Gentamicin pharmacokinetics in neonates undergoing therapeutic hypothermia

Therapeutic Drug Monitoring

Volumn 35, Issue 2, 2013, Pages 217-222

  Mark, Liana F ^a   Solomon, Addishiwot ^b   Northington, Frances J ^c   Lee, Carlton K K ^b,d  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b Shady Grove Adventist Hospital   (United States)

^c Department of Pediatrics ^*  (United States)

^d JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

aminoglycoside; cooling; hypoxic ischemic encephalopathy

Indexed keywords

GENTAMICIN;

ARTICLE; BLOOD LEVEL; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; MALE; NEWBORN; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

ANTI-BACTERIAL AGENTS; CASE-CONTROL STUDIES; FEMALE; GENTAMICINS; HUMANS; HYPOTHERMIA, INDUCED; INFANT, NEWBORN; MALE; RETROSPECTIVE STUDIES;

EID: 84875158199     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e3182834335     Document Type: Article

References (11)

1. Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Human Dev. 2010; 86: 329-338.
2. Jacobs SE, Hunt R, Tarnow-Mordi WO, et al. Cooling for newborns with hypoxic ischaemic encephalopathy [review]. Cochrane Database Syst Rev. 2008; (4): 2-3.
3. Guignard JP, Gillieron P. Effect of modest hypothermia on the immature kidney. Acta Paediatr. 1997; 86: 1040-1041.
4. Van den Broek MPH, Groenendaal F, Egberts ACG, et al. Effects of hypothermia on pharmacokinetics and pharmacodynamics. Clin Pharmacokin. 2010; 49: 277-294.
5. Liu X, Borooah M, Stone J, et al. Serum gentamicin concentrations in encephalopathic infants are not affected by therapeutic hypothermia. Pediatrics. 2009; 124: 310-315.
6. Young T, Mangum B, Thomson Reuters Editorial Staff. NeoFax. Montvale, NJ: Thomson Reuters, Inc; 2008.
7. CEDIA Gentamicin II[package insert].Indianapolis, IN: Roche Diagnostics; 2010.
8. Murphy JE. General pharmacokinetic principles. In: Murphy JE, ed. Clinical Pharmacokinetics. Bethesda, MD: American Society of Health-System Pharmacists; 2008: xxxvii-xxxix.
9. Meng L, Frymoyer A, Verotta D, et al. Gentamicin Clearance is Decreased in Neonates With Hypoxic Ischemic Encephalopathy: Proceedings of the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA; September, 2010.
10. Satas S, Hoem NO, Melby N, et al. Influence of mild hypothermia after hypoxia-ischemia on the pharmacokinetics of gentamicin in newborn pigs. Biol Neonate. 2000; 77: 50-57.
11. Koren G, Barker C, Bohn D, et al. Influence of hypothermia on the pharmacokinetics of gentamicin and theophylline in piglets. Crit Care Med. 1985; 13: 844-847.