Effect of intrahippocampal ghrelin agonist administration on passive avoidance learning and anxiety in rats

Pakistan Journal of Biological Sciences

Volumn 15, Issue 22, 2012, Pages 1063-1068

  Kajbaf, Forough ^a   Ahmadi, R ^a   Fatemi Tabatabaie, R ^b   Safarpoor, E ^a  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b SHAHID CHAMRAN UNIVERSITY OF AHVAZ   (Iran)

Author keywords

Alzheimer; Anxiety; Ghrelin agonist; Leaming; Ovariectomy

Indexed keywords

GHRELIN; GROWTH HORMONE-RELEASING PEPTIDE-2; OLIGOPEPTIDE; PRALMORELIN;

ANIMAL; ANIMAL BEHAVIOR; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; DRUG POTENTIATION; FEMALE; HIPPOCAMPAL CA1 REGION; METABOLISM; MOTOR ACTIVITY; OVARIECTOMY; PSYCHOLOGICAL ASPECT; RAT; WISTAR RAT;

ANIMALS; ANXIETY; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; CA1 REGION, HIPPOCAMPAL; FEMALE; GHRELIN; MOTOR ACTIVITY; OLIGOPEPTIDES; OVARIECTOMY; RATS; RATS, WISTAR;

EID: 84874962253     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2012.1063.1068     Document Type: Article

References (30)

1. Azman, A., B.A.K. Khalid and S. Ima-Nirwana, 2001. The effects of vitamine E on bodyweight and fat mass in the intact and ovariectomized female rats. Med. J. Islam. Acad. Sci., 14: 125-138.
2. Bernabeu, R., M.L. de Stein, C. Fin, I. Izquierdo and J.H. Medina, 1995. Role of hippocampal NO in the acquisition and consolidation of inhibitory avoidance learning. Neuroreport, 6: 1498-1500.
3. Berry, B., R. McMahan and M. Gallagher, 1997. Spatial learning and memory at defined points of the estrous cycle: Effects on performance of a hippocampal-dependent task. Behav. Neurosci., 111: 267-274.
4. Carlini, V.P., A.C. Martini, H.B. Schioth, R.D. Ruiz, M.F. de Cuneo and S.R. de Barioglio, 2008. Decreased memory for novel object recognition in chronically food-restricted mice is reversed by acute ghrelin administration. Neuroscience, 153: 929-934.
5. Carlini, V.P., M. Ghersi, H.B. Schioth and S.R. de Barioglio, 2010. Ghrelin and memory: Differential effects on acquisition and retrieval. Peptides, 31: 1190-1193.
6. Carlini, V.P., M.E. Monzon, M.M. Varas, A.B. Cragnolin, H.B. Schioth, T.N. Scimonelli and S.R. de Barioglio, 2002. Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem. Biophys. Res. Commun., 299: 739-743.
7. Carlini, V.P., M.F. Perez, E. Salde, H.B. Schioth, O.A. Ramirez and S.R. de Barioglio, 2010. Ghrelin induced memory facilitation implicates nitric oxide synthase activation and decrease in the threshold to promote LTP in hippocampal dentate gyrus. Physiol. Behav., 101: 117-123.
8. Carlini, V.P., M.M. Varas, A.B. Cragnolini, H.B. Schioth, T.N. Scimonelli and S.R. de Barioglio, 2004. Differential role of the hippocampus, amygdala and dorsal raphe nucleus in regulating feeding, memory and anxiety-like behavioral responses to ghrelin. Biochem. Biophys. Res. Commun., 313: 635-641.
9. Carlini, V.P., R.C. Gaydou, H.B. Schioth and S.R. de Barioglio, 2007. Selective serotonin reuptake inhibitor (fluoxetine) decreases the effects of ghrelin on memory retention and food intake. Regul. Pept., 140: 65-73.
10. Chen, H.I., L.C. Lin, L. Yu, Y.F. Liu and Y.M. Kuo et al., 2008. Treadmill exercise enhances passive avoidance learning in rats: The role of down-regulated serotonin system in the limbic system. Neurobiol. Learn. Memory, 89: 489-496.
11. Cottrell, G.T. and A.V. Ferguson, 2004. Sensory circumventricular organs: Central roles in integrated autonomic regulation. Regul. Pept., 117: 11-23.
12. Das, U.N., 2011. Relationship between gut and sepsis: Role of ghrelin. World J. Diabetes, 2: 1-7.
13. Ferrini, F., C. Salio, L. Lossi and A. Merighi, 2009. Ghrelin in central neurons. Curr. Neuropharmacol., 7: 37-49.
14. Furuta, S., O. Shimada, N. Doi, K. Ukai, T. Nakagawa, J. Watanabe and M. Imaizumi, 2004. General pharmacology of KP-102 (GHRP-2), a potent hrowth hormone-releasing peptide. Arzneimittelforschung, 54: 868-880.
15. Gould, E., C.S. Woolley, M. Frankfurt and B.S. McEwen, 1990. Gonadal steroids regulate dendritic spinedensity in hippocampal pyramidal cells inadulthood. J. Neurosci., 10: 1286-1291.
16. Gualillo, O., J.E. Caminos, M. Kojima, K. Kangawa and E. Arvat et al., 2001. Gender and gonadal influences on ghrelin mRNA levels in rat stomach. Eur. J. Endocrinol., 144: 687-690.
17. Hattori, N., T. Saito, T. Yagyu, B.H. Jiang, K. Kitagawa and C. Inagaki, 2001. GH, GH receptor, GH secretagogue receptor and ghrelin expression in human T cells, B cells and neutrophils. J. Clin. Endocrinol. Metab., 86: 4284-4291.
18. Himmerich, H. and A.J. Sheldrick, 2010. TNF-alpha and ghrelin: Opposite effects on immune system, metabolism and mental health. Protein Pept. Lett., 17: 186-196.
19. ICAC., 1995. Guide to the Care and Use of Experimental Animals. Vol. 1, Iranian Council of Animal Care, Iran.
20. Kojima, M., H. Hosoda, Y. Date, M. Nakazato, H. Matsuo and K. Kangawa, 1999. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402: 656-660.
21. Levinoff, E.L. and H. Chertkow, 2002. The biological and cognitive effects of estrogen on the aging brain. Drug Aging, 5: 41-44.
22. Magistrelli, D., L. Pinotti, L. Rapetti and F. Rosi, 2011. Ghrelin, insulin and pancreatic activity in the peri-weaning period of goat kids. J. Anim. Physiol. Anim. Nutr., 95: 40-46.
23. Mishkin, M., 1978. Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus. Nature, 273: 297-298.
24. Paxinos, G. and C. Watson, 1986. The Rat Brain in Stereotaxic Coordinates. 2nd Edn., Academic Press, San Diego, ISBN-10: 0125476213.
25. Sato, T., T. Teramoto, K. Tanaka, Y. Ohnishi, M. Irifune and T. Nishikawa, 2003. Effects of ovariectomy and calcium deficiency on learning and memory of eight-arm radial maze in middle-aged female rats. Behav. Brain Res., 142: 207-216.
26. Toth, K., K. Laszlo and L. Lenard, 2010. Role of intraamygdaloid acylated-ghrelin in spatial learning. Brain Res. Bull., 81: 33-37.
27. Toth, K., K. Laszlo, E. Lukacs and L. Lenard, 2009. Intraamygdaloid microinjection of acylated-ghrelin influences passive avoidance learning. Behav. Brain Res., 202: 308-311.
28. Toufexis, D.J., K.M. Myers and M. Davis, 2006. The effect of gonadal hormones and gender on anxiety and emotional learning. Horm. Behav., 50: 539-549.
29. Traebert, M., T. Riediger, S. Whitebread, E. Scharrer and H.A. Schmid, 2002. Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J. Neuroendocrinol., 14: 580-586.
30. Vazquez-Pereyra, F., S. Rivas-Arancibia, A.L.D. Castillo and S. Shcneider-Rivas, 1995. Modulation of short term and long term memory by steroid sexual hormones. Life Sci., 56: PL255-PL260.