Decreasing blood loss and the need for transfusion after CABG surgery: A double-blind randomized clinical trial of topical tranexamic acid

Turkish Journal of Medical Sciences

Volumn 43, Issue 2, 2013, Pages 273-278

  Nouraei, Mahmoud ^a   Gholipour Baradari, Afshin ^a   Ghafari, Rahman ^a   Habibi, Mohammad Reza ^a   Emami Zeydi, Amir ^a   Sharifi, Narges ^a  

^a MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Bypass surgery; Coronary artery; Postoperative hemorrhage; Tranexamic acid

Indexed keywords

PLACEBO; TRANEXAMIC ACID;

ADULT; ARTICLE; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ERYTHROCYTE TRANSFUSION; FEMALE; HEART INFARCTION; HUMAN; KIDNEY FAILURE; MALE; OUTCOME ASSESSMENT; POSTOPERATIVE HEMORRHAGE; RANDOMIZED CONTROLLED TRIAL; SEIZURE; STERNOTOMY; THERAPY EFFECT; THROMBOCYTE TRANSFUSION; TREATMENT RESPONSE; WOUND CLOSURE;

EID: 84875067540     PISSN: 13000144     EISSN: None     Source Type: Journal    
DOI: 10.3906/sag-1206-37     Document Type: Article

References (34)

1. Bostan M, Şati{dotless}roǧlu O, Uydu HA, Cicek Y, Canga A, Karadaǧ Z et al. Distribution of coronary artery risk factors: a regional analysis. Turk J Med Sci 2011; 41: 317-24.
2. Nalysnyk L, Fahrbach K, Reynolds MW, Zhao SZ, Ross S. Adverse events in coronary artery bypass graft (CABG) trials: a systemic review and analysis. Heart 2003; 89: 767-72.
3. Santos AT, Kalil RA, Bauemann C, Pereira JB, Nesralla IA. A randomized double-blind and placebo-controlled study with tranexamic acid of bleeding and fibrinolytic activity after primary coronary bypass grafting. Braz J Med Biol Res 2006; 39: 63-9.
4. Pleym H, Stenseth R, Wahba A, Bjella L, Karevold A, Dale O. Single dose tranexamic acid reduces post-operative bleeding after coronary surgery in patients treated with aspirin until surgery. Anesth Analg 2003; 96: 923-8.
5. Andreasen J, Nielson C. Prophylactic tranexamic acid in elective, primary coronary artery bypasses surgery using cardiopulmonary bypass. Eur J Cardiothorac Surg 2004; 26: 311-7.
6. Snyder-Ramos SA, Mohnle P, Weng YS, Bottiger BW, Kulier A, Levin J et al. The ongoing variability in blood transfusion practices in cardiac surgery. Transfusion 2008; 48: 1284-99.
7. Fawzy H, Elmistekawy E, Bonneau D, Latter D, Errett L. Can local application of tranexamic acid reduce postcoronary bypass surgery blood loss? A randomized controlled trial. J Cardiothorac Surg 2009; 4: 25.
8. Ashworth A, Klein AA. Cell salvage as part of a blood conservation strategy in anaesthesia. Br J Anaesth 2010; 105: 401-16.
9. Unlu Y, Tekin SB, Kocak H. Levels of protein c and protein s, tissue-plasminogen activator, and fibrinogen during cardiopulmonary bypass. Turk J Med Sci 2007; 37: 345-50.
10. Hertfelder HJ, Bos M, Weber D, Winkler K, Hanfland P, Preusse CJ. Perioperative monitoring of primary and secondary hemostasis in coronary artery bypass grafting. Semin Thromb Hemost 2005; 31: 426-40.
11. Engoren MC, Habib RH, Zacharias A, Schwann TA, Riordan CJ, Durham SJ. Effect of blood transfusion on long-term survival after cardiac operation. Ann Thorac Surg 2002; 74: 1180-6.
12. Jimenez Rivera JJ, Iribarren JL, Raya JM, Nassar I, Lorente L, Perez R et al. Factors associated with excessive bleeding in cardiopulmonary bypass patients: a nested case-control study. J Cardiothorac Surg 2007; 2: 17.
13. Jakobsen CJ, Ryhammer PK, Tang M, Andreasen JJ, Mortensen PE. Transfusion of blood during cardiac surgery is associated with higher long-term mortality in low-risk patients. European J Cardiothorac Surg 2012; 42: 114-20.
14. Paone G, Brewer R, Theurer PF, Bell GF, Cogan CM, Prager R et al. Preoperative predicted risk does not fully explain the association between red blood cell transfusion and mortality in coronary artery bypass grafting. J Thorac Cardiovasc Surg 2012; 143: 178-85.
15. Christensen MC, Krapf S, Kempel A, Heymann CV. Costs of excessive postoperative hemorrhage in cardiac surgery. J Thorac Cardiovasc Surg 2009; 138: 687-93.
16. Mehr-Aein A, Davoodi S, Madani Givi M. Comparison of effects of auto transfusion and tranexamic acid on post cardiopulmonary bypass bleeding. Tehran Univ Med J 2003; 61: 450-6.
17. Ipema HJ. Use of topical tranexamic acid or aminocaproic acid to prevent bleeding after major surgical procedures. Ann Pharmacother 2012; 46: 97-107.
18. Zuffery P, Merquiol F. Do antifibrinolytics reduce allogeneic transfusion in orthopedic surgery? Anesthesiology 2006; 105: 1034-46.
19. Samama CM. Aprotinin and major orthopedic surgery. Eur Spine J 2004; 13: S1-6.
20. Clark AD, Gordon WC, Walker ID, Tait RC. 'Last-ditch' use of recombinant factor VIIa in patients with massive haemorrhage is ineffective. Vox Sang 2004; 86: 120-4.
21. Erstad BL. What is the evidence for using hemostatic agents in surgery? Eur Spine J 2004; 13: S1-28.
22. Abrishami A, Chung F, Wong J. Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systemic review and meta-analysis. Can J Anaesth 2009; 56: 202-12.
23. Mehr-Aein A, Sadeghi M, Madani-civi M. Does tranexamic acid reduce blood loss in off-pump coronary artery bypass? Asian Cardiovasc Thorac Ann 2007; 15: 285-9.
24. Adler Ma SC, Brindle W, Burton G, Gallacher S, Hong FC, Manelius I et al. Tranexamic acid is associated with less blood transfusion in off-pump coronary artery bypass graft surgery: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth 2011; 25: 26-35.
25. Dryden PJ, O'Connor JP, Jamieson WR, Reid I, Ansley D, Sadeghi H et al. Tranexamic acid reduces blood loss and transfusion in reoperative cardiac surgery. Can J Anaesth 1997: 44: 913-7.
26. De Bonis M, Cavaliere F, Alessandrini F, Lapenna E, Santarelli F, Moscato U et al. Topical use of tranexamic acid in coronary artery bypass operation: a double-blind, prospective, randomized, placebo-controlled study. J Thorac Cardiovascular Surg 2000; 119: 575-80.
27. Abdul-Azm A, Abdullah KM. Effect of topical tranexamic acid in open heart surgery. Eur J Anaesthesiol 2006; 23: 380-4.
28. Ghaffari Nejad MH, Baharestani B, Esfandiari R, Hashemi J, Panahipoor A. Evaluation and comparison of using lowdose aprotinin and tranexamic acid in CABG: a double blind randomized clinical trial. J Teh Univ Heart Ctr 2012; 7: 15-8.
29. Spegar J, Vanek T, Snircova J, Fajt R, Straka Z, Pazderkova P et al. Local and systemic application of tranexamic acid in heart valve surgery: a prospective, randomized, double blind LOST study. J Thromb Thrombolysis 2011; 32: 303-10.
30. Baric D, Biocina B, Unic D, Sutlic Z, Rudez I, Vrca VB et al. Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study. Eur J Cardiothorac Surg 2007; 31: 366-71.
31. Bell D, Marasco S, Almeida A, Rowland M. Tranexamic acid in cardiac surgery and postoperative seizures: a case report series. Heart Surg Forum 2010; 13: E257-9.
32. Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M. Highdose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg 2010; 110: 350-3.
33. Montes FR, Pardo DF, Carreno M, Arciniegas C, Dennis RJ, Umana JP. Risk factors associated with postoperative seizures in patients undergoing cardiac surgery who received tranexamic acid: a case-control study. Ann Card Anaesth 2012; 15: 6-12.
34. Manji RA, Grocott HP, Leake J, Ariano RE, Manji JS, Menkis AH et al. Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. Can J Anaesth 2012; 59: 6-13.