In vitro combined cytotoxic effects of pesticide cocktails simultaneously found in the French diet

Food and Chemical Toxicology

Volumn 52, Issue , 2013, Pages 153-162

  Takakura, Natsuko ^a   Sanders, Pascal ^a   Fessard, Valérie ^a   Le Hégarat, Ludovic ^a  

^a FRENCH AGENCY FOR FOOD   (France)

Author keywords

Combined effect; Cytotoxicity; French diet; Pesticide mixture

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CAPTAN; CASPASE 3; CASPASE 7; CHLORPHENOTANE; DIELDRIN; DIPHENYLAMINE; ENVIRONMENTAL CHEMICAL; NEUTRAL RED; PESTICIDE; PHOSALONE; PROPARGITE; REACTIVE OXYGEN METABOLITE; TOLYLFLUANID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRAIN CACO 2; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY TEST; DIET; ENZYME ACTIVITY; FRENCH DIET; HUMAN; HUMAN CELL; IN VITRO STUDY;

CACO-2 CELLS; CASPASE 3; CASPASE 7; CELL LINE; DDT; DIELDRIN; FOOD CONTAMINATION; FOOD HABITS; FRANCE; HUMANS; MODELS, THEORETICAL; PESTICIDES; REACTIVE OXYGEN SPECIES; RISK ASSESSMENT;

EID: 84875086661     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.11.011     Document Type: Article

References (31)

1. Altenburger R., Nendza M., Schuurmann G. Mixture toxicity and its modeling by quantitative structure-activity relationships. Environ. Toxicol. Chem. 2003, 22:1900-1915.
2. Borgert C.J., Quill T.F., McCarty L.S., Mason A.M. Can mode of action predict mixture toxicity for risk assessment?. Toxicol. Appl. Pharmacol. 2004, 201:85-96.
3. Crépet A., Tressou J. Bayesian nonparametric model for clustering individual co-exposure to pesticides found in the French diet. Bayesian Anal. 2011, 6:127-144.
4. Crépet, A., Tressou, J., Graillot, V., Béchaux, C., Pierlot, S., Héraud, F., Leblanc, J.C., in press. Identification of the main pesticide residue cocktails to which the French population is exposed: a Bayesian approach. Environ. Res.
5. Dubuisson C., Lioret S., Touvier M., Dufour A., Calamassi-Tran G., Volatier J.L., Lafay L. Trends in food and nutritional intakes of French adults from 1999 to 2007: results from the INCA surveys. Br. J. Nutr. 2010, 103:1035-1048.
6. EFSA Scientific opinion on risk assessment for a selected group of pesticides from the triazole group to test possible methodologies to assess cumulative effects from exposure through food from these pesticides on human. EFSA J. 2009, 7:1167.
7. EFSA 2008 annual report on pesticide residues according to article 32 of regulation (EC) No. 396/2005. EFSA J. 2010, 8:1646.
8. Faust M., Altenburger R., Backhaus T., Blanck H., Boedeker W., Gramatica P., Hamer V., Scholze M., Vighi M., Grimme L.H. Joint algal toxicity of 16 dissimilarly acting chemicals is predictable by the concept of independent action. Aquat. Toxicol. 2003, 63:43-63.
9. Frigo D.E., Vigh K.A., Struckhoff A.P., Elliott S., Beckman B.S., Burow M.E., McLachlan J.A. Xenobiotic-induced TNF-alpha expression and apoptosis through the p38 MAPK signaling pathway. Toxicol. Lett. 2005, 155:227-238.
10. Goldoni M., Johansson C. A mathematical approach to study combined effects of toxicants in vitro: evaluation of the Bliss independence criterion and the Loewe additivity model. Toxicol. In Vitro 2007, 21:759-769.
11. Graillot V., Takakura N., Hegarat L.L., Fessard V., Audebert M., Cravedi J.P. Genotoxicity of pesticide mixtures present in the diet of the French population. Environ. Mol. Mutagen. 2012, 53:173-184.
12. Groten J.P., Feron V.J., Suhnel J. Toxicology of simple and complex mixtures. Trends Pharmacol. Sci. 2001, 22:316-322.
13. Hreljac I., Zajc I., Lah T., Filipic M. Effects of model organophosphorous pesticides on DNA damage and proliferation of HepG2 cells. Environ. Mol. Mutagen. 2008, 49:360-367.
14. Kortenkamp A., Faust M., Scholze M., Backhaus T. Low-level exposure to multiple chemicals: reason for human health concerns?. Environ. Health Perspect. 2007, 115(Suppl 1):106-114.
15. Lioret S., Dubuisson C., Dufour A., Touvier M., Calamassi-Tran G., Maire B., Volatier J.L., Lafay L. Trends in food intake in French children from 1999 to 2007: results from the INCA (etude Individuelle Nationale des Consommations Alimentaires) dietary surveys. Br. J. Nutr. 2010, 103:585-601.
16. Mills P.K., Yang R.C. Agricultural exposures and gastric cancer risk in Hispanic farm workers in California. Environ. Res. 2007, 104:282-289.
17. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
18. Osseni R.A., Debbasch C., Christen M.O., Rat P., Warnet J.M. Tacrine-induced reactive oxygen species in a human liver cell line: the role of Anethole dithiolethione as a scavenger. Toxicol. In Vitro 1999, 13:683-688.
19. Payne J., Scholze M., Kortenkamp A. Mixtures of four organochlorines enhance human breast cancer cell proliferation. Environ. Health Perspect. 2001, 109:391-397.
20. Perez-Maldonado I.N., Diaz-Barriga F., de la Fuente H., Gonzalez-Amaro R., Calderon J., Yanez L. DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children. Environ. Res. 2004, 94:38-46.
21. Rajapakse N., Silva E., Scholze M., Kortenkamp A. Deviation from additivity with estrogenic mixtures containing 4-nonylphenol and 4-tert-octylphenol detected in the E-SCREEN assay. Environ. Sci. Technol. 2004, 38:6343-6352.
22. Reffstrup T.K., Larsen J.C., Meyer O. Risk assessment of mixtures of pesticides. Current approaches and future strategies. Regul. Toxicol. Pharmacol. 2010, 56:174-192.
23. Repetto G., del Peso A., Zurita J.L. Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat. Protoc. 2008, 3:1125-1131.
24. Snedeker S.M. Pesticides and breast cancer risk: a review of DDT, DDE, and dieldrin. Environ. Health Perspect. 2001, 109(Suppl 1):35-47.
25. Tarone R.E. DDT and breast cancer trends. Environ. Health Perspect. 2008, 116:A374.
26. UIPP Rapport d'activité 2009, Union des Industries de la Protection des Plantes, Boulogne.
27. US-EPA Guidelines for Carcinogen Risk Assessment 1986, Environmental Protection Agency, US.
28. US-EPA Reregistration Eligibility Decision for propargite Case No. 0243 2001, Office of Pesticide Programs, Washington, DC.
29. US-EPA Status of Cumulative Risk Assessment for Organophosphate Pesticides 2002, Office of Pesticide Programs, Washinton, DC.
30. Van Audenhaege M., Heraud F., Menard C., Bouyrie J., Morois S., Calamassi-Tran G., Lesterle S., Volatier J.L., Leblanc J.C. Impact of food consumption habits on the pesticide dietary intake: comparison between a French vegetarian and the general population. Food Addit. Contam. Part A, Chem. Anal. Control. Expo. Risk Assess. 2009, 26:1372-1388.
31. Zhou X., Sang W., Liu S., Zhang Y., Ge H. Modeling and prediction for the acute toxicity of pesticide mixtures to the freshwater luminescent bacterium Vibrio qinghaiensis sp.-Q67. J. Environ. Sci. (China) 2010, 22:433-440.