Effects of crataegus microphylla on vascular dysfunction in streptozotocin-induced diabetic rats

Phytotherapy Research

Volumn 27, Issue 3, 2013, Pages 330-337

  Topal, Gökçe ^a   Koç, Ebru ^a   Karaca, Çetin ^b   Altuǧ, Tuncay ^c   Ergin, Bülent ^a   Demirci, Cihan ^a   Melikoǧlu, Gülay ^a   Meriçli, Ali H ^a   Kucur, Mine ^b   Özdemir, Osman ^d   Sonmez Uydes Dogan B ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c ISTANBUL BILIM UNIVERSITY   (Turkey)

^d CYPRUS INTERNATIONAL UNIVERSITY   (Turkey)

Author keywords

aorta; Crataegus microphylla; diabetes mellitus; rat; vascular dysfunction

Indexed keywords

ACETYLCHOLINE; ANTIDIABETIC AGENT; CRATAEGUS EXTRACT; CRATAEGUS MICROPHYLLA EXTRACT; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MALONALDEHYDE; NITRATE; NITRITE; NORADRENALIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CRATAEGUS; CRATAEGUS MICROPHYLLA; DIABETES MELLITUS; DRUG EFFECT; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIPID PEROXIDATION; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES; UPREGULATION; WEIGHT REDUCTION;

ANIMALS; AORTA; CRATAEGUS; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; INTERLEUKIN-6; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; NITRATES; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PLANT EXTRACTS; RATS; TUMOR NECROSIS FACTOR-ALPHA; VASODILATION; VASODILATOR AGENTS;

CRATAEGUS MICROPHYLLA; RATTUS;

EID: 84874935280     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4726     Document Type: Article

References (42)

1. Ajay M, Achike FI, Mustafa MR,. 2007. Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid. Pharmacol Res 55: 385-391. (Pubitemid 46560390)
2. Brown RA, Walsh MF, Ren J,. 2001. Influence of gender and diabetes on vascular and myocardial contractile function. Endocr Res 27 (4): 399-408. (Pubitemid 34042469)
3. Cai S, Khoo J, Alp NJ, Channon KM,. 2005. Endothelial nitric oxide synthase dysfunction in diabetic mice:importance of tetrahydrobiopterin in eNOS dimerisation. Diabetologia 48: 1933-1940. (Pubitemid 41317851)
4. Chen ZY, Zhang ZS, Kwan KY, Zhu M, Ho WK, Huang Y, 1998. Endothelium-dependent relaxation induced by hawthorn extract in rat mesenteric artery. Life Sci 63, 1983-1991. (Pubitemid 28522420)
5. Cheng X, Pang CC, 2004. Increased vasoconstriction to noradrenaline by 1400W, inhibitor of iNOS, in rats with streptozotocin-induced diabetes. Eur J Pharmacol 484, 263-268. (Pubitemid 38117219)
6. Coccheri S,. 2007. Approaches to prevention of cardiovascular complications and events in diabetes mellitus. Drugs 67: 997-1026. (Pubitemid 46744476)
7. Dalli E, Colomer E, Tormos MC, Cosin-Sales J, Milara J, Esteban E, Saez G,. 2011. Crataegus laevigata decreases neutrophil elastase and has hypolipidemic effect: A randomized, double-blind, placebo-controlled trial. Phytomedicine 18: 769-775.
8. Davì G, Falco A, Patrono C,. 2005. Lipid peroxidation in diabetes mellitus. Antioxid Redox Signal 7: 256-268. (Pubitemid 40187942)
9. Eguchi D, d' Uscio LV, Wambi C, et al,. 2002. Inhibitory effect of recombinant iNOS gene expression on vasomotor function of canine basilar artery. Am J Physiol 283: H2560-H2566. (Pubitemid 35345963)
10. Gunnett CA, Lund DD, Chu Y, Brooks RM 2nd., Faraci FM, Heistad DD,. 2001. NO-dependent vasorelaxation is impaired following gene transfer of inducible NO-synthase. Arterioscler Thromb Vasc Biol 21: 1281-1287. (Pubitemid 34219833)
11. Gunnett CA, Lund DD, Howard MA 3rd, Chu Y, Faraci FM, Heistad DD,. 2002. Gene transfer of inducible nitric oxide synthase impairs relaxation in human and rabbit cerebral arteries. Stroke 33: 2292-2296. (Pubitemid 35014645)
12. Gunnett CA, Heistad DD, Faraci FM,. 2003. Gene-targeted mice reveal a critical role for inducible nitric oxide synthase in vascular dysfunction during diabetes. Stroke 34: 2970-2974. (Pubitemid 37517779)
13. Han KA, Patel Y, Lteif AA, Chisholm R, Mather KJ,. 2011. Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium-dependent vasodilation in humans. Diabetes Metab Res Rev 27: 354-361.
14. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M,. 2001. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88: 14-22.
15. Hotamisligil GS, Spiegelman BM,. 1994. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 43: 1271-1278.
16. Ishikawa T, Kohno F, Kawase R, Yamamoto Y, Nakayama K,. 2004. Contribution of nitric oxide produced by inducible nitric oxide synthase to vascular responses of mesenteric arterioles in streptozotocin-diabetic rats. Br J Pharmacol 141: 269-276. (Pubitemid 38250897)
17. Kamper M, Tsimpoukidi O, Chatzigeorgiou A, Lymberi M, Kamper EF,. 2010. The antioxidant effect of angiotensin II receptor blocker, losartan, in streptozotocin-i.
18. Kim JH, Bachmann RA, Chen J,. 2009a. Interleukin-6 and insulin resistance. Vitam Horm 80: 613-633.
19. Kim HY, Okamoto T, Yokozawa T,. 2009b. Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats. J Ethnopharmacol 124: 263-269.
20. Kim SJ, Um JY, Lee JY,. 2011. Anti-inflammatory activity of hyperoside through the suppression of nuclear factor-kappaB activation in mouse peritoneal macrophages. Am J Chin Med 39: 171-181.
21. Kleinert H, Schwarz PM, Förstermann U,. 2003. Regulation of the expression of inducible nitric oxide synthase. Biol Chem 384 (10-11): 1343-64. (Pubitemid 37508640)
22. Leo CH, Joshi A, Woodman OL,. 2010. Short term type 1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery. Am J Physiol Heart Circ Physiol 299: H502-H511.
23. Madonna R, De Caterina R,. 2011. Cellular and molecular mechanisms of vascular injury in diabetes-Part 1: Pathways of vascular disease in diabetes. Vascul Pharmacol 54: 68-74.
24. Malakul W, Thirawarapan S, Ingkaninan K, Sawasdee P,. 2011. Effects of Kaempferia parviflora Wall. Ex Baker on endothelial dysfunction in streptozotocin-induced diabetic rats. J Ethnopharmacol 133: 371-377.
25. Matsumoto T, Noguchi E, Kobayashi T, Kamata K,. 2007. Mechanisms underlying the chronic pioglitazone treatment-induced improvement in the impaired endothelium-dependent relaxation seen in aortas from diabetic rats. Free Radic Biol Med 42: 993-1007. (Pubitemid 46356892)
26. Melikoglu G, Bitis L, Mericli AH,. 2004. Flavonoids of Crataegus microphylla. Nat Prod Res 18: 211-213. (Pubitemid 38584617)
27. Nagareddy PR, Xia Z, McNeill JH, MacLeod KM,. 2005. Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes. Am J Physiol Heart Circ Physiol 289: H2144-2152. (Pubitemid 41507367)
28. Ozcelikay AT, Tay A, Dincer D, Meral S, Yildizoglu-Ari N, Altan VM. 1999. The effects of chronic L-arginine treatment on vascular responsiveness of streptozotocin-diabetic rats. Gen Pharmacol 33: 299-306. (Pubitemid 29465735)
29. Ozturk N, Tuncel M,. 2011. Assessment of phenolic Acid content and in vitro antiradical characteristics of hawthorn. J Med Food 14: 664-669.
30. Pittler MH, Guo R, Ernst E,. 2008. Hawthorn extract for treating chronic heart failure. Cochrane Database Syst Rev 23 (1): CD005312.
31. Rains JL, Jain SK,. 2011. Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 50: 567-575.
32. Roghani M, Baluchnejadmojarad T,. 2009. Chronic epigallocatechin-gallate improves aortic reactivity of diabetic rats: underlying mechanisms. Vascul Pharmacol 51: 84-89.
33. Sönmez Uydeş-Doǧan B, Topal G, Takir S, Ilkay Alp F, Kaleli D, Ozdemir O,. 2005. Relaxant effects of pravastatin, atorvastatin and cerivastatin on isolated rat aortic rings. Life Sci 76 (15): 1771-86. (Pubitemid 40215219)
34. Soriano FG, Pacher P, Mabley J, Liaudet L, Szabo C,. 2001. Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res 89: 684-691. (Pubitemid 34627068)
35. Tadic VM, Dobric S, Markovic GM, et al,. 2008. Anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extract. J Agric Food Chem 56: 7700-7709.
36. Takahashi Y, Negoro M, Wakabayashi I,. 2003. Decreased modulation by lipopolysaccharide of aortic smooth muscle contractility in streptozotocin- induced hyperglycemic rats. J Cardiovasc Pharmacol 41: 162-170. (Pubitemid 36135239)
37. Takahashi Y, Nakano T, Wakabayashi I,. 2008. Increased induction of inducible nitric oxide synthase expression in aortae of type 2 diabetes rats. J Pharmacol Sci 107: 190-200. (Pubitemid 351931020)
38. Tian J, Yan Z, Wu Y, et al,. 2010. Inhibition of iNOS protects endothelial-dependent vasodilation in aged rats. Acta Pharmacol Sin 31: 1324-1328.
39. Vijayan NA, Thiruchenduran M, Devaraj SN,. 2012. Anti-inflammatory and anti-apoptotic effects of Crataegus oxyacantha on isoproterenol-induced myocardial damage. Mol Cell Biochem. [Epub ahead of print] DOI: 10.1007/s11010-012-1251-9
40. Walker AF, Marakis G, Simpson E, et al,. 2006. Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial. Br J Gen Pract 56: 437-443. (Pubitemid 43891226)
41. Wang S, Jiang JL, Hu CP, Zhang XJ, Yang DL, Li YJ,. 2007. Relationship between protective effects of rosiglitazone on endothelium and endogenous nitric oxide synthase inhibitor in streptozotocin-induced diabetic rats and cultured endothelial cells. Diabetes Metab Res Rev 23: 157-164.
42. Yamagishi S, Matsui T,. 2011. Nitric oxide, a janus-faced therapeutic target for diabetic microangiopathy-Friend or foe? Pharmacol Res 64: 187-194.