Escherichia coli β-galactosidase inhibitors through modifications at the aglyconic moiety: Experimental evidence of conformational distortion in the molecular recognition process

Chemistry - A European Journal

Volumn 19, Issue 13, 2013, Pages 4262-4270

  Calle, Luis ^a   Roldós, Virginia ^a   Cañada, F Javier ^a   Uhrig, María Laura ^b   Cagnoni, Alejandro J ^b   Manzano, Verónica E ^b   Varela, Oscar ^b   Jiménez Barbero, Jesus ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

conformation analysis; enzyme models; glycosides; NMR spectroscopy; S ligands

Indexed keywords

CONFORMATION ANALYSIS; CONFORMATIONAL SELECTION; ENZYME MODELS; EXPERIMENTAL EVIDENCE; GLYCOSIDASE INHIBITORS; GROUND-STATE CONFORMATIONS; MOLECULAR MODELING TECHNIQUES; S LIGANDS;

CHEMICAL COMPOUNDS; ESCHERICHIA COLI; GLYCOSIDES; LIGANDS; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; VAN DER WAALS FORCES;

CONFORMATIONS;

BENZYL 3 DEOXY 4 S (BETA D GALACTOPYRANOSYL) 4 THIO BETA D ERYTHRO PENTOPYRANOSIDE; BENZYL 3 DEOXY 4 S (BETA D GALACTOPYRANOSYL) 4 THIO BETA D THREO PENTOPYRANOSIDE; BENZYL-3-DEOXY-4-S-(BETA-D-GALACTOPYRANOSYL)-4-THIO-BETA-D-ERYTHRO-PENTOPYRANOSIDE; BENZYL-3-DEOXY-4-S-(BETA-D-GALACTOPYRANOSYL)-4-THIO-BETA-D-THREO-PENTOPYRANOSIDE; BETA GALACTOSIDASE; DISACCHARIDE; LIGAND; THIOGLYCOSIDE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; ESCHERICHIA COLI; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

BETA-GALACTOSIDASE; DISACCHARIDES; ESCHERICHIA COLI; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; THIOGLUCOSIDES;

EID: 84875164302     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201203673     Document Type: Article

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