Exenatide at therapeutic and supratherapeutic concentrations does not prolong the QTc interval in healthy subjects

British Journal of Clinical Pharmacology

Volumn 75, Issue 4, 2013, Pages 979-989

  Darpö, Börje ^a   Philip, Sager ^b   Macconell, Leigh ^c   Cirincione, Brenda ^c   Mitchell, Malcolm ^d   Han, Jenny ^c   Huang, Wenying ^c   Malloy, Jaret ^c   Schulteis, Christine ^c   Shen, Larry ^c   Porter, Lisa ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Sager Consulting Partners   (United States)

^c AMYLIN PHARMACEUTICALS INC   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

Cardiac repolarization; Exenatide; Thorough QT QTc study

Indexed keywords

EXENDIN 4; MOXIFLOXACIN; PLACEBO;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; BODY MASS; CONCENTRATION RESPONSE; CONTINUOUS INFUSION; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; ELECTROCARDIOGRAPHY; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; HYPOGLYCEMIA; MAJOR CLINICAL STUDY; MALE; NAUSEA; PATIENT MONITORING; POPULATION RESEARCH; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY ANALYSIS; SIDE EFFECT; SINGLE DRUG DOSE; STEADY STATE; TREATMENT DURATION; VOMITING;

ADOLESCENT; ADULT; AGED; ANTI-BACTERIAL AGENTS; AZA COMPOUNDS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRAVENOUS; LONG QT SYNDROME; MALE; MIDDLE AGED; PEPTIDES; QUINOLINES; VENOMS;

EID: 84875077076     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04416.x     Document Type: Article

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