Safe and effective use of a glycemic control protocol for neonates in a cardiac ICU

Pediatric Critical Care Medicine

Volumn 14, Issue 3, 2013, Pages 284-289

  Hebson, Camden L ^a   Chanani, Nikhil K ^a   Rigby, Mark R ^b   Wolf, Michael J ^a   Deshpande, Shriprasad R ^a   Montegna, Leticia M ^c   Maher, Kevin O ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Pharmacy Department   (United States)

Author keywords

congenital; critical illness; heart defects; hyperglycemia; infant; insulin; intensive care; newborn

Indexed keywords

GLUCOSE; INSULIN;

ARTICLE; BLOOD GLUCOSE MONITORING; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL PROTOCOL; CONGENITAL HEART DISEASE; CRITICALLY ILL PATIENT; DISEASE SEVERITY; DRUG DOSE TITRATION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEART SURGERY; HIGH RISK PATIENT; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN INFUSION; NEWBORN; NEWBORN INTENSIVE CARE; PATIENT SAFETY; PHYSICIAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT DURATION;

BIOLOGICAL MARKERS; BLOOD GLUCOSE; CLINICAL PROTOCOLS; CRITICAL ILLNESS; HEART DISEASES; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INFANT, NEWBORN; INSULIN; INTENSIVE CARE, NEONATAL; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84874944270     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e31827200de     Document Type: Article

References (39)

1. Finney SJ, Zekveld C, Elia A, et al: Glucose control and mortality in critically ill patients. JAMA 2003; 290:2041-2047
2. Krinsley JS: Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004; 79:992-1000
3. Hermans G, Wilmer A, Meersseman W, et al: Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit. Am J Respir Crit Care Med 2007; 175:480-489
4. Falciglia M: Causes and consequences of hyperglycemia in critical illness. Curr Opin Clin Nutr Metab Care 2007; 10:498-503
5. Laird AM, Miller PR, Kilgo PD, et al: Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 2004; 56:1058-1062
6. Capes SE, Hunt D, Malmberg K, et al: Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: A systematic overview. Lancet 2000; 355:773-778
7. Falcao G, Ulate K, Kouzekanani K, et al: Impact of postoperative hyperglycemia following surgical repair of congenital cardiac defects. Pediatr Cardiol 2008; 29:628-636
8. Faustino EV, Apkon M: Persistent hyperglycemia in critically ill children. J Pediatr 2005; 146:30-34
9. Piper HG, Alexander JL, Shukla A, et al: Real-time continuous glucose monitoring in pediatric patients during and after cardiac surgery. Pediatrics 2006; 118:1176-1184
10. Wintergerst KA, Buckingham B, Gandrud L, et al: Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics 2006; 118:173-179
11. Srinivasan V, Spinella PC, Drott HR, et al: Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med 2004; 5:329-336
12. Branco RG, Garcia PC, Piva JP, et al: Glucose level and risk of mortality in pediatric septic shock. Pediatr Crit Care Med 2005; 6:470-472
13. Klein GW, Hojsak JM, Schmeidler J, et al: Hyperglycemia and outcome in the pediatric intensive care unit. J Pediatr 2008; 153:379-384
14. Yung M, Wilkins B, Norton L, et al; Paediatric Study Group; Australian and New Zealand Intensive Care Society: Glucose control, organ failure, and mortality in pediatric intensive care. Pediatr Crit Care Med 2008; 9:147-152
15. Preissig CM, Rigby MR, Maher KO: Glycemic control for postoperative pediatric cardiac patients. Pediatr Cardiol 2009; 30:1098-1104
16. Preissig CM, Rigby MR: Pediatric critical illness hyperglycemia: Risk factors associated with development and severity of hyperglycemia in critically ill children. J Pediatr 2009; 155:734-739
17. Beardsall K, Vanhaesebrouck S, Ogilvy-Stuart AL, et al: Early insulin therapy in very-low-birth-weight infants. N Engl J Med 2008; 359:1873-1884
18. van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345:1359-1367
19. Van den Berghe G, Wilmer A, Hermans G, et al: Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354:449-461
20. Van den Berghe G, Wilmer A, Milants I, et al: Intensive insulin therapy in mixed medical/surgical intensive care units: Benefit versus harm. Diabetes 2006; 55:3151-3159
21. Vlasselaers D, Milants I, Desmet L, et al: Intensive insulin therapy for patients in paediatric intensive care: A prospective, randomised controlled study. Lancet 2009; 373:547-556
22. Finfer S, Chittock DR, Su SY, et al: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360(13):1283-1297
23. Brunkhorst FM, Engel C, Bloos F, et al; German Competence Network Sepsis (SepNet): Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358:125-139
24. Preiser JC, Devos P, Ruiz-Santana S, et al: A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: The Glucontrol study. Intensive Care Med 2009; 35:1738-1748
25. Moghissi ES, Korytkowski MT, DiNardo M, et al; American Association of Clinical Endocrinologists; American Diabetes Association: American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care 2009; 32:1119-1131
26. Preissig CM, Hansen I, Roerig PL, et al: A protocolized approach to identify and manage hyperglycemia in a pediatric critical care unit. Pediatr Crit Care Med 2008; 9:581-588
27. Doenst T, Bothe W, Beyersdorf F: Therapy with insulin in cardiac surgery: Controversies and possible solutions. Ann Thorac Surg 2003; 75:S721-S728
28. Taegtmeyer H: Energy metabolism of the heart: From basic concepts to clinical applications. Curr Probl Cardiol 1994; 19:59-113
29. Preissig CM, Rigby MR: Hyperglycaemia results from beta-cell dysfunction in critically ill children with respiratory and cardiovascular failure: A prospective observational study. Crit Care 2009; 13:R27
30. Vanhorebeek I, Ellger B, De Vos R, et al: Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness. Crit Care Med 2009; 37:1355-1364
31. Perner A, Nielsen SE, Rask-Madsen J: High glucose impairs superoxide production from isolated blood neutrophils. Intensive Care Med 2003; 29:642-645
32. Langouche L, Vanhorebeek I, Vlasselaers D, et al: Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 2005; 115:2277-2286
33. Vanhorebeek I, De Vos R, Mesotten D, et al: Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 2005; 365:53-59
34. Furnary AP, Zerr KJ, Grunkemeier GL, et al: Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg 1999; 67:352-60; discussion 360
35. Hansen TK, Thiel S, Wouters PJ, et al: Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 2003; 88:1082-1088
36. Leffler M, Hrach T, Stuerzl M, et al: Insulin attenuates apoptosis and exerts anti-inflammatory effects in endotoxemic human macrophages. J Surg Res 2007; 143:398-406
37. Hawdon JM, Weddell A, Aynsley-Green A, et al: Hormonal and metabolic response to hypoglycaemia in small for gestational age infants. Arch Dis Child 1993; 68(3 Spec No):269-273
38. Steil GM, Langer M, Jaeger K, et al: Value of continuous glucose monitoring for minimizing severe hypoglycemia during tight glycemic control. Pediatr Crit Care Med 2011; 12:643-648
39. Bridges BC, Preissig CM, Maher KO, et al: Continuous glucose monitors prove highly accurate in critically ill children. Crit Care 2010; 14:R176