Porous microsphere and its applications

International Journal of Nanomedicine

Volumn 8, Issue , 2013, Pages 1111-1120

  Cai, Yunpeng ^a,b   Chen, Yinghui ^c   Hong, Xiaoyun ^b   Liu, Zhenguo ^a   Yuan, Weien ^b  

^a XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Pore; Porogen; Porosity; Pulmonary drug delivery; Seed swelling; Suspension polymerization; Tissue regeneration

Indexed keywords

DRUG CARRIER; HUMAN GROWTH HORMONE; MICROSPHERE; POROUS MICROSPHERE; UNCLASSIFIED DRUG;

ABSORPTION; CONTROLLED RELEASE FORMULATION; DESORPTION; DRUG DELIVERY SYSTEM; HUMAN; LUNG; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; RESEARCH; REVIEW; SURFACE PROPERTY; SYNTHESIS; TISSUE REGENERATION;

PORE; POROGEN; POROSITY; PULMONARY DRUG DELIVERY; SEED SWELLING; SUSPENSION POLYMERIZATION; TISSUE REGENERATION;

ANIMALS; DRUG CARRIERS; HUMANS; MICROSPHERES; PARTICLE SIZE; POLYMERIZATION; POROSITY;

EID: 84875143961     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S41271     Document Type: Review

References (68)

1. Cui YN, Li RL, Deng W, Kan CY. Advances in porous polymer particles. Polymer Materials Science and Engineering. 2008;24(8):1-8.
2. Crotts G, Park TG. Preparation of porous and nonporous biodegradable polymeric hollow microspheres. J Control Release. 1995; 35(2-3):91-105.
3. Zdravkov B, Cermák JJ, Janku J, Kucerová V, Šefara M. Pore classif-cation in the characterization of porous materials. Central European Journal of Chemistry. 2007;5(2):385-395.
4. Gao SL, Wang YJ, Diao X, Luo G, Dai Y. Effect of pore diameter and cross-linking method on the immobilization effciency of Candida rugosa lipase in SBA-15. Bioresour Technol. 2010;101(11):3830-3837.
5. Cheng XK, He QJ, Li JQ, Huang Z, Chi R. Control of pore size of the bubble-template porous carbonated hydroxyapatite microsphere by adjustable pressure. Cryst Growth Des. 2009;9(6):2770-2775.
6. Li J, Zhang Y. Porous polymer flms with size-tunable surface pores. Chem Mater. 2007;19(10):2581-2584.
7. Cao SS, Zhao ZY, Jin X, et al. Unique double-shelled hollow silica microspheres: template-guided self-assembly, tunable pore size, high thermal stability, and their application in removal of neutral red. J Mater Chem. 2011;21:19124-19131.
8. Si TB, Wang YX, Wei W, Lv P, Ma G, Su Z. Effect of acrylic acid weight percentage on the pore size in poly(N-Isopropyl acrylamide-co-acrylic acid) microspheres. React Funct Polym. 2011;71(7):728-735.
9. Yoshizawa H, Maruta M, Ikeda S, Hatate Y, Kitamura Y. Preparation and pore-size control of hydrophilic monodispersed polymer microspheres for size-exclusive separation of biomolecules by the SPG membrane emulsifcation technique. Colloid Polym Sci. 2004; 282(9):965-971.
10. Draghi L, Resta S, Pirozzolo MG, Tanzi MC. Microspheres leaching for scaffold porosity control. J Mater Sci Mater Med. 2005; 16(12):1093-1097.
11. Peng CY, Zhao QH, Gao CY. Sustained delivery of doxorubicin by porous CaCO3 and chitosan/alginate multilayers-coated CaCO3 microparticles. Colloids Surf A Physicochem Eng Asp. 2010;353(2-3): 132-139.
12. Li ZH, Jia Z, Luan YX, Mu TC. Ionic liquids for synthesis of inorganic nanomaterials. Curr Opin Solid State Mater Sci. 2008;12(1):1-8.
13. Wu C, Wang Z, Zhi Z, Jiang T, Zhang J, Wang S. Development of biodegradable porous starch foam for improving oral delivery of poorly water soluble drugs. Int J Pharm. 2011;403(1-2):162-169.
14. Duncanson WJ, Zieringer M, Wagner O, et al. Microfuidic synthesis of monodispersed porous microspheres with size-tunable pores. Soft Matter. 2012;8:10636-10640.
15. Yang Y, Bajaj N, Xu P, Ohn K, Tsifansky MD, Ye o Y. Development of highly porous large PLGA microparticles for pulmonary drug delivery. Biomaterials. 2009;30(10):1947-1953.
16. Lin HR, Kuo CJ, Yang CY, Shaw SY, Wu YJ. Preparation of macropo-rous biodegradable PLGA scaffolds for cell attachment with the use of mixed salts as porogen additives. J Biomed Mater Res. 2002; 63(3):271-279.
17. Arnold MM, Gorman EM, Schieber LJ, Munson EJ, Berkland C. NanoCipro encapsulation in monodispersed large porous PLGA microparticles. J Control Release. 2007;121(1-2):100-109.
18. Li J, Chen Y, Mak A F, Tuan RS, Li L, Li Y. A one-step method to fabricate PLLA scaffolds with deposition of bioactive hydroxy-apatite and collagen using ice-based microporogens. Acta Biomater. 2010;6(6):2013-2019.
19. Ma Z, Gao C, Gong Y, Shen J. Paraffn spheres as porogen to fabricate poly(L-lactic acid) scaffolds with improved cytocompatibility for cartilage tissue engineering. J Biomed Mater Res B Appl Biomater. 2003;67(1):610-617.
20. Liu QQ, Wang L, Xiao AG. Research progress in macroporous styrene-divinylbenzene co-polymer microspheres. Designed Monomers and Polymers. 2007;10(5):405-423.
21. Takai C, Hotta T, Shiozaki S, Matsumoto S, Fukui T. Key techniques to control porous microsphere morphology in S/O/W emulsion system. Colloids Surf A Physicochem Eng Asp. 2011;373(1-3):152-157.
22. Takai C, Hotta T, Shiozaki S, Boonsongrit Y, Abe H. Unique porous micro-spheres with dense core and a porous layer prepared by a novel S/O/W emulsion technique. Chem Commun (Camb). 2009;(37):5533-5535.
23. Sullivan A P, Kilpatrick PK. The effects of inorganic solid particles on water and crude oil emulsion stability. Ind Eng Chem Res. 2002;41(14):3389-3404.
24. Owen R, Marlow M, Stolnik S. Macroporous surface modified microparticles. Soft Matter. 2008;4:1597-1601.
25. Jayakrishnan J, Thanoo BC. Suspension polymerization of 2-hydroxyethyl methacrylate in the presence of polymeric diluents: A novel route to spherical highly porous beads for biomedical applications. J Biomed Mater Res. 1990;24(7):913-927.
26. Li WH, Stöver HDH. Porous monodisperse poly(divinylbenzene) microspheres by precipitation polymerization. J Polym Sci A Polym Chem. 1998;36(10):1543-1551.
27. Wang RW, Zhang Y, Ma GH, Su ZG. Preparation of uniform poly(glycidyl methacrylate) porous microspheres by membrane emulsifcation-polymerization technology. J Appl Polym Sci. 2006; 102(5):5018-5027.
28. Yan R, Zhang Y, Wang X, Xu J, Wang D, Zhang W. Synthesis of porous poly(styrene-co-acrylic acid) microspheres through one-step soap-free emulsion polymerization: whys and wherefores. J Colloid Interface Sci. 2012;368(1):220-225.
29. Okubo M, Murakami Y, Fujiwara T. Formation mechanism of anomalous "golf ball-like" composite polymer particles by seeded emulsion polymerization. Colloid Polym Sci. 1996;274(6):520-524.
30. Unsal E, Elmas B, Çamli ST, Tuncel M, Şenel S, Tuncel A. Monodispersed-porous poly(styrene-co-divinylbenzene) beads providing high column effciency in reversed phase HPLC. J Appl Polym Sci. 2005;95(6):1430-1438.
31. Hosoya K, Fréchet JMJ. Infuence of the seed polymer on the chromato-graphic properties of size monodispersed polymeric sseparation media prepared by a multi-step swelling and polymerization method. J Polym Sci A Polym Chem. 1993;31(8):2129-2141.
32. Ou JN, Wu MH, Chen H. Swelling of oligomeric polystyrene seed particles to prepare porous microspheres using n-hexane as porogen. J Mater Sci Lett. 2001;20(24):2221-2223.
33. Okubo M, Ikegami K, Yamamoto Y. Preparation of micron-size mono-dispersed polymer microspheres having chloromethyl group. Colloid Polym Sci. 1989;267(3):193-200.
34. Coutinho FMB, Neves MAFS, Dias ML. Porous structure and swelling properties of styrene-divinylbenzene copolymers for size exclusion chromatography. J Appl Polym Sci. 1997;65(7):1257-1262.
35. Ugelstad J, Kaggerud KH, Hansen FK, Berge A. Absorption of low molecular weight compounds in aqueous dispersions of polymer-oligomer particles, (2) a two step swelling process of polymer particles giving an enormous increase in absorption capacity. Die Makromolekulare Chemie. 1979;180(3):737-744.
36. Zohrehvand S. On activated seed swelling technique. Polym Int. 2005;54(8):1191-1195.
37. Okubo M, Shiozaki M, Tsujihiro M, Tsukuda Y. Preparation of micron-size monodispersed polymer particles by seeded polymerization utilizing the dynamic monomer swelling method. Colloid Polymer Sci. 1991;269(3):222-226.
38. Paul W, Sharma C P. Development of porous spherical hydroxyapatite granules: application towards protein delivery. J Mater Sci Mater Med. 1999;10(7):383-388.
39. Bibby A, Mercier L. Mercury(II) ion adsorption behavior in thiol-functionalized mesoporous silica microspheres. Chem Mater. 2002; 14(4):1591-1597.
40. Pang JM, Luan YX, Li FF, Cai X, Li Z. Ionic liquid-assisted synthesis of silica particles and their application in drug release. Mater Lett. 2010;64(22):2509-2512.
41. Zhang Y, Zhi Z, Jiang T, Zhang J, Wang Z, Wang S. Spherical mes-oporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan. J Control Release. 2010;145(3):257-263.
42. Mandal TK, Bostanian TA, Graves RA, Chapman SR, Idodo TU. Porous biodegradable microparticles for delivery of pentamidine. Eur J Pharm Biopharm. 2001;52(1):91-96.
43. Straub JA, Chickering DE, Church CC, Shah B, Hanlon T, Bernstein H. Porous PLGA microparticles: AI-700, an intravenously administered ultrasound contrast agent for use in echocardiography. J Control Release. 2005;108(1):21-32.
44. Lai J P, Lu XY, Lu C Y, Ju HF, He X.W. Preparation and evaluation of molecularly imprinted polymeric microspheres by aqueous suspension polymerization for use as a high-performance liquid chromatography stationary phase. Anal Chim Acta. 2001;442(1):105-111.
45. Mayes AG, Mosbach K. Molecularly imprinted polymer beads: suspension polymerization using a liquid perfuorocarbon as the dispersing phase. Anal Chem. 1996;68(21):3769-3774.
46. Baimark Y. Porous microspheres of methoxy poly(ethylene glycol)-b-poly(ε-caprolactone-co-d,l-lactide) prepared by a melt dispersion method. Polymer. 2009;50(20):4761-4767.
47. Kim TK, Yoon JJ, Lee DS, Park TG. Gas foamed open porous biodegradable polymeric microspheres. Biomaterials. 2006;27(2):152-159.
48. Bellehumeur CT, Bisaria MK, Vlachopoulos J. An experimental study and model assessment of polymer sintering. Polym Eng Sci. 1996;36(17):2198-2207.
49. Wang Y, Shi X, Ren L, Wang C, Wang DA. Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications. Materials Science and Engineering: C. 2009;29(8):2502-2507.
50. Brown JL, Nair LS, Laurencin CT. Solvent/non-solvent sintering: A novel route to create porous microsphere scaffolds for tissue regeneration. J Biomed Mater Res B Appl Biomater. 2008;86(2): 396-406.
51. Kim K, Yeatts A, Dean D, Fisher J P. Stereolithographic bone scaffold design parameters: osteogenic differentiation and signal expression. Tissue Eng Part B Rev. 2010;16(5):523-539.
52. Wu L, Bai S, Sun Y. Development of rigid bidisperse porous micro-spheres for high-speed protein chromatography. Biotechnol Prog. 2003;19(4):1300-1306.
53. Sun HH, Li XN, Ma GH, Su ZG. Polystyrene-type uniform porous microsphere enables high resolution and low-pressure chromatography of natural products - a case study with Icariin purification. Chromatographia. 2005;61(1-2):9-15.
54. Liapis AI, McCoy MA. Theory of perfusion chromatography. J Chromatogr A. 1992;599(1-2):87-104.
55. Li Y, Gao F, Wei W, Qu JB, Ma GH, Zu WQ. Pore size of macroporous polystyrene microspheres affects lipase immobilization. J Mol Catal B Enzym. 2010;66(1-2):182-189.
56. Wang R, Zhang Y, Ma G, Su Z. Modification of poly(glycidyl methacrylate-divinylbenzene) porous microspheres with polyethylene glycol and their adsorption property of protein. Colloids Surf B Biointerfaces. 2006;51(1):93-99.
57. Ungaro F, De Rosa G, Miro A, Quaglia F, La Rotonda MI. Cyclodextrins in the production of large porous particles: Development of dry powders for the sustained release of insulin to the lungs. Eur J Pharm Sci. 2006;28(5):423-432.
58. Kim HK, Chung HJ, Park TG. Biodegradable polymeric microspheres with "open/closed" pores for sustained release of human growth hormone. J Control Release. 2006;112(2):167-174.
59. Lee PF, Zhang X W, Sun DD, Du J, Leckie JO. Synthesis of bimodal porous structured TiO2 microsphere with high photocatalytic activity for water treatment. Colloids Surf A Physicochem Eng Asp. 2008;324(1-3):202-207.
60. Molvinger K, Quignard F, Brunel D, Boissière M, Devoisselle JM. Porous chitosan-silica hybrid microspheres as a potential catalyst. Chem Mater. 2004;16(17):3367-3372.
61. Agu U, Ugwoke MI, Armand M, Kinget R, Verbeke N. The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir Res. 2001;2(4):198-209.
62. Kwon MJ, Bae JK, Jim JJ, Na K, Lee ES. Long acting porous microparti-cle for pulmonary protein delivery. Int J Pharm. 2007;333(1-2):5-9.
63. Lee ES, Kwon MJ, Na K, Bae JH. Protein release behavior from porous microparticle with lysozyme/hyaluronate ionic complex. Colloids Surf B Biointerfaces. 2007;55(1):125-130.
64. Edward DA, Hanes J, Caponetti G, et al. Large porous particles for pulmonary drug delivery. Science. 1997;276(5320):1868-1871.
65. Jiang L, Zhao Y, Zhai J. A lotus-leaf-like superhydrophobic surface: a porous microsphere/nanofber composite flm prepared by electrohy-drodynamics. Angewandte Chemie. 2004;116(33):4438-4441.
66. Jain SK, Agrawal G P, Jain NK. Evaluation of porous carrier-based foating orlistat microspheres for gastric delivery. AAPS Pharm Sci Tech. 2006;7(4):E54-E62.
67. Wang H, Wu Y, Bai Y, et al. The self-assembly of porous microspheres of tin dioxide octahedral nanoparticles for high performance lithium ion battery anode materials. J Mater Chem. 2011;21:10189-10194.
68. Chen SF, Gao F, Wang QB, Su ZG, Ma GH. Double emulsion-templated microspheres with fow-through pores at micrometer scale. Colloid Polym Sci. 2013;291(1):117-126.