Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition

American Journal of Pathology

Volumn 182, Issue 4, 2013, Pages 1400-1411

  Smith, Kathleen B ^a   Tran, Linh M ^a   Tam, Brenna M ^a   Shurell, Elizabeth M ^a   Li, Yunfeng ^a   Braas, Daniel ^a   Tap, William D ^a   Christofk, Heather R ^a   Dry, Sarah M ^a   Eilber, Fritz C ^a   Wu, Hong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAPAMYCIN; SORAFENIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE SPECIFIC SURVIVAL; DOWN REGULATION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIPOSARCOMA; MALE; MOUSE; NONHUMAN; PATIENT CARE; PHENOTYPE; PRIORITY JOURNAL; REPRODUCIBILITY; TUMOR XENOGRAFT;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPID METABOLISM; LIPOSARCOMA; MALE; MICE; MIDDLE AGED; NEOPLASM INVASIVENESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84875155842     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.01.002     Document Type: Article

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