Can local application of Tranexamic acid reduce post-coronary bypass surgery blood loss? A randomized controlled trial

Journal of Cardiothoracic Surgery

Volumn 4, Issue , 2009, Pages

  Fawzy, Hosam ^a   Elmistekawy, Elsayed ^a   Bonneau, Daniel ^a   Latter, David ^a   Errett, Lee ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBRINOLYTIC AGENT; TRANEXAMIC ACID;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; PEROPERATIVE CARE; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE TRANSFUSION; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME; UTILIZATION REVIEW;

ADMINISTRATION, TOPICAL; ANTIFIBRINOLYTIC AGENTS; CORONARY ARTERY BYPASS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTRAOPERATIVE CARE; MALE; MIDDLE AGED; PLATELET TRANSFUSION; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDIES; TRANEXAMIC ACID; TREATMENT OUTCOME;

EID: 67650718369     PISSN: None     EISSN: 17498090     Source Type: Journal    
DOI: 10.1186/1749-8090-4-25     Document Type: Article

References (22)

1. Kucuk O Kwaan HC Frederickson J Wade L Green D Increased fibrinolytic activity in patients undergoing cardiopulmonary bypass operation Am J Hematol 1986, 23:223-9 10.1002/ajh.2830230306 3766524
2. Harker LA Malpass TW Branson HE Hessel EA II Slichter SJ Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release Blood 1980, 56:824-34 6448643
3. Depotis GJ Santoro SA Spitznagel E Kater KM Cox JL Barnes P Prospective evaluation and clinical utility of on-site monitoring of coagulation in patients undergoing cardiac operation J Thorac Cardiovasc Surg. 1994, 107(1):271-279 8283896
4. Lemmer JH Jr Stanford W Bonney SL Breen JF Chomka EV Elderge WJ Aprotonin for coronary bypass operations: Efficacy, safety, and influence on early saphenous graft patency-a multicenter, randomized, double blind, placebo-controlled study J Thorac Cardiovasc Surg 1994, 107:543-53 7508070
5. Daily PO Lamphere JA Dembitsky WP Adamson RM Dans NF Effect of prophylactic epsilon-aminocaproic acid on blood loss and transfusion requitments in patients undergoing first-time coronary artery bypass grafting: A randomized, prospective, double-blind study J Thorac Cardiovasc Surg 1994, 108:99-105 8028387
6. Kevy SV Glickman RM Bernhard WF Diamond LK Grass RE The pathogenesis and control of the hemorrhagic defect in open heart surgery Surg Gynecol Obstet 1966, 123:313-8 5913482
7. Cosgrove DM III Heric B Lytle BW Taylor PC Novoa R Golding LA Aprotonin therapy for reoperative myocardial revascularization: A placebo-controlled study Ann Thorac Surg 1992, 54:1031-8 1280411
8. Horrow JC Van Riper DF Strong MD Brodsky I Parmet JL Haemostatic effects of Tranexamic acid and Desmopressin during cardiac surgery Circulation 1991, 84:2063-70 1934382
9. Longstaff C Studies on the mechanisms of action of Aprotonin and Tranexamic acid as plasmin inhibitors and antifibrinolytic agents Blood Coagul Fibrinolysis 1994, 5:537-42 7531000
10. Ovrum E Holen EA Abdelnoor M Oystese R Ringdal ML Tranexamic acid (Cyklokapron) in not necessary to reduce blood loss after coronary artery operations J Thorac Cardivasc Surg 1993, 105:78-83
11. Versraette M Clinical application of inhibitors of fibrionolysis Drugs 1985, 29:236-61 10.2165/00003495-198529030-00003 2580684
12. Valsecchi A Further notes on the topical use of Tranexamic acid in the treatment of gynaecological haemorrhage Minerva Ginecol 1980, 32:825-30 7219835
13. Sindet-Pedersen S Ramtro G Bernvil S Blomback M Haemostatic effect of tranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery N Engl J Med 1989, 320:840-3 2648144
14. Henry D Carless P Fergusson D Laupacis A The safety of aprotinin and lysine-derived antifibrinolytic drugs in cardiac surgery: A meta-analysis CMAJ 2009, 180(2):183-93 2621296 19050037
15. Alderman EL Levy JH Rich JB Analyses of coronary graft patency after Aprotinin use: Results from the International Multicenter Aprotinin Graft Patency Experience study (IMAGE) trial J Thorac Cardiovasc Surg 1998, 116:716-730 10.1016/S0022-5223(98)00431-0 9806378
16. Tatar H Ciçek S Demirkiliç U Ozal E Süer H Oztürk O Işiklar H Topical use of Aprotonin in open heart operations Ann Thorac Surg 1993, 55:659-61 7680853
17. O' Regan DJ Giannopoulos N Mediratta N Kendall SWH Forni A Pillai R Topical Aprotonin in cardiac operations Ann Thorac Surg 1994, 58:778-81 7524457
18. Khalil PN Ismail M Kalmar P von Knobelsdorff G Marx G Activation of fibrinolysis in the pericardial cavity after cardiopulmonary bypass Thromb Haemost 2004, 92:568-574 15351853
19. De Bonis M Cavaliere F Alessandrini F Lapenna E Santarelli F Moscato U Schiavello R Poosti GF Topical use of Tranexamic acid in coronary artery bypass operations: A double-blind, prospective, randomized, placebo-controlled study J Thorac Cardiovasc Surg 2000, 119:575-80 10.1016/S0022-5223(00)70139-5 10694619
20. Abdul-Azm A Abdullah KM Effect of topical Tranexamic acid in open heart surgery Eur J Anaesthesiol. 2006, 23(5):380-384 10.1017/ S0265021505001894 16438759
21. Yasim A Asik R Atahan E Effects of topical applications of Aprotinin and Tranexamic acid on blood loss after open heart surgery [abstract] Anadolu Kardiyol Derg 2005, 5:36 15755701
22. Abrishami A Chung F Wong J Topical application of antifibrinolytic drugs for on-pump cardiac surgery: A systemic review and meta-analysis Can J Anaesth 2009, 56:202-12 10.1007/s12630-008-9038-x 19247741