CD8 T cells and IFN-γ emerge as critical players for psoriasis in a novel model of mouse psoriasiform skin inflammation

Journal of Investigative Dermatology

Volumn 133, Issue 4, 2013, Pages 871-874

  Di Meglio, Paola ^a   Duarte, João H ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL PRODUCT; CHEMOKINE; DOXYCYCLINE; FENTOLIZUMAB; GAMMA INTERFERON; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; MESSENGER RNA; MONOCLONAL ANTIBODY; PROTEIN S 100; RAS PROTEIN; RECOMBINANT GAMMA INTERFERON; STAT3 PROTEIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG;

ACANTHOSIS; APOPTOSIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COMPARTMENTALIZATION; CELL CYCLE PROGRESSION; CELL INFILTRATION; CLINICAL FEATURE; CYTOKINE PRODUCTION; DENDRITIC CELL; DERMATITIS; DRUG EFFICACY; EFFECTOR CELL; EPIDERMIS; GENE DELETION; GENE OVEREXPRESSION; GENETIC DIFFERENCE; GENETIC MANIPULATION; HISTOPATHOLOGY; HUMAN; IMMUNOPATHOGENESIS; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MEDIATOR; MOUSE; NONHUMAN; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PSORIASIS; REVIEW; RISK FACTOR; SKIN; SKIN DEFECT; TH1 CELL;

EID: 84875175520     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.426     Document Type: Note

References (25)

1. Austin LM, Ozawa M, Kikuchi T et al. (1999) The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol 113:752-9
2. Baker BS, Powles AV, Valdimarsson H et al. (1988) An altered response by psoriatic keratinocytes to gamma interferon. Scand J Immunol 28:735-40
3. Bowcock AM, Shannon W, Du F et al. (2001) Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genet 10:1793-805
4. Boyman O, Hefti HP, Conrad C et al. (2004) Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factoralpha. J Exp Med 199:731-6
5. Cai Y, Shen X, Ding C et al. (2011) Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation. Immunity 35:596-610
6. Capon F, Burden AD, Trembath RC et al. (2012) Psoriasis and other complex trait dermatoses: from Loci to functional pathways. J Invest Dermatol 132:915-22
7. Conrad C, Boyman O, Tonel G et al. (2007) Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med 13:836-42
8. Di Cesare A, Di Meglio P, Nestle FO (2009) The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 129:1339-50
9. Di Meglio P, Perera GK, Nestle FO (2011) The multitasking organ: recent insights into skin immune function. Immunity 35:857-869
10. Fernandez-Medarde A, Santos E (2011) Ras in cancer and developmental diseases. Genes Cancer 2:344-58
11. Fierlbeck G, Rassner G, Muller C (1990) Psoriasis induced at the injection site of recombinant interferon gamma. Results of immunohistologic investigations. Arch Dermatol 126:351-5
12. Gudjonsson JE, Johnston A, Dyson M et al. (2007) Mouse models of psoriasis. J Invest Dermatol 127:1292-308
13. Gunderson A, Mohammed J, Horvath F et al. (2013) CD8 T cells mediate RAS-induced Psoriasis-like skin inflammation through IFN-g. J Invest Dermatol 133:955-63
14. Gunther C, Carballido-Perrig N, Kaesler S et al. (2012) CXCL16 and CXCR6 are upregulated in psoriasis and mediate cutaneous recruitment of human CD8 T cells. J Invest Dermatol 132:626-34
15. Hammar H, Gu SQ, Johannesson A et al. (1984) Subpopulations of mononuclear cells in microscopic lesions of psoriatic patients. Selective accumulation of suppressor/cytotoxic T cells in epidermis during the evolution of the lesion. J Invest Dermatol 83:416-20
16. Hirota K, Duarte JH, Veldhoen M et al. (2011) Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12:255-63
17. HogenEsch H, Gijbels MJ, Offerman E et al. (1993) A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice. Am J Pathol 143:972-82
18. Johnson-Huang LM, Suarez-Farinas M, Pierson KC et al. (2012) A single intradermal injection of IFN-gamma induces an inflammatory state in both non-lesional psoriatic and healthy skin. J Invest Dermatol 132:1177-87
19. Kryczek I, Bruce AT, Gudjonsson JE et al. (2008) Induction of IL-17 T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol 181:4733-41
20. Lin P, Baldassare JJ, Voorhees JJ et al. (1999) Increased activation of Ras in psoriatic lesions. Skin Pharmacol Appl Skin Physiol 12:90-7
21. Lowes MA, Kikuchi T, Fuentes-Duculan J et al. (2008) Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 128:1207-11
22. Ortega C, Fernandez AS, Carrillo JM et al. (2009) IL-17- producing CD8 T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. J Leukoc Biol 86:435-43
23. Reinisch W, de Villiers W, Bene L et al. (2010) Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study. Inflamm Bowel Dis 16:233-42
24. Skurkovich B, Skurkovich S (2003) Anti-interferongamma antibodies in the treatment of autoimmune diseases. Curr Opin Mol Ther 5:52-7
25. van der Fits L, Mourits S, Voerman JS et al. (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol 182:5836-45