Intracellular RNA recognition pathway activates strong anti-viral response in human mast cells

Clinical and Experimental Immunology

Volumn 172, Issue 1, 2013, Pages 121-128

  Lappalainen, J ^a   Rintahaka, J ^b   Kovanen, P T ^a   Matikainen, S ^b   Eklund, K K ^a  

^a WIHURI RESEARCH INSTITUTE   (Finland)

^b FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

IL 29; Inflammation; Interferon; Mast cells; Virus

Indexed keywords

DOUBLE STRANDED RNA; INTERFERON; MYXOVIRUS RESISTANCE PROTEIN A; RETINOIC ACID INDUCIBLE PROTEIN I; TETRATRICOPEPTIDE REPEAT PROTEIN; TOLL LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; GENE; HUMAN; HUMAN CELL; MAST CELL; MELANOMA DIFFERENTIATION ASSOCIATED GENE 5; MOLECULAR RECOGNITION; PARAINFLUENZA VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENDAI VIRUS; UPREGULATION;

CELLS, CULTURED; DEAD-BOX RNA HELICASES; GENE EXPRESSION REGULATION; GTP-BINDING PROTEINS; HUMANS; INTERFERON INDUCERS; INTERFERONS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAST CELLS; POLY I-C; RECEPTORS, RETINOIC ACID; RNA, DOUBLE-STRANDED; SENDAI VIRUS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84874991151     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12042     Document Type: Article

References (42)

1. Galli SJ, Tsai M. Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. Eur J Immunol 2010; 40:1843-1851.
2. Abraham SN, St John AL. Mast cell-orchestrated immunity to pathogens. Nat Rev Immunol 2010; 10:440-452.
3. Metcalfe DD, Baram D, Mekori YA. Mast cells. Physiol Rev 1997; 77:1033-1079.
4. Malaviya R, Ikeda T, Ross E, Abraham SN. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature 1996; 381:77-80.
5. Marshall JS. Mast-cell responses to pathogens. Nat Rev Immunol 2004; 4:787-799.
6. Oksaharju A, Lappalainen J, Tuomainen AM etal. Pro-atherogenic lung and oral pathogens induce an inflammatory response in human and mouse mast cells. J Cell Mol Med 2009; 13:103-113.
7. Takeuchi O, Akira S. Recognition of viruses by innate immunity. Immunol Rev 2007; 220:214-224.
8. Takeuchi O, Akira S. MDA5/RIG-I and virus recognition. Curr Opin Immunol 2008; 20:17-22.
9. Nakhaei P, Genin P, Civas A, Hiscott J. RIG-I-like receptors: sensing and responding to RNA virus infection. Semin Immunol 2009; 21:215-222.
10. Yoneyama M, Fujita T. Function of RIG-I-like receptors in antiviral innate immunity. J Biol Chem 2007; 282:15315-15318.
11. Corne JM, Holgate ST. Mechanisms of virus induced exacerbations of asthma. Thorax 1997; 52:380-389.
12. Johnston SL. Influence of viral and bacterial respiratory infections on exacerbations and symptom severity in childhood asthma. Pediatr Pulmonol Suppl 1997; 16:88-89.
13. Dakhama A, Lee YM, Ohnishi H etal. Virus-specific IgE enhances airway responsiveness on reinfection with respiratory syncytial virus in newborn mice. J Allergy Clin Immunol 2009; 123:138-145.
14. Dakhama A, Park JW, Taube C etal. The role of virus-specific immunoglobulin E in airway hyperresponsiveness. Am J Respir Crit Care Med 2004; 170:952-959.
15. King CA, Anderson R, Marshall JS. Dengue virus selectively induces human mast cell chemokine production. J Virol 2002; 76:8408-8419.
16. Sugiyama K. Histamine release from rat mast cells induced by Sendai virus. Nature 1977; 270:614-615.
17. Fairweather D, Frisancho-Kiss S, Yusung SA etal. Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart. Am J Pathol 2004; 165:1883-1894.
18. Lappalainen J, Lindstedt KA, Kovanen PT. A protocol for generating high numbers of mature and functional human mast cells from peripheral blood. Clin Exp Allergy 2007; 37:1404-1414.
19. Pirhonen J, Sareneva T, Kurimoto M, Julkunen I, Matikainen S. Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway. J Immunol 1999; 162:7322-7329.
20. Taub D, Dastych J, Inamura N etal. Bone marrow-derived murine mast cells migrate, but do not degranulate, in response to chemokines. J Immunol 1995; 154:2393-2402.
21. Miettinen M, Sareneva T, Julkunen I, Matikainen S. IFNs activate Toll-like receptor gene expression in viral infections. Genes Immun 2001; 2:349-355.
22. Österlund P, Veckman V, Siren J etal. Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells. J Virol 2005; 79:9608-9617.
23. Saito T, Gale M, Jr. Principles of intracellular viral recognition. Curr Opin Immunol 2007; 19:17-23.
24. Marshall JS, King CA, McCurdy JD. Mast cell cytokine and chemokine responses to bacterial and viral infection. Curr Pharm Des 2003; 9:11-24.
25. Taub DD, Mikovits JA, Nilsson G etal. Alterations in mast cell function and survival following in vitro infection with human immunodeficiency viruses-1 through CXCR4. Cell Immunol 2004; 230:65-80.
26. Grunewald SM, Hahn C, Wohlleben G etal. Infection with influenza A virus leads to flu antigen-induced cutaneous anaphylaxis in mice. J Invest Dermatol 2002; 118:645-651.
27. Burke SM, Issekutz TB, Mohan K, Lee PW, Shmulevitz M, Marshall JS. Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism. Blood 2008; 111:5467-5476.
28. Kulka M, Alexopoulou L, Flavell RA, Metcalfe DD. Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3. J Allergy Clin Immunol 2004; 114:174-182.
29. Honda K, Takaoka A, Taniguchi T. Type I interferon gene induction by the interferon regulatory factor family of transcription factors. Immunity 2006; 25:349-360.
30. Pekarek V, Srinivas S, Eskdale J, Gallagher G. Interferon lambda-1 (IFN-lambda1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. Genes Immun 2007; 8:177-180.
31. Megjugorac NJ, Gallagher GE, Gallagher G. Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29). J Leukoc Biol 2009; 86:1359-1363.
32. Ziegler T, Matikainen S, Rönkkö E etal. Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells. J Virol 2005; 79:13800-13805.
33. Gautier G, Humbert M, Deauvieau F etal. A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med 2005; 201:1435-1446.
34. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ 1993; 307:982-986.
35. Miller EK, Hernandez JZ, Wimmenauer V etal. A mechanistic role for type III interferon-lambda1 in asthma exacerbations mediated by human rhinoviruses. Am J Respir Crit Care Med 2012; 185:508-516.
36. Wang Q, Miller DJ, Bowman ER etal. MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness. PLOS Pathog 2011; 7:e1002070.
37. Munz C, Lunemann JD, Getts MT, Miller SD. Antiviral immune responses: triggers of or triggered by autoimmunity? Nat Rev Immunol 2009; 9:246-258.
38. Badimon L, Storey RF, Vilahur G. Update on lipids, inflammation and atherothrombosis. Thromb Haemost 2011; 105:S34-42.
39. Siren J, Pirhonen J, Julkunen I, Matikainen S. IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29. J Immunol 2005; 174:1932-1937.
40. Tissari J, Siren J, Meri S, Julkunen I, Matikainen S. IFN-alpha enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression. J Immunol 2005; 174:4289-4294.
41. Siren J, Sareneva T, Pirhonen J etal. Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages. J Gen Virol 2004; 85:2357-2364.
42. Brown MG, McAlpine SM, Huang YY etal. RNA sensors enable human mast cell anti-viral chemokine production and IFN-mediated protection in response to antibody-enhanced dengue virus infection. PLOS ONE 2012; 7:e34055.