Approach to inappropriate sexual behaviour in people with dementia;Approche pour les comportements sexuels inappropriés chez des personnes atteintes de démence

Canadian Family Physician

Volumn 59, Issue 3, 2013, Pages

  Joller, Petra ^a   Gupta, Neeraj ^a   Seitz, Dallas P ^a   Frank, Christopher ^a   Gibson, Michelle ^a   Gill, Sudeep S ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; CIMETIDINE; CITALOPRAM; CLOMIPRAMINE; CONJUGATED ESTROGEN; CYPROTERONE ACETATE; DIETHYLSTILBESTROL; DONEPEZIL; ESTROGEN; FINASTERIDE; GABAPENTIN; HALOPERIDOL; LEUPRORELIN; MEDROXYPROGESTERONE ACETATE; MIRTAZAPINE; PAROXETINE; PINDOLOL; PROPRANOLOL; QUETIAPINE; RIVASTIGMINE; TRAZODONE;

ADRENAL INSUFFICIENCY; AGRANULOCYTOSIS; ATAXIA; BEHAVIOR DISORDER; BONE MARROW SUPPRESSION; BONE PAIN; BRADYCARDIA; BRONCHOSPASM; COGNITIVE DEFECT; CONSTIPATION; CULTURAL FACTOR; DEMENTIA; DEPRESSION; DIABETES MELLITUS; DIZZINESS; EXTRAPYRAMIDAL SYMPTOM; FAINTNESS; FALLING; FATIGUE; GALACTORRHEA; GLUCOSE BLOOD LEVEL; GYNECOMASTIA; HEART VENTRICLE ARRHYTHMIA; HOT FLUSH; HUMAN; HYPERSEXUALITY; HYPONATREMIA; HYPOPHYSIS APOPLEXY; HYPOTENSION; INAPPROPRIATE SEXUAL BEHAVIOR; INSOMNIA; LIVER TOXICITY; MEDICOLEGAL ASPECT; NAUSEA; ORTHOSTATIC HYPOTENSION; OSTEOPOROSIS; PRIAPISM; PSYCHOPHARMACOTHERAPY; RELIGION; REVIEW; SCROTAL PAIN; SEDATION; SIDE EFFECT; SOCIAL BELIEF; STEVENS JOHNSON SYNDROME; SYSTEMATIC REVIEW; TREATMENT OUTCOME; TREMOR; URINE INCONTINENCE; URINE RETENTION; VENOUS THROMBOEMBOLISM; WEIGHT GAIN;

AGED; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; BEHAVIOR CONTROL; DEMENTIA; FAMILY PRACTICE; HEALTH SERVICES FOR THE AGED; HORMONE REPLACEMENT THERAPY; HUMANS; SEXUAL BEHAVIOR;

EID: 84875161009     PISSN: 0008350X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (47)

1. McKeith I, Cummings J. Behavioural changes and psychological symptoms in dementia disorders. Lancet Neurol 2005;4(11):735-42.
2. Kapusta P, Regier L, Bareham J, Jensen B. Behaviour management in dementia. Can Fam Physician 2011;57:1420-2.
3. Wright LK. Affection and sexuality in the presence of Alzheimer's disease: a longitudinal study. Sex Disabil 1998;16(3):167-79.
4. Higgins A, Barker P, Begley CM. Hypersexuality and dementia: dealing with inappropriate sexual expression. Br J Nurs 2004;13(22):1330-4.
5. Kuhn DR, Greiner D, Arseneau L. Addressing hypersexuality in Alzheimer's disease. J Gerontol Nurs 1998;24(4):44-50.
6. Hajjar RR, Kamel HK. Sex and the nursing home. Clin Geriatr Med 2003;19(3):575- 86.
7. Hajjar RR, Kamel HK. Sexuality in the nursing home, part 1: attitudes and barriers to sexual expression. J Am Med Dir Assoc 2004;5(2 Suppl):S42-7.
8. Kamel HK, Hajjar RR. Sexuality in the nursing home, part 2: managing abnormal behavior - legal and ethical issues. J Am Med Dir Assoc 2004;5(2 Suppl):S48-52.
9. Bardell A, Lau T, Fedoroff JP. Inappropriate sexual behavior in a geriatric population. Int Psychogeriatr 2011;23(7):1182-8. Epub 2011 Apr 19.
10. Series H, Dégano P. Hypersexuality in dementia. Adv Psychiatr Treat 2005;11(6):424-31.
11. Johnson C, Knight C, Alderman N. Challenges associated with the definition and assessment of inappropriate sexual behaviour amongst individuals with an acquired neurological impairment. Brain Inj 2006;20(7):687-93.
12. Knight C, Alderman N, Johnson C, Green S, Birkett-Swan L, Yorstan G. The St Andrew's Sexual Behaviour Assessment (SASBA): development of a standardised recording instrument for the measurement and assessment of challenging sexual behaviour in people with progressive and acquired neurological impairment. Neuropsychol Rehabil 2008;18(2):129-59.
13. St Andrew's Healthcare [website]. St Andrew's Sexual Behaviour Assessment. Northampton, UK: St Andrew's Healthcare; 2008. Available from: www.stah.org/services/brain-injury/sasba.aspx. Accessed 2012 Jun 1.
14. Tucker I. Management of inappropriate sexual behaviors in dementia: a literature review. Int Psychogeriatr 2010;22(5):683-92. Epub 2010 Mar 15.
15. Lothstein LM, Fogg-Waberski J, Reynolds P. Risk management and treatment of sexual disinhibition in geriatric patients. Conn Med 1997;61(9):609-18.
16. Bird M, Jones RH, Korten A, Smithers H. A controlled trial of a predominantly psychosocial approach to BPSD: treating causality. Int Psychogeriatr 2007;19(5):874-91. Epub 2007 Jan 19.
17. Tune LE, Rosenberg J. Nonpharmacological treatment of inappropriate sexual behavior in dementia: the case of the pink panther. Am J Geriatr Psychiatry 2008;16(7):612-3.
18. Guay DR. Inappropriate sexual behaviors in cognitively impaired older individuals. Am J Geriatr Pharmacother 2008;6(5):269-88.
19. Stewart JT, Shin KJ. Paroxetine treatment of sexual disinhibition in dementia [Letter]. Am J Psychiatry 1997;154(10):1474.
20. Raji M, Liu D, Wallace D. Case report: sexual aggressiveness in a patient with dementia: sustained clinical response to citalopram. Ann Longterm Care 2000;8:81-3.
21. Chen ST. Treatment of a patient with dementia and inappropriate sexual behaviors with citalopram. Alzheimer Dis Assoc Disord 2010;24(4):402-3.
22. Leo RJ, Kim KY. Clomipramine treatment of paraphilias in elderly demented patients. J Geriatr Psychiatry Neurol 1995;8(2):123-4.
23. Simpson DM, Foster D. Improvement in organically disturbed behavior with trazodone treatment. J Clin Psychiatry 1986;47(4):191-3.
24. Cooper AJ. Medroxyprogesterone acetate (MPA) treatment of sexual acting out in men suffering from dementia. J Clin Psychiatry 1987;48(9):368-70.
25. Weiner MF, Denke M, Williams K, Guzman R. Intramuscular medroxyprogesterone acetate for sexual aggression in elderly men. Lancet 1992;339(8801):1121-2.
26. Amadeo M. Antiandrogen treatment of aggressivity in men suffering from dementia. J Geriatr Psychiatry Neurol 1996;9(3):142-5.
27. Light SA, Holroyd S. The use of medroxyprogesterone acetate for the treatment of sexually inappropriate behaviour in patients with dementia. J Psychiatry Neurosci 2006;31(2):132-4.
28. Haussermann P, Goecker D, Beier K, Schroeder S. Low-dose cyproterone acetate treatment of sexual acting out in men with dementia. Int Psychogeriatr 2003;15(2):181-6.
29. Na HR, Lee JW, Park SM, Ko SB, Kim S, Cho ST. Inappropriate sexual behaviors in patients with vascular dementia: possible response to finasteride. J Am Geriatr Soc 2009;57(11):2161-2.
30. Kyomen HH, Nobel KW, Wei JY. The use of estrogen to decrease aggressive physical behavior in elderly men with dementia. J Am Geriatr Soc 1991;39(11):1110-2.
31. Ott BR. Leuprolide treatment of sexual aggression in a patient with dementia and the Klüver-Bucy syndrome. Clin Neuropharmacol 1995;18(5):443-7.
32. Schneider LS, Dagerman K, Insel PS. Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. Am J Geriatr Psychiatry 2006;14(3):191-210.
33. Kobayashi T. Effect of haloperidol on a patient with hypersexuality following frontal lobe injury. Psychogeriatrics 2004;4(2):49-52.
34. MacKnight C, Rojas-Fernandez C. Quetiapine for sexually inappropriate behavior in dementia. J Am Geriatr Soc 2000;48(6):707.
35. Prakash R, Pathak A, Munda S, Bagati D. Quetiapine effective in treatment of inappropriate sexual behavior of Lewy body disease with predominant frontal lobe signs. Am J Alzheimers Dis Other Demen 2009;24(2):136-40. Epub 2009 Jan 7.
36. Sheldon LJ, Ancill RJ, Holliday SG. Gabapentin in geriatric psychiatry patients. Can J Psychiatry 1998;43(4):422-3.
37. Alkhalil C, Hahar N, Alkhalil B, Zavros G, Lowenthal DT. Can gabapentin be a safe alternative to hormonal therapy in the treatment of inappropriate sexual behavior in demented patients? Int Urol Nephrol 2003;35(2):299-302.
38. Alkhalil C, Tanvir F, Alkhalil B, Lowenthal DT. Treatment of sexual disinhibition in dementia: case reports and review of the literature. Am J Ther 2004;11(3):231-5.
39. Steinman MA, Bero LA, Chren MM, Landefeld CS. Narrative review: the promotion of gabapentin: an analysis of internal industry documents. Ann Intern Med 2006;145(4):284-93.
40. Löfgren E, Tapanainen JS, Koivunen R, Pakarinen A, Isojärvi JI. Effects of carbamazepine and oxcarbazepine on the reproductive endocrine function in women with epilepsy. Epilepsia 2006;47(9):1441-6.
41. Freymann N, Michael R, Dodel R, Jessen F. Successful treatment of sexual disinhibition in dementia with carbamazepine - a case report. Pharmacopsychiatry 2005;38(3):144-5.
42. Poetter CE, Stewart JT. Treatment of indiscriminate, inappropriate sexual behavior in frontotemporal dementia with carbamazepine. J Clin Psychopharmacol 2012;32(1):137-8.
43. Alagiakrishnan K, Sclater A, Robertson D. Role of cholinesterase inhibitor in the management of sexual aggression in an elderly demented woman. J Am Geriatr Soc 2003;51(9):1326.
44. Chemali Z. Donepezil and hypersexuality: a report of two cases. Prim Psychiatry 2003;10(7):78-9.
45. Lo Coco D, Cannizzaro E. Inappropriate sexual behaviors associated with donepezil treatment: a case report. J Clin Psychopharmacol 2010;30(2):221-2.
46. Wiseman SV, McAuley JW, Freidenberg GR, Freidenberg DL. Hypersexuality in patients with dementia: possible response to cimetidine. Neurology 2000;54(10):2024.
47. Jensen CF. Hypersexual agitation in Alzheimer's disease. J Am Geriatr Soc 1989;37(9):917.