ed. Oxford, UK: Elsevier Inc ., 2009. pp. 1-14 .
2. Leroy O, Gangneux JP, Montravers P, et al. Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: A multicenter, prospective, observational study in France (2005-2006). Crit Care Med 2009 ; 37: 1612-1618 .
3. Stiller ET, Vandeputte J, Wachtel JL. Amphotericins A and B, antifungal antibiotics produced by a streptomycete. II. The isolation and properties of the crystalline amphotericins. Antibiot Annual 1955 ; 3: 587-591 .
4. Nyfeler R, Keller-Schierlein W. [Metabolites of microorganisms. 143. Echinocandin B, a novel polypeptide-antibiotic from Aspergillus nidulans var. echinulatus: Isolation and structural components]. Helv Chim Acta 1974 ; 57: 2459-2477. [in German].
5. Huang SX, Zhao LX, Tang SK, et al. E rythronolides H and I, new erythromycin congeners from a new halophilic actinomycete Actinopolyspora sp. YIM90600. Org Lett 2009 ; 11: 1353-1356 .
6. Huang SX, Powell E, Rajski SR, et al. Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from Actinopolymorpha rutilus. Org Lett 2010 ; 12: 3525-3527 .
7. Yu Z, Zhao LX, Jiang CL, et al. Bafi lomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209. J Antibiot (Tokyo) 2011 ; 64: 159-162 .
8. Huang SX, Yu Z, Robert F, et al. Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces spp. YIM56132 and YIM56141. J Antibiot (Tokyo) 2011 ; 64: 163-166 .
9. Zhao LX, Huang SX, Tang SK, et al. Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. J Nat Prod 2011; 74: 1990- 1995.
10. Clemons KV, Miller TK, Selitrennikoff CP, Stevens DA. fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis. Med Mycol 2002 ; 40: 259-262 .
11. Yamada-Okabe T, Mio T, Ono N, et al. Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans. J Bacteriol 1999 ; 181: 7243-7247 .
12. Bahn YS, Kojima K, Cox GM, Heitman J. A unique fungal twocomponent system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Mol Biol Cell 2006 ; 17: 3122-3135 .
13. Nemecek JC, Wuthrich M, Klein BS. Global control of dimorphism and virulence in fungi. Science 2006 ; 312: 583-588 .
14. Zizka Z. Biological effects of macrotetrolide antibiotics and nonactic acids. Folia Microbiol (Praha) 1998; 43: 7-14 .
15. Green S, Moehle C. Media and Culture of Yeast. In: Bonifacino JS DM, Harford JB, Lippincott Schwartz J, Yamada KM (eds). Current Protocols in Cell Biology. New York: John Wiley and Sons, Inc ., 2001. pp. 1.6.1-1.6.12 .
16. Krajaejun T, Wuthrich M, Gauthier GM, et al. Discordant infl uence of Blastomyces dermatitidis yeast-phase-specifi c gene BYS1 on morphogenesis and virulence. Infect Immun 2010 ; 78: 2522-2528 .
17. Grey M, Brendel M. A ten-minute protocol for transforming S accharomyces cerevisiae by electroporation. Curr Genet 1992 ; 22: 335-336 .
18. Motoyama T, Ohira T, Kadokura K, et al. An Os-1 family histidine kinase from a fi lamentous fungus confers fungicide-sensitivity to yeast. Curr Genet 2005 ; 47: 298-306 .
19. Wu Y, Sun YP. Synthesis of nonactin and the proposed structure of trilactone. Org Lett 2006 ; 8: 2831-2834 .
20. Nett J, Lincoln L, Marchillo K, et al. Putative role of beta-1,3 glucans in Candida albicans biofi lm resistance. Antimicrob Ag Chemother 2007; 51: 510-520 .
21. Hawser SP, Norris H, Jessup CJ, Ghannoum MA. Comparison of a 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino) carbonyl]-2H-t etrazolium hydroxide (XTT) colorimetric method with the standardized National Committee for Clinical Laboratory Standards method of testing clinical yeast isolates for susceptibility to antifungal agents. J Clin Microbiol 1998 ; 36: 1450-1452 .
22. van der Graaf CA, Netea MG, Verschueren I, van der Meer JW, Kullberg BJ. Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae. Infect Immun 2005 ; 73: 7458-7464 .
23. Andes D, Nett J, Oschel P, et al. Development and characterization of an in vivo central venous catheter Candida albicans biofi lm model. Infect Immun 2004 ; 72: 6023-6031 .
24. Haneda M, Nawata Y, Hayashi T, Ando K. Tetranactin, a new miticidal antibiotic. VI. Determination of dinactin, trinactin and tetranactin in their mixtures by NMR spectroscopy. J Antibio (Tokyo) 1974; 27: 555- 557.
25. Fleck WF, Ritzau M, Heinze S, Grafe U. Isolation of dimeric nonactic acid from the nonactin-producing Streptomyces spec JA 5909-1. J Basic Microb 1996; 36: 235-238 .
26. Smith LL. An additional source of macrotetrolide antibiotics. J Antibio (Tokyo) 1975; 28: 1000-1003 .
27. Laprade R, Grenier F, Page-Dansereau M, Dansereau J. Carriermediated ion transport in lipid bilayer membranes. Can J Biochem Cell Biol 1984 ; 62: 738-751 .
28. Pukkila-Worley R, Mylonakis E. Epidemiology and management of cryptococcal meningitis: Developments and challenges. Expert Opin Pharmacother 2008 ; 9: 551-560 .
29. Varma A, Kwon-Chung KJ. Heteroresistance of C ryptococcus gattii to fl uconazole. Antimicrob Ag Chemother 2010 ; 54: 2303-2311 .
30. Baillie GS, Douglas LJ. Role of dimorphism in the development of Candida albicans biofi lms. J Med Microbiol 1999 ; 48: 671-679 .
31. Bisson LF, Coons DM, Kruckeberg AL, Lewis DA. Yeast sugar transporters. Crit Rev Biochem Mol Biol 1993 ; 28: 259-308 .
32. Ando K, Oishi H, Hirano S, Okutomi T, Suzuki K. Tetranactin, a new miticidal antibiotic. I. Isolation, characterization and properties of tetranactin. J Antibio (Tokyo) 1971; 24: 347-352 .
33. Stefanac Z, Simon W. Ion Specifi c electrochemical behavior of macrotetrolides in membranes. Microchem J 1967 ; 12: 125-132 .
34. Alijo R, Ramos J. Several routes of activation of the potassium uptake system of yeast. Biochim Biophys Acta 1993 ; 1179: 224-228 .
35. Zygmunt WA. Intracellular loss of potassium in C andida albicans after exposure to polyene antifungal antibiotics. Appl Microbiol 1966 ; 14: 953-956 .
36. Hammond SM, Lambert PA, Kliger BN. The mode of action of polyene antibiotics; induced potassium leakage in Candida albicans. J Gen Microbiol 1974 ; 81: 325-330 .
37. Andes D, Forrest A, Lepak A, et al. I mpact of antimicrobial dosing regimen on evolution of drug resistance in vivo: Fl uconazole and Candida albicans. Antimicrob Ag Chemother 2006 ; 50: 2374-2383 .
38. Sanglard D, Kuchler K, Ischer F, et al. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specifi c multidrug transporters. Antimicrob Ag Chemother 1995 ; 39: 2378-2386 .
39. Prasad R, De Wergifosse P, Goffeau A, Balzi E. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr Gen 1995 ; 27: 320-329 .
40. Sullivan DJ, Moran GP, Pinjon E, et al. Comparison of the epidemiology, drug resistance mechanisms, and virulence of Candida dubliniensis and Candida albicans. FEMS Yeast Res 2004 ; 4: 369-376 .