Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE-/- mice

Atherosclerosis

Volumn 227, Issue 2, 2013, Pages 236-243

  Olivon, Vania C ^a   Fraga Silva, Rodrigo A ^e   Segers, Dolf ^b   Demougeot, Céline ^c   de Oliveira, Ana M ^a   Savergnini, Silvia S ^e   Berthelot, Alain ^c   de Crom, Rini ^c   Krams, Rob ^d   Stergiopulos, Nikos ^e   da Silva, Rafaela F ^f  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c France   (France)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e EPFL   (Switzerland)

^f FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Arginase; Atherosclerosis; Vulnerable and stable plaques; Wall shear stress

Indexed keywords

APOLIPOPROTEIN E; ARGINASE; COLLAGEN; ENZYME INHIBITOR; ISOPROTEIN; LIPID; REACTIVE OXYGEN METABOLITE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY; COLORIMETRY; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHEAR STRESS;

ANIMALS; APOLIPOPROTEINS E; APOPTOSIS; ARGINASE; ARGININE; ATHEROSCLEROSIS; BIOMECHANICS; CAROTID ARTERIES; CELL PROLIFERATION; COLLAGEN; HEMODYNAMICS; LIPIDS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLAQUE, ATHEROSCLEROTIC; REACTIVE OXYGEN SPECIES; SHEAR STRENGTH; STRESS, MECHANICAL; TIME FACTORS;

EID: 84875054553     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.12.014     Document Type: Article

References (34)

1. Cheng C., van Haperen R., de Waard M., et al. Shear stress affects the intracellular distribution of enos: direct demonstration by a novel in vivo technique. Blood 2005, 106:3691-3698.
2. Gambillara V., Chambaz C., Montorzi G., Roy S., Stergiopulos N., Silacci P. Plaque-prone hemodynamics impair endothelial function in pig carotid arteries. Am J Physiol Heart Circ Physiol 2006, 290:H2320-H2328.
3. Gambillara V., Montorzi G., Haziza-Pigeon C., Stergiopulos N., Silacci P. Arterial wall response to ex vivo exposure to oscillatory shear stress. J Vasc Res 2005, 42:535-544.
4. Cheng C., Tempel D., van Haperen R., et al. Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation 2006, 113:2744-2753.
5. Chatzizisis Y.S., Jonas M., Coskun A.U., et al. Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study. Circulation 2008, 117:993-1002.
6. Koskinas K.C., Chatzizisis Y.S., Baker A.B., Edelman E.R., Stone P.H., Feldman C.L. The role of low endothelial shear stress in the conversion of atherosclerotic lesions from stable to unstable plaque. Curr Opin Cardiol 2009, 24:580-590.
7. Dickson B.C., Gotlieb A.I. Towards understanding acute destabilization of vulnerable atherosclerotic plaques. Cardiovasc Pathol 2003, 12:237-248.
8. Johnson F.K., Johnson R.A., Peyton K.J., Durante W. Arginase inhibition restores arteriolar endothelial function in dahl rats with salt-induced hypertension. Am J Physiol Regul Integr Comp Physiol 2005, 288:R1057-R1062.
9. Kim J.H., Bugaj L.J., Oh Y.J., et al. Arginase inhibition restores nos coupling and reverses endothelial dysfunction and vascular stiffness in old rats. J Appl Physiol 2009, 107:1249-1257.
10. Ryoo S., Gupta G., Benjo A., et al. Endothelial arginase ii: a novel target for the treatment of atherosclerosis. Circ Res 2008, 102:923-932.
11. Ryoo S., Lemmon C.A., Soucy K.G., et al. Oxidized low-density lipoprotein-dependent endothelial arginase ii activation contributes to impaired nitric oxide signaling. Circ Res 2006, 99:951-960.
12. Ash D.E. Structure and function of arginases. J Nutr 2004, 134:2760S-2764S. [discussion 2765S-2767S].
13. Durante W., Johnson F.K., Johnson R.A. Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin Exp Pharmacol Physiol 2007, 34:906-911.
14. Yang L., Lewis C.M., Chandrasekharan U.M., Kinney C.M., Dicorleto P.E., Kashyap V.S. Arginase activity is increased by thrombin: a mechanism for endothelial dysfunction in arterial thrombosis. J Am Coll Surg 2006, 203:817-826.
15. Zhu W., Chandrasekharan U.M., Bandyopadhyay S., Morris S.M., DiCorleto P.E., Kashyap V.S. Thrombin induces endothelial arginase through ap-1 activation. Am J Physiol Cell Physiol 2010, 298:C952-C960.
16. Peyton K.J., Ensenat D., Azam M.A., et al. Arginase promotes neointima formation in rat injured carotid arteries. Arterioscler Thromb Vasc Biol 2009, 29:488-494.
17. Bagnost T., Ma L., da Silva R.F., et al. Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension. Cardiovasc Res 2010, 87:569-577.
18. Demougeot C., Prigent-Tessier A., Bagnost T., et al. Time course of vascular arginase expression and activity in spontaneously hypertensive rats. Life Sci 2007, 80:1128-1134.
19. Durante W., Liao L., Reyna S.V., Peyton K.J., Schafer A.I. Physiological cyclic stretch directs l-arginine transport and metabolism to collagen synthesis in vascular smooth muscle. FASEB J 2000, 14:1775-1783.
20. Thacher T.N., Gambillara V., Riche F., Silacci P., Stergiopulos N., da Silva R.F. Regulation of arginase pathway in response to wall shear stress. Atherosclerosis 2010, 210:63-70.
21. Bagnost T., Berthelot A., Bouhaddi M., et al. Treatment with the arginase inhibitor n(omega)-hydroxy-nor-l-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat. J Hypertens 2008, 26:1110-1118.
22. Kropf P., Fuentes J.M., Fahnrich E., et al. Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo. FASEB J 2005, 19:1000-1002.
23. Cheng C., Tempel D., van Haperen R., et al. Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines. J Clin Invest 2007, 117:616-626.
24. Ming X.F., Barandier C., Viswambharan H., et al. Thrombin stimulates human endothelial arginase enzymatic activity via rhoa/rock pathway: Implications for atherosclerotic endothelial dysfunction. Circulation 2004, 110:3708-3714.
25. Caro C.G., Fitz-Gerald J.M., Schroter R.C. Arterial wall shear and distribution of early atheroma in man. Nature 1969, 223:1159-1160.
26. Gallardo-Soler A., Gomez-Nieto C., Campo M.L., et al. Arginase i induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity. Mol Endocrinol 2008, 22:1394-1402.
27. Hayashi T., Esaki T., Sumi D., Mukherjee T., Iguchi A., Chaudhuri G. Modulating role of estradiol on arginase ii expression in hyperlipidemic rabbits as an atheroprotective mechanism. Proc Natl Acad Sci U S A 2006, 103:10485-10490.
28. Teupser D., Burkhardt R., Wilfert W., Haffner I., Nebendahl K., Thiery J. Identification of macrophage arginase i as a new candidate gene of atherosclerosis resistance. Arterioscler Thromb Vasc Biol 2006, 26:365-371.
29. Thomas A.C., Sala-Newby G.B., Ismail Y., Johnson J.L., Pasterkamp G., Newby A.C. Genomics of foam cells and nonfoamy macrophages from rabbits identifies arginase-i as a differential regulator of nitric oxide production. Arterioscler Thromb Vasc Biol 2007, 27:571-577.
30. Orr A.W., Sanders J.M., Bevard M., Coleman E., Sarembock I.J., Schwartz M.A. The subendothelial extracellular matrix modulates nf-kappab activation by flow: a potential role in atherosclerosis. J Cell Biol 2005, 169:191-202.
31. Munder M., Eichmann K., Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by cd4+ t cells correlates with th1/th2 phenotype. J Immunol 1998, 160:5347-5354.
32. Ganz P., Creager M.A., Fang J.C., et al. Pathogenic mechanisms of atherosclerosis: effect of lipid lowering on the biology of atherosclerosis. Am J Med 1996, 101. 4A10S-16S.
33. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
34. Khallou-Laschet J, Varthaman A, Fornasa G, et al. Macrophage plasticity in experimental atherosclerosis. PLoS One, 5:e8852.