Erythrocyte and reticulocyte indices in the assessment of erythropoiesis activity and iron availability

International Journal of Laboratory Hematology

Volumn 35, Issue 2, 2013, Pages 144-149

  Urrechaga, E ^a   Borque, L ^b   Escanero, J F ^b  

^a HOSPITAL DE GALDAKAO   (Spain)

^b UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

Erythropoiesis; Hemodialysis; Hypochromic erythrocyte; Iron availability; Reticulocyte hemoglobin content

Indexed keywords

ANTIANEMIC AGENT; FERRITIN; FERROUS GLUCONATE; IRON;

ADULT; AGED; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; ERYTHROCYTE PARAMETERS; ERYTHROPOIESIS; FEMALE; HEMODIALYSIS; HUMAN; IRON DEFICIENCY ANEMIA; IRON DEPLETION; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; PRIORITY JOURNAL; RETICULOCYTE HEMOGLOBIN CONTENT; SENSITIVITY AND SPECIFICITY; UREMIA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEMIA, IRON-DEFICIENCY; AUTOMATION; CLINICAL CHEMISTRY TESTS; DIALYSIS; ERYTHROPOIESIS; FEMALE; FLOW CYTOMETRY; HUMANS; IRON; MALE; MIDDLE AGED; REFERENCE STANDARDS; RENAL INSUFFICIENCY, CHRONIC; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 84875055006     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/ijlh.12013     Document Type: Article

References (31)

1. Cavill I. Functional iron deficiency. Blood 1993;82:137.
2. Fishbane S, Imbriano LJ, Kowalski EA, Maesaka JK. The evaluation of iron status in patients receiving recombinant human erythropoietin. Journal of the American Society of Nephrology 1996;7:654-7.
3. Mast A. The clinical utility of peripheral blood tests in the diagnosis of iron deficiency anemia. Bloodline 2001;1:7-9.
4. Coyne D. Iron indices: what do they really mean? Kidney Inter 2006;101:S4-8.
5. Macdougall IC, Cavill I, Hulme B, Bain B, Mcgregor E, Mckay P, Sanders E, Coles GA, Williams JD. Detection of functional iron-deficiency during erythropoietin treatment - a new approach. BMJ 1992;304:225-6.
6. Navarro JF, Macia ML. Hypochromic red cells as an indicator of iron deficiency. J Rheumatol 1997;24:804-5.
7. Fishbane S, Galgano C, Langley RC Jr, Canfield W, Maesaka JK. Reticulocyte hemoglobin content in the evaluation of iron status of hemodialysis patients. Kidney Int 1997;52:217-22.
8. Mast AE, Blinder MA, Lu Q, Flax S, Dietzen DJ. Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency. Blood 2002;99:1489-91.
9. Brugnara C. Iron deficiency and erythropoiesis: New diagnostic approaches. Clin Chem 2003;49:1573-8.
10. Macdougall IC. Merits of hypochromic red cells as a marker of functional iron deficiency. Nephrol Dial Transplant 1998;13:847-9.
11. Bovy C, Gothot A, Krzesinski JM, Beguin Y. Mature erythrocyte indices: new markers of iron availability. Haematologica 2005;90:549-51.
12. Macdougall IC, Horl WH, Jacobs C, Valderrabano F, Parrondo I, Thompson K, Cremers S. European best practice guidelines 6-8: assessing and optimizing iron stores. Nephrol Dial Transplant 2000;15:20-32.
13. Kotisaari S, Romppanen J, Penttila I, Punnonen K. The Advia 120 red blood cell and reticulocyte indices are useful in diagnosis of iron-deficiency anemia. Eur J Hematol 2002;68:150-6.
14. Locateli F, Aljama P, Barany P, Canaud B, Carrera F, Eckardt KU, Horl WH, Macdougall IC, Macleod A, Wiecek A, Cameron S, European Best Practice Guidelines Working Group. Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure. Nephrol Dial Transplant 2004;19(Suppl. 2):1-47.
15. Buttarello M, Temporin V, Ceravolo R, Farina G, Burian P. The new reticulocyte parameter RET Y of the Sysmex XE 2100. Its use in the diagnosis and monitoring of post treatment sideropenic anemia. Am J Clin Pathol 2004;121:489-95.
16. Thomas L, Franck S, Messinger M, Linssen J, Thome M, Thomas C. Reticulocyte hemoglobin measurement - comparison of two methods in the diagnosis of iron-restricted erythropoiesis. Clin Chem Lab Med 2005;43:1193-202.
17. Garzia M, Di Mario A, Ferraro E, Tazza L, Rossi E, Luciani G, Zini G. (2007) Reticulocyte Hemoglobin Equivalent: an indicator of reduced iron availability in chronic kidney diseases during erythropoietin therapy. Lab Haematol 2007;13:6-11.
18. David O, Grillo A, Ceoloni B, Cavallo F, Podda G, Biancotti PP, Bergamo D, Canavese C. (2006) Analysis of red cell parameters on the Sysmex XE 2100 and Advia 120 in iron deficiency and in uraemic chronic disease. Scand J Clin Lab Invest 2006;66:113-20.
19. Mast AE, Blinder MA, Dietzen DJ. Reticulocyte haemoglobin content. Am J Hematol 2008;83:307-10.
20. Urrechaga E, Borque L, Escanero JF. Potential utility of the new Sysmex XE 5000 red blood cell extended parameters in the study of disorders of iron metabolism. Clin Chem Lab Med 2009;47:1411-6.
21. Urrechaga E, Borque L, Escanero JF. The role of automated measurement of red cell subpopulations on the Sysmex XE 5000 analyzer in the differential diagnosis of microcytic anemia. Int J Lab Hematol 2011a;33:30-6.
22. Urrechaga E, Borque L, Escanero JF. The role of automated measurement of red cell subpopulations in differential diagnosis of microcytic anemia and β thalassemia screening. Am J Clin Pathol 2011b;135:374-9.
23. Buttarello M, Pajola R, Novello E, Rebeschini M, Cantaro S, Oliosi F, Naso A, Plebani M. Diagnosis of iron deficiency in patients undergoing hemodialysis. Am J Clin Pathol 2010;133:949-54.
24. Urrechaga E, Borque L, Escanero JF. Percentage of hypochromic erythrocytes as potential marker of iron availability. Clin Chem Lab Med 2012;50:685-7.
25. Eschbach JW, Downing MR, Egrie JC, Browne JK, Adamson JW. USA multicenter clinical trial with recombinant human erythropoietin. Contrib Nephrol 1989;76:160-5.
26. Cavil I, Macdougall IC. Erythropoiesis and iron supply in patients treated with Erythropoietin. Erythropoiesis 1992;3:50-5.
27. Macdougall IC. Poor response to erythropoietin: Practical guidelines on investigation and management. Nephrol Dial Transplant 1995;10:607-14.
28. Tessitore N, Solero GP, Lippi G, Bassi A, Faccini GB, Bedogna V. The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erythropoietin. Nephrol Dial Transplant 2001;16:1416-23.
29. Canals C, Remacha AF, Sarda MP, Piazuelo JM, Royo MT, Romero MA. Clinical utility of the new Sysmex XE 2100 parameter reticulocyte hemoglobin equivalent in the diagnosis of anemia. Haematologica 2005;90:1133-4.
30. Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta 2003;329:9-22.
31. Maconi M, Cavalca I, Danise P, Cardrelli F, Brini M. (2009) Erythrocyte and reticulocyte indices in chronic kidney diseases: comparison of two methods. Scand J Clin Lab Invest 2009;69:365-70.