Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells

Journal of Cellular Biochemistry

Volumn 114, Issue 5, 2013, Pages 1050-1057

  Padmanabhan, Achuth ^a   Gosc, Eliza B ^a   Bieberich, Charles J ^a,b  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

NKX3.1; phosphorylation; Pim 1 kinase; prostate cancer

Indexed keywords

LYSINE; MESSENGER RNA; PROSTATE SPECIFIC TUMOR SUPPRESSOR NKX3.1; PROTEASOME; PROTEIN KINASE PIM 1; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; EPITHELIUM CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MASS SPECTROMETRY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

CELL LINE, TUMOR; DNA MUTATIONAL ANALYSIS; HALF-LIFE; HOMEODOMAIN PROTEINS; HUMANS; LYSINE; MALE; MODELS, BIOLOGICAL; MUTANT PROTEINS; ORGAN SPECIFICITY; PHOSPHORYLATION; PROSTATE; PROSTATIC NEOPLASMS; PROTEIN BIOSYNTHESIS; PROTEIN KINASE INHIBITORS; PROTEIN STABILITY; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-PIM-1; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84875165198     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24444     Document Type: Article

References (13)

1. Abdulkadir SA, Magee JA, Peters TJ, Kaleem Z, Naughton CK, Humphrey PA, Milbrandt J,. 2002. Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol 22 (5): 1495-1503.
2. Bethel CR, Bieberich CJ,. 2007. Loss of NKX3.1 expression in the transgenic adenocarcinoma of mouse prostate model. Prostate 67 (16): 1740-1750.
3. Bethel CR, Faith D, Li X, Guan B, Hicks JL, Lan F, Jenkins RB, Bieberich CJ, De Marzo AM,. 2006. Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: Association with gleason score and chromosome 8p deletion. Cancer Res 66 (22): 10683-10690.
4. Bhatia-Gaur R, Donjacour AA, Sciavolino PJ, Kim M, Desai N, Young P, Norton CR, Gridley T, Cardiff RD, Cunha GR, Abate-Shen C, Shen MM,. 1999. Roles for NKX3.1 in prostate development and cancer. Genes Dev 13 (8): 966-977.
5. Bieberich CJ, Fujita K, He WW, Jay G,. 1996. Prostate-specific and androgen-dependent expression of a novel homeobox gene. J Biol Chem 271 (50): 31779-31782.
6. Guan B, Pungaliya P, Li X, Uquillas C, Mutton LN, Rubin EH, Bieberich CJ,. 2008. Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1. J Biol Chem 283 (8): 4834-4840.
7. He WW, Sciavolino PJ, Wing J, Augustus M, Hudson P, Meissner PS, Curtis RT, Shell BK, Bostwick DG, Tindall DJ, Gelmann EP, Abate-Shen C, Carter KC,. 1997. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. Genomics 43 (1): 69-77.
8. Kim MJ, Bhatia-Gaur R, Banach-Petrosky WA, Desai N, Wang Y, Hayward SW, Cunha GR, Cardiff RD, Shen MM, Abate-Shen C,. 2002. Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res 62 (11): 2999-3004.
9. Li X, Guan B, Maghami S, Bieberich CJ,. 2006. NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells. Mol Cell Biol 26 (8): 3008-3017.
10. Li X, Guan B, Srivastava MK, Padmanabhan A, Hampton BS, Bieberich CJ,. 2007. The reverse in-gel kinase assay to profile physiological kinase substrates. Nat Methods 4 (11): 957-962.
11. Magee JA, Abdulkadir SA, Milbrandt J,. 2003. Haploinsufficiency at the NKX3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation. Cancer Cell 3 (3): 273-283.
12. Markowski MC, Bowen C, Gelmann EP,. 2008. Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1. Cancer Res 68 (17): 6896-6901.
13. Wang J, Anderson PD, Luo W, Gius D, Roh M, Abdulkadir SA,. 2012. Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells. Oncogene 31 (14): 1794-1803.