Acitretin affects bioenergetics of liver mitochondria and promotes mitochondrial permeability transition: Potential mechanisms of hepatotoxicity

Toxicology

Volumn 306, Issue , 2013, Pages 93-100

  Silva, Filomena S G ^a,b   Ribeiro, Mariana P C ^a,b   Santos, Maria S ^a,c   Rocha Pereira, Petronila ^d,e   Santos Silva, Alice ^e,f   Custódio, José B A ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^e UNIVERSITY OF PORTO   (Portugal)

^f UNIVERSITY OF PORTO   (Portugal)

Author keywords

Acitretin; Adenine nucleotide translocase; Antiestrogens; Mitochondria; Mitochondrial permeability transition; Oxidative phosphorylation

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ETRETIN; HYDROXYTAMOXIFEN; RETINOID; TAMOXIFEN;

APOPTOSIS; ARTICLE; BIOENERGY; CONCENTRATION (PARAMETERS); LIVER MITOCHONDRION; LIVER TOXICITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ACITRETIN; ANIMALS; APOPTOSIS; ENERGY METABOLISM; LIVER; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; MITOCHONDRIAL ADP, ATP TRANSLOCASES; PHOSPHORYLATION; RATS; RATS, WISTAR; TAMOXIFEN;

EID: 84875021857     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.01.020     Document Type: Article

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