Cucurbitane-type triterpenoids from the fruit pulp of momordica charantia

Natural Product Communications

Volumn 7, Issue 12, 2012, Pages 1575-1578

  Liao, Yun Wen ^a   Chen, Chiy Rong ^b   Kuo, Yueh Hsiung ^c   Hsu, Jue Liang ^a   Shih, Wen Ling ^a   Cheng, Hsueh Ling ^a   Huang, Tzou Chi ^a   Chang, Chi I ^a  

^a NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b NATIONAL TAITUNG UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cucurbitaceae; Cucurbitane; Fruit; Momordica charantia; Triterpenoid

Indexed keywords

5BETA 19 EPOXY 23 METHOXYCUCURBITA 6,24 DIEN 3BETA OL; 5BETA 19 EPOXY 23 METHOXYCUCURBITA 6,24 DIEN 3BETA OL 19 OLIDE; CYTOTOXIC AGENT; FLUOROURACIL; UNCLASSIFIED DRUG; 5BETA,19 EPOXY 23(R) METHOXYCUCURBITA 6,24 DIEN 3BETA OL; 5BETA,19-EPOXY-23(R)-METHOXYCUCURBITA-6,24-DIEN-3BETA-OL; COLORING AGENT; DITERPENE; PLANT EXTRACT; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; TRITERPENE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; FRUIT; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIVER CELL CARCINOMA; MOMORDICA CHARANTIA; PHYTOCHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; CELL SURVIVAL; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; INFRARED SPECTROPHOTOMETRY; ISOLATION AND PURIFICATION; MOMORDICA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORING AGENTS; DITERPENES; FRUIT; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOMORDICA; PLANT EXTRACTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; TETRAZOLIUM SALTS; THIAZOLES; TRITERPENES;

MLCS; MLOWN;

EID: 84875047606     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1200701207     Document Type: Article

References (26)

1. Wang X, Sun W, Cao J, Qu H, Bi X, Zhao Y. (2012) Structures of new triterpenoids and cytotoxicity activities of the isolated major compounds from the fruit of Momordica charantia L. Journal of Agricultural and Food Chemistry, 60, 3927-3933.
2. Rathi SS, Grover JK, Vats V. (2002) The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Phytotherapy Research, 16, 236-243.
3. Kobori M, Nakayama H, Fukushima K, Ohnishi-Kameyama M, Ono H, Fukushima T, Akimoto Y, Masumoto S, Yukizaki C, Hoshi Y. Deguchi T, Yoshida M. (2008) Bitter gourd suppresses lipopolysaccharide-induced inflammatory responses. Journal of Agricultural and Food Chemistry, 56, 4004-4011.
4. Harinantenaina L, Tanaka M, Takaoka S, Oda M, Mogami O, Uchida M, Asakawa Y. (2006) Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chemical & Pharmaceutical Bulletin, 54, 1017-1021.
5. Liu Y, Ali Z, Khan IA. (2008) Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia. Planta Medica, 74, 1291-1294.
6. Kimura Y, Akihisa T, Yuasa N, Ukiya M, Suzuki T, Toriyama M, Motohashi S, Tokuda H. (2005) Cucurbitane-type triterpenoids from the fruit of Momordica charantia. Journal of Natural Products, 68, 807-809.
7. Akihisa T, Higo N, Tokuda H, Ukiya M, Akazawa H, Tochigi Y, Kimura Y, Suzuki T, Nishino H. (2007) Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects. Journal of Natural Products, 70, 1233-1239.
8. Li QY, Chen HB, Liu ZM, Wang B, Zhao YY. (2007) Cucurbitane triterpenoids from Momordica charantia. Magnetic Resonance in Chemistry, 45, 451-456.
9. Matsuda H, Nakamura S, Murakami T, Yoshikawa M. (2007) Structures of new cucurbitane-type triterpenes and glycosides, karavilagenins D and E, and karavilosides VI, VII, VIII, IX, X, and XI, from the fruit of Momordica charantia. Heterocycles, 71, 331-341.
10. Nakamura S, Murakami T, Nakamura J, Kobayashi H, Matsuda H, Yoshikawa M. (2006) Structures of new cucurbitane-type triterpenes and glycosides, karavilagenins and karavilosides, from the dried fruit of Momordica charantia L. in Sri Lanka. Chemical & Pharmaceutical Bulletin, 54, 1545-1550.
11. Fatope MO, Takeda Y, Yamashita H, Okabe H, Yamauchi T. (1990) New cucurbitane triterpenoids from Momordica charantia. Journal of Natural Products, 53, 1491-1497.
12. Murakami T, Emoto A, Matsuda H, Yoshikawa M. (2001) Medicinal foodstuffs. XXI. Structures of new cucurbitane-type triterpene glycosides, goyaglycosides-a,-b,-c,-d,-e,-f,-g, and-h, and new oleanane-type triterpene saponins, goyasaponins I, II, and III, from the fresh fruit of Japanese Momordica charantia L. Chemical & Pharmaceutical Bulletin, 49, 54-63.
13. Begum S, Ahmed M, Siddiqui BS, Khan A, Saify ZS, Arif M. (1997) Triterpenes, a sterol and a monocyclic alcohol from Momordica charantia. Phytochemistry, 44, 1313-1320.
14. Miyahara Y, Okabe H, Yamauchi T. (1981) Studies on the constituents of Momordica charantia L. II. Isolation and characterization of minor seed glycosides, momordicosides C, D and E. Chemical & Pharmaceutical Bulletin, 29, 1561-1566.
15. Okabe H, Miyahara Y, Yamauchi T, Miyahara K, Kawasaki T. (1980) Studies on the constituents of Momordica charantia L. I. Isolation and characterization of momordicosides A and B, glycosides of a pentahydroxy-cucurbitane triterpene. Chemical & Pharmaceutical Bulletin, 28, 2753-2762.
16. Chen J, Tian R, Qiu M, Lu L, Zheng Y, Zhang Z. (2008) Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. Phytochemistry, 69, 1043-1048.
17. Yasuda M, Iwamoto M, Okabe H, Yamauchi T. (1984) Structures of momordicines I, II and III, the bitter principles in the leaves and vines of Momordica charantia L. Chemical & Pharmaceutical Bulletin, 32, 2044-2047.
18. Chen JC, Liu WQ, Lu L, Qiu MH, Zheng YT, Yang LM, Zhang XM, Zhou L, Li ZR. (2009) Kuguacins F-S, cucurbitane triterpenoids from Momordica charantia. Phytochemistry, 70, 133-140.
19. Chang CI, Chen CR, Liao YW, Cheng HL, Chen YC, Chou CH. (2006) Cucurbitane-type triterpenoids from Momordica charantia. Journal of Natural Products, 69, 1168-1171.
20. Chang CI, Chen CR, Liao YW, Cheng HL, Chen YC, Chou CH. (2008) Cucurbitane-type triterpenoids from the stems of Momordica charantia. Journal of Natural Products, 71, 1327-1330.
21. Chang CI, Chen CR, Liao YW, Shih WL, Cheng HL, Tzeng CY, Li JW, Kung MT. (2010) Octanorcucurbitane triterpenoids protect against t-BHP-induced hepatotoxicity from the stems of Momordica charantia. Chemical & Pharmaceutical Bulletin, 58, 225-229.
22. Chen CR, Liao YW, Shih WL, Tzeng CY, Chang CI. (2010) Triterpenoids from the stems of Momordica charantia. Helvetica Chimica Acta, 93, 1355-1361.
23. Chen CR, Liao YW, Wang L, Kuo YH, Liu HJ, Shih WL, Cheng HL, Chang CI. (2010) Cucurbitane triterpenoids from Momordica charantia and their cytoprotective activity in tert-butyl hydroperoxide-induced hepatotoxicity of HepG2 cells. Chemical & Pharmaceutical Bulletin, 58, 1639-1642.
24. Kim KG, Choi SU, Kim YC, Lee KR. (2011) Tirucallane triterpenoids from Cornus walteri. Journal of Natural Products, 74, 54-59.
25. Akihisa T, Higo N, Tokuda H, Ukiya M, Akazawa H, Tochigi Y, Kimura Y, Suzuki T, Nishino H. (2007) Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects. Journal of Natural Products, 70, 1233-1239.
26. Kuo YH, Li SY, Shen YC, Huang HC, Hsu YW, Tseng RJ, Ou JC, Chen CF. (2001) Sesquiterpene polyol esters and triterpenes from Celastrus punctatus. The Chinese Pharmaceutical Journal, 53, 257-268.