Enhanced liver progenitor cell survival and differentiation in vivo by spheroid implantation in a vascularized tissue engineering chamber

Biomaterials

Volumn 34, Issue 16, 2013, Pages 3992-4001

  Yap, Kiryu K ^a   Dingle, Aaron M ^a   Palmer, Jason A ^a,c   Dhillon, Raminder S ^a   Lokmic, Zerina ^a,b,e   Penington, Anthony J ^a,b,e   Yeoh, George C ^d   Morrison, Wayne A ^a,b,c   Mitchell, Geraldine M ^a,b,c  

^a O'Brien Institute   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c AUSTRALIAN CATHOLIC UNIVERSITY   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

Author keywords

Implanted cell survival and differentiation; Liver progenitor cells; Liver regeneration; Multicellular spheroid; Single cell suspension; Vascularized in vivo tissue engineering chamber

Indexed keywords

CELL SURVIVAL; IN-VIVO; LIVER REGENERATION; MULTICELLULAR SPHEROID; PROGENITOR CELL; SINGLE-CELL SUSPENSIONS;

CELL CULTURE; CELL DEATH; KERATIN; MAMMALS; THREE DIMENSIONAL; TISSUE;

TISSUE ENGINEERING;

BETA CATENIN; CASPASE 3; CYTOKERATIN 18; HEPATOCYTE NUCLEAR FACTOR 4ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY LABELING; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SUSPENSION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; IN VIVO STUDY; LIVER CELL; LIVER SURGERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPHEROID CELL; STEM CELL; TISSUE ENGINEERING; VASCULAR TISSUE;

ANIMALS; BLOOD VESSELS; CELL DIFFERENTIATION; CELL SURVIVAL; LIVER; MALE; MICE; MICE, SCID; SPHEROIDS, CELLULAR; STEM CELLS; SUSPENSIONS; TIME FACTORS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

MUS;

EID: 84874973534     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.02.011     Document Type: Article

References (33)

1. Dhawan A., Puppi J., Hughes R.D., Mitry R.R. Human hepatocyte transplantation: current experience and future challenges. Nat Rev Gastroenterol Hepatol 2010, 7(5):288-298.
2. Joseph B., Malhi H., Bhargava K.K., Palestro C.J., McCuskey R.S., Gupta S. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology 2002, 123(5):1677-1685.
3. Han B., Lu Y., Meng B., Qu B. Cellular loss after allogenic hepatocyte transplantation. Transplantation 2009, 87(1):1-5.
4. Ohashi K., Waugh J.M., Dake M.D., Yokoyama T., Kuge H., Nakajima Y., et al. Liver tissue engineering at extrahepatic sites in mice as a potential new therapy for genetic liver diseases. Hepatology 2005, 41(1):132-140.
5. Navarro-Alvarez N., Soto-Gutierrez A., Chen Y., Caballero-Corbalan J., Hassan W., Kobayashi S., et al. Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice. J Hepatol 2010, 52(2):211-219.
6. Cronin K.J., Messina A., Knight K.R., Cooper-White J.J., Stevens G.W., Penington A.J., et al. New murine model of spontaneous autologous tissue engineering, combining an arteriovenous pedicle with matrix materials. Plast Reconstr Surg 2004, 113(1):260-269.
7. Tilkorn D.J., Davies E.M., Keramidaris E., Dingle A.M., Gerrand Y.W., Taylor C.J., et al. The in vitro preconditioning of myoblasts to enhance subsequent survival in an in vivo tissue engineering chamber model. Biomaterials 2012, 33(15):3868-3879.
8. Lokmic Z., Mitchell G.M. Engineering the microcirculation. Tissue Eng Part B Rev 2008, 14(1):87-103.
9. Chen Y., Wong P.P., Sjeklocha L., Steer C.J., Sahin M.B. Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in culture. Hepatology 2012, 55(2):563-574.
10. Vinken M., Decrock E., Doktorova T., Ramboer E., De Vuyst E., Vanhaecke T., et al. Characterization of spontaneous cell death in monolayer cultures of primary hepatocytes. Arch Toxicol 2011, 85(12):1589-1596.
11. Dan Y.Y., Yeoh G.C. Liver stem cells: a scientific and clinical perspective. J Gastroenterol Hepatol 2008, 23(5):687-698.
12. Stachelscheid H., Urbaniak T., Ring A., Spengler B., Gerlach J.C., Zeilinger K. Isolation and characterization of adult human liver progenitors from ischemic liver tissue derived from therapeutic hepatectomies. Tissue Eng Part A 2009, 15(7):1633-1643.
13. Bhang S.H., Cho S.W., La W.G., Lee T.J., Yang H.S., Sun A.Y., et al. Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells. Biomaterials 2011, 32(11):2734-2747.
14. Lee W.Y., Wei H.J., Lin W.W., Yeh Y.C., Hwang S.M., Wang J.J., et al. Enhancement of cell retention and functional benefits in myocardial infarction using human amniotic-fluid stem-cell bodies enriched with endogenous ECM. Biomaterials 2011, 32(24):5558-5567.
15. Pampaloni F., Reynaud E.G., Stelzer E.H. The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 2007, 8(10):839-845.
16. Ota K., Saito S., Fujisawa K., Tanaka N. Xenotransplantation of spheroidal aggregate-cultured hepatocytes. Transplant Proc 1997, 29(1-2):912-913.
17. Tirnitz-Parker J.E., Tonkin J.N., Knight B., Olynyk J.K., Yeoh G.C. Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet. Int J Biochem Cell Biol 2007, 39(12):2226-2239.
18. Howard C.V., Reed M.G. Unbiased stereology 2005, BIOS Scientific Publishers, Oxford. 2nd ed.
19. Rophael J.A., Craft R.O., Palmer J.A., Hussey A.J., Thomas G.P., Morrison W.A., et al. Angiogenic growth factor synergism in a murine tissue engineering model of angiogenesis and adipogenesis. Am J Pathol 2007, 171(6):2048-2057.
20. Forster N., Palmer J.A., Yeoh G., Ong W.C., Mitchell G.M., Slavin J., et al. Expansion and hepatocytic differentiation of liver progenitor cells in vivo using a vascularized tissue engineering chamber in mice. Tissue Eng Part C Methods 2011, 17(3):359-366.
21. Brophy C.M., Luebke-Wheeler J.L., Amiot B.P., Khan H., Remmel R.P., Rinaldo P., et al. Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function. Hepatology 2009, 49(2):578-586.
22. Chinzei R., Tanaka Y., Shimizu-Saito K., Hara Y., Kakinuma S., Watanabe M., et al. Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology 2002, 36(1):22-29.
23. Tostoes R.M., Leite S.B., Serra M., Jensen J., Bjorquist P., Carrondo M.J., et al. Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing. Hepatology 2012, 55(4):1227-1236.
24. Helmlinger G., Yuan F., Dellian M., Jain R.K. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med 1997, 3(2):177-182.
25. Lin R.Z., Chang H.Y. Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol J 2008, 3(9-10):1172-1184.
26. Si-Tayeb K., Lemaigre F.P., Duncan S.A. Organogenesis and development of the liver. Dev Cell 2010, 18(2):175-189.
27. Monga S.P., Micsenyi A., Germinaro M., Apte U., Bell A. beta-Catenin regulation during matrigel-induced rat hepatocyte differentiation. Cell Tissue Res 2006, 323(1):71-79.
28. Kallis Y.N., Robson A.J., Fallowfield J.A., Thomas H.C., Alison M.R., Wright N.A., et al. Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response. Gut 2011, 60(4):525-533.
29. Zhu C., Coombe D.R., Zheng M.H., Yeoh G.C., Li L. Liver progenitor cell interactions with the extracellular matrix. J Tissue Eng Regen Med 2012.
30. Rountree C.B., Mishra L., Willenbring H. Stem cells in liver diseases and cancer: recent advances on the path to new therapies. Hepatology 2012, 55(1):298-306.
31. Micsenyi A., Tan X., Sneddon T., Luo J.H., Michalopoulos G.K., Monga S.P. Beta-catenin is temporally regulated during normal liver development. Gastroenterology 2004, 126(4):1134-1146.
32. Turner R.A., Wauthier E., Lozoya O., McClelland R., Bowsher J.E., Barbier C., et al. Successful transplantation of human hepatic stem cells with restricted localization to liver using hyaluronan grafts. Hepatology 2012 Sep 19, [Epub ahead of print]. 10.1002/hep.26065.
33. Furuyama K., Kawaguchi Y., Akiyama H., Horiguchi M., Kodama S., Kuhara T., et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet 2011, 43(1):34-41.