Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice

European Journal of Immunology

Volumn 43, Issue 3, 2013, Pages 770-778

  Kawano, Shinya ^a   Lin, Qingshun ^a   Amano, Hirofumi ^a   Kaneko, Toshiyuki ^a   Nishikawa, Keiko ^a   Tsurui, Hiromichi ^a   Tada, Norihiro ^a   Nishimura, Hiroyuki ^b   Takai, Toshiyuki ^c   Shirai, Toshikazu ^a   Takasaki, Yoshinari ^a   Hirose, Sachiko ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOIN UNIVERSITY OF YOKOHAMA   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Cytokines; Fc RIIB receptor; Rheumatoid arthritis; Systemic lupus erythematosus; Yaa mutation

Indexed keywords

AUTOANTIBODY; CD69 ANTIGEN; FC RECEPTOR IIB; INTERLEUKIN 10; INTERLEUKIN 21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE ACTIVATION; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; GENE; GENE MUTATION; HELPER CELL; MALE; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; UPREGULATION; Y CHROMOSOME LINKED AUTOIMMUNE ACCELERATION GENE;

ANIMALS; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CYTOKINES; DISEASE MODELS, ANIMAL; IMMUNOPHENOTYPING; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; PHENOTYPE; RECEPTORS, IGG; SPLEEN; SPLENOMEGALY; Y CHROMOSOME;

EID: 84874972047     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201243057     Document Type: Article

References (39)

1. Ravetch, J. V. and Kinet, J.-P., Fc receptors. Annu. Rev. Immunol. 1991. 9: 457-492.
2. Jiang, Y., Hirose, S., Abe, M., Sanokawa-Akakura, R., Ohtsuji, M., Mi, X., Li, N. et al., Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility. Immunogenetics 2000. 51: 429-435.
3. Jiang, Y., Hirose, S., Sanokawa-Akakura, R., Abe, M., Mi, X., Li, N., Miura, Y. et al., Genetically determined aberrant down-regulation of FcgRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus. Int. Immunol. 1999. 11: 1685-1691.
4. Xiu, Y., Nakamura, K., Abe, M., Li, N., Wen, X-S., Jiang, Y., Zhang, D. et al., Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. J. Immunol. 2002. 169: 4340-4346.
5. Lin, Q., Xiu, Y., Jiang, Y., Tsurui, H., Nakamura, K., Kodera, S., Ohtsuhi, M. et al., Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J. Immunol. 2006. 177: 1646-1654.
6. Sato-Hayashizaki, A., Ohtsuji, M., Lin, Q., Hou, R., Ohtsuji, N., Nishikawa, K., Tsurui, H. et al., Presumptive role of 129 strain-derived Sle16 locus for rheumatoid arthritis in a new mouse model with FcgRIIB-deficient C57BL/6 genetic background. Arthritis Rheum. 2011. 63: 2930-2938.
7. Carlucci, F., Cortes-Hernandez, J., Fossati-Jimack, L., Bygrave, A. E., walport, M. J., Vyse, T. J., Cook, H. T. et al., Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 loci when expressed on C57BL/6 mice. J. Immunol. 2007. 178: 2352-2360.
8. Boross, P., Arandhara, V. L., Martin-Ramirez, J., Santiago-Rober, M-L., Carlucci, F., Flierman, R., van der Kass, J. et al., The inhibiting Fc receptor for IgG, FcgRIIB, is a modifier of autoimmune susceptibility. J. Immunol. 2011. 187: 1304-1313.
9. Subramanian, S., Tus, K., Li, Q. Z., Wang, A., Tian, X. H., Zhou, J., Liang, C. et al., A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc. Natl. Acad. Sci. USA 2006. 103: 9970-9975.
10. Wandstrat, A. E., Nguyen, C., Limaye, N., Chan, A. Y., Subramanian, S., Tian, X.-H., Yim, Y.-S. et al., Association of extensive polymorphisms in the SLAM/CD20 gene cluster with murine lupus. Immunity 2004. 21: 769-780.
11. Jansson, L. and Holmdahl, R., The Y chromosome-linked "autoimmune accelerating" Yaa gene suppresses collagen-induced arthritis. Eur. J. Immunol. 1994. 24: 1213-1217.
12. Amano, H., Amano, E., Moll, T., Marinkovic, D., Ibnou-Zekri, N., Martinez-Soria, E., Semac, I. et al., The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells. J. Immunol. 2003. 170: 2293-2301.
13. Panush, R. S., Edwards, N. L., Longley, S. and Webster, E., 'Rhupus' syndrome. Arch. Intern. Med. 1988, 148: 1633-1636.
14. Jawaheer, D., Seldin, M. F., Amos, C. I., Chen, W. V., Shigeta, R., Monteio, J., Kern, M. et al., A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with autoimmune diseases. Am. J. Hum. Genet. 2001. 68: 927-936.
15. Pisitkunm, P., Deane, J. A., Difilippantonio, M. J., Tarasenko, T., Satterthwaite, A. B. and Bolland, S., Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 2006. 312: 1669-1672.
16. Deane, J. A., Pisitkun, P., Barrett, R. S., Feigenbaum, L., Town, T., Ward, J. M., Flavell, R. A. et al., Control of Toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007. 27: 801-810.
17. King, C., Tangye, S. G. and Mackay, C. R., T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu. Rev. Immunol. 2008. 26: 741-766.
18. Vinuesa, C. G., Sanz, I. and Cook, M. C., Dysregulation of germinal centers in autoimmune disease. Nat. Rev. Immunol. 2009. 9: 845-857.
19. King, C., A fine romance: T follicular helper cells and B cells. Immunity 2011. 34: 827-829.
20. Uysal, H., Nandakumar, K. S., Kessel, C., Carlsen, S., Burkhardt, H. and Holmdahl, R., Antibodies to citrullinated proteins: molecular interactions and arthritogenicity. Immunol. Rev. 2010. 133: 9-33.
21. López-Hoyos, M., Marquina, R., Tamayo, E., González-Rojas, J., Izui, S., Merino, R. and Merino, J., Defects in the regulation of B cell apoptosis are required for the production of citrullinated peptide autoantibodies in mice. Arthritis Rheum. 2003. 48: 2353-2361.
22. Spolski, R. and Leonard, W. J., Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 2008. 26: 57-79.
23. Bubier, J. A., Sproule, T. J., Foreman, O., Spolski, R., Shaffer, D. J., Morse, H. C. III, Leonard, W. J. et al., A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc. Natl. Acad. Sci. USA 2009. 106: 1518-1523.
24. lpr/lpr/J mice. J. Immunol. 2012. 188: 1656-1667.
25. Spolski, R., Kim, H.-R., Zhu, W., Levy, D. E. and Leonard, W. J., IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 2009. 182: 2859-2867.
26. Fiorentino, D. F., Bond, M. W. and Moamann, T. R., Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 1989. 170: 2081-2095.
27. Moore, K. W., de Waal Malefyt, R., Coffman, R. L. and O'Garra, A., Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001. 19: 683-765.
28. O'Garra, A., Barret, F. J., Castro, A. G., Vicari, A. and Hawrylowicz, C., Strategies for use of IL-10 or its antagonists in human disease. Immunol. Rev. 2008. 223: 114-131.
29. Hata, H., Sakaguchi, N., Yoshitomi, H., Iwakura, Y., Sekikawa, K., Azuma, Y., Kanai, C. et al., Distinct contribution of IL-6, TNF-a, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J. Clin. Invest. 2004. 114: 582-588.
30. Ishida, H., Muchamuel, T., Sakaguchi, S., Andrade, S., Menon, S. and Howard, M., Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice. J. Exp. Med. 1994. 179: 305-210.
31. Baechler, E. C., Batliwalla, F. M., Karypis, G., Gaffney, P. M., Ortmann, W. A., Espe, K. J., Shark, K. B. et al., Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc. Natl. Acad. Sci. USA 2003. 100: 2610-2615.
32. Bennett, L., Palucka, A. K., Arce, E., Cantrell, V., Borvak, J., Banchereau, J. and Pascual, V., Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J. Exp. Med. 2003. 197: 711-723.
33. Kirou, K. A., Lee, C., George, S., Louca, K., Papagiannis, I. G., Peterson, M. G., Ly, N. et al., Coordinate overexpression of interferon-a-induced genes in systemic lupus erythematosus. Arthritis Rheum. 2004. 50: 3958-3967.
34. Reeve, W. H., Lee, P. Y., Weinstein, J. S., Aatoh, M. and Lu, L., Induction of autoimmunity by pristine and other naturally occurring hydrocarbons. Trends in Immunol. 2009. 30: 455-464.
35. Ishihara, K. and Hirano, T., IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 2002. 13: 357-368.
36. Iwakura, Y., Nakae, S., Saijo, S. and Ishigame, H., The role of IL-17A in inflammatory immune responses and host defence against pathogens. Immunol. Rev. 2008. 226: 57-79.
37. Banchereau, J., Pascual, V. and Palucka, A. K., Autoimmunity through cytokine-induced dendritic cell activation. Immunity 2004. 20: 539-550.
38. Knight, J. G., Adams, D. D. and Purves, H. D., The genetic contribution of the NZB mouse to the renal disease of the NZB x NZW hybrid. Clin. Exp. Immunol. 1977. 28: 352-358.
39. Zhang, D., Fujio, K., Jiang, Y., Zhao, J., Tada, N., Sudo, K., Tsurui, H. et al., Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination. Proc. Natl. Acad. Sci. USA 2004. 101: 13838-13843.