Comparison of terlipressin and noradrenalin on cerebral perfusion, intracranial pressure and cerebral extracellular concentrations of lactate and pyruvate in patients with acute liver failure in need of inotropic support

Journal of Hepatology

Volumn 47, Issue 3, 2007, Pages 381-386

  Eefsen, Martin ^a   Dethloff, Thomas ^a   Frederiksen, Hans Jorgen ^a   Hauerberg, John ^a   Hansen, Bent Adel ^a   Larsen, Fin Stolze ^a  

^a Rigshospitalet   (Denmark)

Author keywords

Acute liver failure; Ammonia; Arterial pressure; Autoregulation; Cerebral blood flow; Cerebral edema; Fulminant hepatic failure; Hepatic encephalopathy; Intracranial pressure; Lactate; Microdialysis; Pyruvate; Vasopressin

Indexed keywords

LACTIC ACID; NORADRENALIN; PYRUVIC ACID; TERLIPRESSIN;

ADOLESCENT; ADULT; ANALYTIC METHOD; ARTICLE; BRAIN PERFUSION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOPPLER ECHOGRAPHY; DRUG DOSE INCREASE; FEMALE; HUMAN; INFUSION; INOTROPISM; INTRACRANIAL PRESSURE; LIVER FAILURE; MALE; MICRODIALYSIS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; BRAIN; CEREBROVASCULAR CIRCULATION; EXTRACELLULAR FLUID; FEMALE; HUMANS; INTRACRANIAL PRESSURE; LACTIC ACID; LIVER FAILURE, ACUTE; LYSINE VASOPRESSIN; MALE; MICRODIALYSIS; MIDDLE AGED; NOREPINEPHRINE; OSMOLAR CONCENTRATION; PYRUVIC ACID; TREATMENT OUTCOME; VASOCONSTRICTOR AGENTS;

EID: 34547610773     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.04.015     Document Type: Article

References (26)

1. Clemmesen J.O., Galatius S., Skak C., Dalgaard P., Larsen F.S., and Ott P. The effect of increasing blood pressure with dopamine on systemic, splanchnic, and lower extremity hemodynamics in patients with acute liver failure. Scand J Gastroenterol 34 (1999) 921-927
2. Ware A.J., D'Agostino A.N., and Combes B. Cerebral edema: a major complication of massive hepatic necrosis. Gastroenterology 61 (1971) 877-884
3. Tofteng F., and Larsen F.S. The effect of indomethacin on intracranial pressure, cerebral perfusion and extracellular lactate and glutamate concentrations in patients with fulminant hepatic failure. J Cereb Blood Flow Metab 24 (2004) 798-804
4. Larsen F.S. Optimal management of patients with fulminant hepatic failure: targeting the brain. Hepatology 39 (2004) 299-301
5. Ellis A., and Wendon J. Circulatory, respiratory, cerebral, and renal derangements in acute liver failure: pathophysiology and management. Semin Liver Dis 16 (1996) 379-388
6. Landry D.W., and Oliver J.A. The pathogenesis of vasodilatory shock. N Engl J Med 345 (2001) 588-595
7. Larsen F.S., Ejlersen E., Hansen B.A., Knudsen G.M., Tygstrup N., and Secher N.H. Functional loss of cerebral blood flow autoregulation in patients with fulminant hepatic failure. J Hepatol 23 (1995) 212-217
8. Strauss G., Hansen B.A., Kirkegaard P., Rasmussen A., Hjortrup A., and Larsen F.S. Liver function, cerebral blood flow autoregulation, and hepatic encephalopathy in fulminant hepatic failure. Hepatology 25 (1997) 837-839
9. Jalan R., Olde Damink S.W., Deutz N.E., Hayes P.C., and Lee A. Restoration of cerebral blood flow autoregulation and reactivity to carbon dioxide in acute liver failure by moderate hypothermia. Hepatology 34 (2001) 50-54
10. Shawcross D.L., Davies N.A., Mookerjee R.P., Hayes P.C., Williams R., Lee A., et al. Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe encephalopathy. Hepatology 39 (2004) 471-475
11. 2-like receptors mediate cerebral blood flow increase following vasopressin administration in rats. J Cardiovasc Pharmacol 15 (1990) 579-585
12. Clemmesen J.O., Larsen F.S., Kondrup J., Hansen B.A., and Ott P. Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology 29 (1999) 648-653
13. Ferenci P., Lockwood A., Mullen K., Tarter R., Weissenborn K., and Blei A.T. Hepatic encephalopathy - definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 35 (2002) 716-721
14. Rosner M.J., Rosner S.D., and Johnson A.H. Cerebral perfusion pressure: management protocol and clinical results. J Neurosurg 83 (1995) 949-962
15. Hlatky R., Furuya Y., Valadka A.B., and Robertson C.S. Management of cerebral perfusion pressure. Semin Respir Crit Care Med 22 (2001) 3-12
16. Bhatia V., Singh R., and Acharya S.K. Predictive value of arterial ammonia for complications and outcome in acute liver failure. Gut 55 (2006) 98-104
17. Larsen F.S., and Wendon J. Brain edema in liver failure: basic physiologic principles and management. Liver Transpl 8 (2002) 983-989
18. Treschan T.A., and Peters J. The vasopressin system: physiology and clinical strategies. Anesthesiology 105 (2006) 599-612 quiz 639-40
19. Rolando N., Wade J., Davalos M., Wendon J., Philpott-Howard J., and Williams R. The systemic inflammatory response syndrome in acute liver failure. Hepatology 32 (2000) 734-739
20. Matok I., Vard A., Efrati O., Rubinshtein M., Vishne T., Leibovitch L., et al. Terlipressin as rescue therapy for intractable hypotension due to septic shock in children. Shock 23 (2005) 305-310
21. Bernal W., Donaldson N., Wyncoll D., and Wendon J. Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study. Lancet 359 (2002) 558-563
22. Schmidt L.E., and Larsen F.S. Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. Crit Care Med 34 (2006) 337-343
23. Chung C., Vaquero J., Gottstein J., and Blei A.T. Vasopressin accelerates experimental ammonia-induced brain edema in rats after portacaval anastomosis. J Hepatol 39 (2003) 193-199
24. Olpe H.R., and Steinmann M. Responses of locus coeruleus neurons to neuropeptides. Prog Brain Res 88 (1991) 241-248
25. Frokjaer V.G., Strauss G.I., Mehlsen J., Knudsen G.M., Rasmussen V., and Larsen F.S. Autonomic dysfunction and impaired cerebral autoregulation in cirrhosis. Clin Auton Res 16 (2006) 208-216
26. Strauss G., Hansen B.A., Knudsen G.M., and Larsen F.S. Hyperventilation restores cerebral blood flow autoregulation in patients with acute liver failure. J Hepatol 28 (1998) 199-203