Preparation and characterization of physically modified glass beads used as model carriers in dry powder inhalers

International Journal of Pharmaceutics

Volumn 447, Issue 1-2, 2013, Pages 132-138

  Zellnitz, Sarah ^a   Redlinger Pohn, Jakob Dominik ^a   Kappl, Michael ^b   Schroettner, Hartmuth ^c   Urbanetz, Nora Anne ^a  

^a RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH   (Austria)

^b MAX PLANCK INSTITUTE FOR POLYMER RESEARCH   (Germany)

^c GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Ball mill; Carrier; Dry powder inhaler; Glass beads; Surface modification

Indexed keywords

DRUG CARRIER; GLASS BEAD; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ARTICLE; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; FORCE; FRICTION; GRINDING; PARTICLE SIZE; PERFORMANCE; POWDER INHALER; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY;

DRUG CARRIERS; DRUG COMPOUNDING; DRY POWDER INHALERS; GLASS; PARTICLE SIZE; SURFACE PROPERTIES;

EID: 84875139501     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.02.044     Document Type: Article

References (34)

1. H. Adi, I. Larson, H. Chiou, P. Young, D. Traini, and P. Stewart Agglomerate strength and dispersion of salmeterol xinafoate from powder mixtures for inhalation Pharm. Res. 23 2006 2556 2565
2. H. Adi, I. Larson, and P.J. Stewart Adhesion and redistribution of salmeterol xinafoate particles in sugar-based mixtures for inhalation Int. J. Pharm. 337 2007 229 238
3. L.W. Chan, L.T. Lim, and P.W.S. Heng Immobilization of fine particles on lactose carrier by precision coating and its effect on the performance of dry powder formulations J. Pharm. Sci. 92 2003 975 984
4. D.I. Daniher, and J. Zhu Dry powder platform for pulmonary drug delivery Particuology 6 2008 225 238
5. B.H.J. Dickhoff, aH. De Boer, D. Lambregts, and H.W. Frijlink The effect of carrier surface treatment on drug particle detachment from crystalline carriers in adhesive mixtures for inhalation Int. J. Pharm. 327 2006 17 25
6. D. El-Sabawi, R. Price, S. Edge, and P.M. Young Novel temperature controlled surface dissolution of excipient particles for carrier based dry powder inhaler formulations Drug Dev. Ind. Pharm. 32 2006 243 251
7. F. Ferrari, D. Cocconi, R. Bettini, F. Giordano, P. Santi, M. Tobyn, R. Price, P. Young, C. Caramella, and P. Colombo The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer AAPS PharmSciTech. 5 2004 1 6
8. R. Guchardi, M. Frei, E. John, and J.S. Kaerger Influence of fine lactose and magnesium stearate on low dose dry powder inhaler formulations Int. J. Pharm. 348 2008 10 17
9. K. Iida, Y. Hayakawa, H. Okamoto, K. Danjo, and H. Leuenberger Evaluation of flow properties of dry powder inhalation of salbutamol sulfate with lactose carrier Chem. Pharm. Bull. 49 2001 1326 1330
10. K. Iida, Y. Hayakawa, H. Okamoto, K. Danjo, and H. Leuenberger Preparation of dry powder inhalation by surface treatment of lactose carrier particles Chem. Pharm. Bull. 51 2003 1 5
11. K. Iida, Y. Hayakawa, H. Okamoto, K. Danjo, and H. Luenberger Influence of storage humidity on the in vitro inhalation properties of salbutamol sulfate dry powder with surface covered lactose carrier Chem. Pharm. Bull. 52 2004 444 446
12. K. Iida, Y. Hayakawa, H. Okamoto, K. Danjo, and H. Luenberger Effect of surface layering time of lactose carrier particles on dry powder inhalation properties of salbutamol sulfate Chem. Pharm. Bull. 52 2004 350 353
13. K. Iida, Y. Inagaki, H. Todo, H. Okamoto, K. Danjo, and H. Luenberger Effects of surface processing of lactose carrier particles on dry powder inhalation properties of salbutamol sulfate Chem. Pharm. Bull. 52 2004 938 942
14. K. Iida, H. Todo, H. Okamoto, K. Danjo, and H. Leuenberger Preparation of dry powder inhalation with lactose carrier particles surface-coated using a Wurster fluidized bed Chem. Pharm. Bull. 53 2005 431 434
15. N. Islam, P. Stewart, I. Larson, and P. Hartley Effect of carrier size on the dispersion of salmeterol xinafoate from interactive mixtures J. Pharm. Sci. 93 2004 1030 1038
16. N. Islam, P. Stewart, I. Larson, and P. Hartley Lactose surface modification by decantation: are drug-fine lactose ratios the key to better dispersion of salmeterol xinofoate from lactose-interactive mixtures? Pharm. Res. 21 2004 492 499
17. Y. Kawashima, T. Serigano, T. Hino, H. Yamamoto, and H. Takeuchi Effect of surface morphology of carrier lactose on dry powder inhalation property of pranlukast hydrate Int. J. Pharm. 172 1998 179 188
18. Klapetek, P.; Necas, D.; Anderson, C.; 2012. Gwyddion User Guide, < http://gwyddion.net/download/user-guide/gwyddion-user-guide-en.pdf > (accessed 04.02.13).
19. H. Larhrib, G.P. Martin, C. Marriott, and D. Prime The influence of carrier and drug morphology on drug delivery from dry powder formulations Int. J. Pharm. 257 2003 283 296
20. E.M. Littringer, A. Mescher, H. Schroettner, L. Achelis, P. Walzel, and N.A. Urbanetz Spray dried mannitol carrier particles with tailored surface properties-the influence of carrier surface roughness and shape Eur. J. Pharm. Biopharm. 82 2012 194 204
21. M.D. Louey, S. Razia, and P.J. Stewart Influence of physico-chemical carrier properties on the in vitro aerosol deposition from interactive mixtures Int. J. Pharm. 252 2003 87 98
22. M.D. Louey, and P.J. Stewart Particle interactions involved in aerosol dispersion of ternary interactive mixtures Pharm. Res. 19 2002 1524 1531
23. Maas, S.G.; 2009. Optimierung trägerbasierter Pulverinhalate durch Modifikation der Trägeroberfläche mittels Sprühtrocknung, PhD thesis, Heinrich Heine University Duesseldorf.
24. S.G. Maas, G. Schaldach, E.M. Littringer, A. Mescher, U.J. Griesser, D.E. Braun, P.E. Walzel, and N.a. Urbanetz The impact of spray drying outlet temperature on the particle morphology of mannitol Powder Technol. 213 2011 27 35
25. F. Podczeck The influence of particle size distribution and surface roughness of carrier particles on the in vitro properties of dry powder inhalations Aerosol Sci. Technol. 31 1999 301 321
26. H. Steckel, P. Markefka, H. TeWierik, and R. Kammelar Effect of milling and sieving on functionality of dry powder inhalation products Int. J. Pharm. 309 2006 51 59
27. Sympatec GmbH, 2012. Fundamentals-Particle Size and Shape Calculation by Image Analysis < http://www.sympatec.com/EN/ImageAnalysis/Fundamentals.html > (accessed 04.02.13).
28. S.K. Tee, C. Marriott, X.M. Zeng, and G.P. Martin The use of different sugars as fine and coarse carriers for aerosolised salbutamol sulphate Int. J. Pharm. 208 2000 111 123
29. P.M. Young, D. Cocconi, P. Colombo, R. Bettini, R. Price, D.F. Steele, and M. Tobyn Characterization of a surface modified dry powder inhalation carrier prepared by particle smoothing J. Pharm. Pharmacol. 2002 1339 1344
30. P.M. Young, D. Roberts, H. Chiou, W. Rae, H.-K. Chan, and D. Traini Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery J. Aerosol Sci. 39 2008 82 93
31. X.M. Zeng, G.P. Martin, C. Marriott, and J. Pritchard The influence of crystallization conditions on the morphology of lactose intended for use as a carrier for dry powder aerosols J. Pharm. Pharmacol. 52 2000 633 643
32. X.M. Zeng, G.P. Martin, C. Marriott, and J. Pritchard Crystallization of lactose from carbopol gels Pharm. Res. 17 2000 879 886
33. X.M. Zeng, G.P. Martin, C. Marriott, and J. Pritchard The use of lactose recrystallised from carbopol gels as a carrier for aerosolised salbutamol sulphate Eur. J. Pharm. Biopharm. 51 2001 55 62
34. X.M. Zeng, G.P. Martin, C. Marriott, and J. Pritchard Lactose as a carrier in dry powder formulations: the influence of surface characteristics on drug delivery J. Pharm. Sci. 90 2001 1424 1434