Can gabapentin be a safe alternative to hormonal therapy in the treatment of inappropriate sexual behavior in demented patients?

International Urology and Nephrology

Volumn 35, Issue 2, 2003, Pages 299-302

  Alkhalil, Chadi ^a   Hahar, Nillay ^a   Alkhalil, Bachar ^a   Zavros, George ^a   Lowenthal, David T ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE RECEPTOR AFFECTING AGENT; GABAPENTIN; QUETIAPINE;

AGED; AGGRESSION; AGITATION; ALZHEIMER DISEASE; ARTICLE; BEHAVIOR DISORDER; BLOOD CLOTTING DISORDER; BLOOD PRESSURE REGULATION; BREAST CANCER; CASE REPORT; DEMENTIA; DEPRESSION; DIABETES MELLITUS; DIZZINESS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG EXCRETION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG SAFETY; ERECTILE DYSFUNCTION; EXHIBITIONISM; FATIGUE; FLUID RETENTION; GYNECOMASTIA; HOT FLUSH; HUMAN; HYPERTENSION; IMPOTENCE; INJECTION SITE REACTION; LEG CRAMP; LIBIDO DISORDER; MALE; MASTURBATION; NAUSEA AND VOMITING; NURSING HOME; SEXUAL BEHAVIOR; SIDE EFFECT; SOMNOLENCE; TREATMENT FAILURE; TREMOR; WEIGHT GAIN;

ACETIC ACIDS; AGED; ALZHEIMER DISEASE; AMINES; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; HORMONES; HUMANS; MALE; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL;

EID: 1842537089     PISSN: 03011623     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:UROL.0000020338.21912.c2     Document Type: Article

References (21)

1. Ryden M, Bossenmaier M, McLachlan C. Aggressive behavior in cognitively impaired nursing home residents. Res Nurs Health 1991; 14: 87-95.
2. Tinetti M, Liu W, Marottoli R, Ginter S. Mechanical restraint use among residents of skilled nursing facilities: prevalence, patterns, and predictors. JAMA 1991; 265: 468-471.
3. Burgio L, Butler F, Engel B. Nurses' attitudes towards geriatric behavior problems in long-term care settings. Clin Gerontol 1988; 7: 23-34.
4. Ott BR, Lapane KL, Gambassi G. Gender differences in the treatment of behavior problems in Alzheimer's disease. Neurology 2000; 54(2): 427-432.
5. Kumar A, Koss E, Metzler D, Moore A, Friedland RP. Behavioral symptomatology in dementia of the Alzheimer type. Alzheimer Dis Assoc Disord 1988; 2(4): 363-365.
6. Mendez MF, Chow T, Ringman J, Twitchell G, Hinkin CH. Pedophilia and temporal lobe disturbances. J Neuropsychiatry Clin Neurosci 2000; 12(1): 71-76.
7. Dauvilliers Y, Mayer G, Lecendreux M, Neidhart E, Peraita-Adrados R, Sonka K, Billiard M, Tafti M. Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analyses. Neurology 10 Dec 2002; 59(11): 1739-1745.
8. Pearson HJ. Paraphilias, impulse control, and serotonin (letter). J Clin Psychopharmacol 1990; 10: 233.
9. Leo RJ, Kim KY. Clomipramine treatment of paraphilias in elderly demented patients. J Geriatr Psychiatry Neurol 1995; 8: 123-124.
10. Bell S. Reduced testosterone level in a venlafaxine treated patient. Ann Clin Psychiatry 1 Sep 2000; 12(3): 171-173.
11. Bruni J. Gabapentin. Can J Neurol Sci 1996; 23 (Suppl 2): S10-12.
12. Semanchuk MR, Labiner DM. Gabapentin and lamotrigine: prescribing guidelines for psychiatry. J Pract Psychiatry Behav Health 1997; 3: 334-342.
13. Palmer AM, Stratmann GC, Procter AW, Brown DM. Possible neurotransmitter basis of behavioral changes in Alzheimer's disease. Ann Neurol 1988; 23: 616-620.
14. Hardy J, Cowburn R, Barton A, Reynolds G, Dodd P, Wester P et al. A disorder of cortical GABAergic innervation in Alzheimer's disease. Neurosci Lett 1987; 73: 192-196.
15. Regan W, Gordon S. Gabapentin for behavioral agitation in Alzheimer's disease (letter). J Clin Pharmachol 1997; 17: 59-60.
16. Dallocchio C, Buffa C, Mazzarello P. Combination of donepezil and gabapentin for behavioral disorder in Alzheimer's disease (letter). J Clin Psychiatry 2000; 61: 64.
17. Sheldon LJ, Ancill RJ, Holliday SG. Gabapentin in geriatric psychiatry patients. Can J Psychiatry 1998; 43: 422-423.
18. Goldenberg G, Kahaner K, Basavaraju N, Rangu S. Gabapentin for disruptive behavior in an elderly demented patient. Drugs Aging 1998; 13: 183-184.
19. Low RA Jr, Brandes M. Gabapentin for the management of agitation (letter). J Clin Psychopharmacol 1999; 19, 482-483.
20. Hermann N, Lanctot K, Myszak M. Effectiveness of gabapentin for the treatment of behavioral disorders in dementia. J Clin Psychopharmacol 2000; 20: 90-93.
21. Roane DM, Feinberg TE, Meckler L, Miner CR, Scicutella A, Rosenthal RN. Treatment of dementia-associated agitation with gabapentin. J Neuropsychiatry Clin Neurosci 2000; 12: 40-43.