Neural Stem Cells as a Therapeutic Approach for Amyotrophic Lateral Sclerosis

Molecular Therapy

Volumn 21, Issue 3, 2013, Pages 503-505

  Ferraiuolo, Laura ^a   Frakes, Ashley ^a,b   Kaspar, Brian K ^a,b,c  

^a THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; COPPER ZINC SUPEROXIDE DISMUTASE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR;

AMYOTROPHIC LATERAL SCLEROSIS; CELL SURVIVAL; CLINICAL EFFECTIVENESS; CLINICAL TRIAL (TOPIC); DISEASE COURSE; GENE; GENE MUTATION; GENE THERAPY; HUMAN; MOTONEURON; MOTOR PERFORMANCE; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; NOTE; OUTCOME ASSESSMENT; PATHOGENESIS; PATIENT SAFETY; PROTEIN SECRETION; SUPEROXIDE DISMUTASE 1 GENE; SURVIVAL TIME;

EID: 84875183161     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.24     Document Type: Note

References (12)

1. Altman, J and Das, GD (1965). Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 124: 319-335.
2. Teng, YD, Benn, SC, Kalkanis, SN, Shefner, JM, Onario, RC, Cheng, B et al. (2012). Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis. Sci Transl Med 4: 165ra164.
3. Al-Chalabi, A, Jones, A, Troakes, C, King, A, Al-Sarraj, S and van den Berg, LH (2012). The genetics and neuropathology of amyotrophic lateral sclerosis. Acta Neuropathol 124: 339-352.
4. Ilieva, H, Polymenidou, M and Cleveland, DW (2009). Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol 187: 761-772.
5. Xu, L, Yan, J, Chen, D, Welsh, AM, Hazel, T, Johe, K et al. (2006). Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats. Transplantation 82: 865-875.
6. Yan, J, Xu, L, Welsh, AM, Chen, D, Hazel, T, Johe, K et al. (2006). Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice. Stem Cells 24: 1976-1985.
7. Ravits, JM and La Spada, AR (2009). ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration. Neurology 73: 805-811.
8. Grad, LI, Guest, WC, Yanai, A, Pokrishevsky, E, O'Neill, MA, Gibbs, E et al. (2011). Intermolecular transmission of superoxide dismutase 1 misfolding in living cells. Proc Natl Acad Sci USA 108: 16398-16403.
9. Kaspar, BK (2008). Mesenchymal stem cells as trojan horses for GDNF delivery in ALS. Mol Ther 16: 1905-1906.
10. Suzuki, M, McHugh, J, Tork, C, Shelley, B, Klein, SM, Aebischer, P et al. (2007). GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. PLoS One 2: e689.
11. Suzuki, M, McHugh, J, Tork, C, Shelley, B, Hayes, A, Bellantuono, I et al. (2008). Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Mol Ther 16: 2002-2010.
12. Glass, JD, Boulis, NM, Johe, K, Rutkove, SB, Federici, T, Polak, M et al. (2012). Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients. Stem Cells 30: 1144-1151.