-
1
-
-
0024603895
-
Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity
-
D. Steinberg, S. Parthasarathy, T.E. Carew, J.C. Khoo, and J.L. Witztum Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity N. Engl. J. Med. 320 1989 915 924
-
(1989)
N. Engl. J. Med.
, vol.320
, pp. 915-924
-
-
Steinberg, D.1
Parthasarathy, S.2
Carew, T.E.3
Khoo, J.C.4
Witztum, J.L.5
-
2
-
-
0042170261
-
Cholesteryl ester oxidation products in atherosclerosis
-
N. Leitinger Cholesteryl ester oxidation products in atherosclerosis Mol. Aspects Med. 24 2003 239 250
-
(2003)
Mol. Aspects Med.
, vol.24
, pp. 239-250
-
-
Leitinger, N.1
-
3
-
-
67349268463
-
Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
-
A.J. Brown, and W. Jessup Oxysterols: sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis Mol. Aspects Med. 30 2009 111 122
-
(2009)
Mol. Aspects Med.
, vol.30
, pp. 111-122
-
-
Brown, A.J.1
Jessup, W.2
-
4
-
-
0000892775
-
Ozonization of cholesterol
-
J. Gumulka, and L.L. Smith Ozonization of cholesterol J. Am. Chem. Soc. 105 1983 1972 1979
-
(1983)
J. Am. Chem. Soc.
, vol.105
, pp. 1972-1979
-
-
Gumulka, J.1
Smith, L.L.2
-
5
-
-
0011972023
-
Ozonization of cholesterol in nonparticipating solvents
-
K. Jaworski, and L.L. Smith Ozonization of cholesterol in nonparticipating solvents J. Org. Chem. 53 1988 545 554
-
(1988)
J. Org. Chem.
, vol.53
, pp. 545-554
-
-
Jaworski, K.1
Smith, L.L.2
-
6
-
-
37049089535
-
The reaction of cholesterol with ozone and alcohols: A revised mechanism and structure of the principal product
-
Z. Paryzek, J. Martynow, and W. Swoboda The reaction of cholesterol with ozone and alcohols: a revised mechanism and structure of the principal product J. Chem. Soc. Perkin Trans 1 1990 1222 1223
-
(1990)
J. Chem. Soc. Perkin Trans
, vol.1
, pp. 1222-1223
-
-
Paryzek, Z.1
Martynow, J.2
Swoboda, W.3
-
7
-
-
0242662455
-
Evidence for ozone formation in human atherosclerotic arteries
-
P.J. Wentworth, J. Nieva, C. Takeuchi, R. Galve, A.D. Wentworth, R.B. Dilley, G.A. DeLaria, A. Saven, B.M. Babior, K.D. Janda, A. Eschenmoser, and R.A. Lerner Evidence for ozone formation in human atherosclerotic arteries Science 302 2003 1053 1056
-
(2003)
Science
, vol.302
, pp. 1053-1056
-
-
Wentworth, P.J.1
Nieva, J.2
Takeuchi, C.3
Galve, R.4
Wentworth, A.D.5
Dilley, R.B.6
Delaria, G.A.7
Saven, A.8
Babior, B.M.9
Janda, K.D.10
Eschenmoser, A.11
Lerner, R.A.12
-
8
-
-
33749824176
-
Small molecule oxidation products trigger disease-associated protein misfolding
-
J. Bieschke, Q. Zhang, D.A. Bosco, R.A. Lerner, E.T. Powers, P.J. Wentworth, and J.W. Kelly Small molecule oxidation products trigger disease-associated protein misfolding Acc. Chem. Res. 39 2006 611 619
-
(2006)
Acc. Chem. Res.
, vol.39
, pp. 611-619
-
-
Bieschke, J.1
Zhang, Q.2
Bosco, D.A.3
Lerner, R.A.4
Powers, E.T.5
Wentworth, P.J.6
Kelly, J.W.7
-
9
-
-
33646451063
-
Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization
-
D.A. Bosco, D.M. Fowler, Q. Zhang, J. Nieva, E.T. Powers, P.J. Wentworth, R.A. Lerner, and J.W. Kelly Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization Nat. Chem. Biol. 2 2006 249 253
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 249-253
-
-
Bosco, D.A.1
Fowler, D.M.2
Zhang, Q.3
Nieva, J.4
Powers, E.T.5
Wentworth, P.J.6
Lerner, R.A.7
Kelly, J.W.8
-
10
-
-
27744533917
-
A major ozonation product of cholesterol, 3β-hydroxy-5-oxo-5,6- secocholestan-6-al, induces apoptosis in H9c2 cardiomyoblasts
-
K. Sathishkumar, M. Haque, T.E. Perumal, J. Francis, and R.M. Uppu A major ozonation product of cholesterol, 3β-hydroxy-5-oxo-5,6-secocholestan- 6-al, induces apoptosis in H9c2 cardiomyoblasts FEBS Lett. 579 2005 6444 6450
-
(2005)
FEBS Lett.
, vol.579
, pp. 6444-6450
-
-
Sathishkumar, K.1
Haque, M.2
Perumal, T.E.3
Francis, J.4
Uppu, R.M.5
-
11
-
-
33845384842
-
Cytotoxic effects of oxysterols produced during ozonolysis of cholesterol in murine GT1-7 hypothalamic neurons
-
K. Sathishkumar, S.N. Murthy, and R.M. Uppu Cytotoxic effects of oxysterols produced during ozonolysis of cholesterol in murine GT1-7 hypothalamic neurons Free Radic. Res. 41 2007 82 88
-
(2007)
Free Radic. Res.
, vol.41
, pp. 82-88
-
-
Sathishkumar, K.1
Murthy, S.N.2
Uppu, R.M.3
-
12
-
-
67650738529
-
Cholesterol secoaldehyde induces apoptosis in H9c2 cardiomyoblasts through reactive oxygen species involving mitochondrial and death receptor pathways
-
K. Sathishkumar, X. Gao, A.C. Raghavamenon, N. Parinandi, W.A. Pryor, and R.M. Uppu Cholesterol secoaldehyde induces apoptosis in H9c2 cardiomyoblasts through reactive oxygen species involving mitochondrial and death receptor pathways Free Radic. Biol. Med. 47 2009 548 558
-
(2009)
Free Radic. Biol. Med.
, vol.47
, pp. 548-558
-
-
Sathishkumar, K.1
Gao, X.2
Raghavamenon, A.C.3
Parinandi, N.4
Pryor, W.A.5
Uppu, R.M.6
-
13
-
-
11144353774
-
Metabolite-initiated protein misfolding may trigger Alzheimer's disease
-
Q. Zhang, E.T. Powers, J. Nieva, M.E. Huff, M.A. Dendle, J. Bieschke, C.G. Glabe, A. Eschenmoser, P.J. Wentworth, R.A. Lerner, and J.W. Kelly Metabolite-initiated protein misfolding may trigger Alzheimer's disease Proc. Natl. Acad. Sci. USA 101 2004 4752 4757
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4752-4757
-
-
Zhang, Q.1
Powers, E.T.2
Nieva, J.3
Huff, M.E.4
Dendle, M.A.5
Bieschke, J.6
Glabe, C.G.7
Eschenmoser, A.8
Wentworth, P.J.9
Lerner, R.A.10
Kelly, J.W.11
-
14
-
-
16344385440
-
Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation
-
J. Bieschke, Q. Zhang, E.T. Powers, R.A. Lerner, and J.W. Kelly Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation Biochemistry 44 2005 4977 4983
-
(2005)
Biochemistry
, vol.44
, pp. 4977-4983
-
-
Bieschke, J.1
Zhang, Q.2
Powers, E.T.3
Lerner, R.A.4
Kelly, J.W.5
-
15
-
-
79960931701
-
Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53
-
J. Nieva, B.D. Song, J.K. Rogel, D. Kujawara, L. Altobel, A. Izharrudin, G.E. Boldt, R.K. Grover, A.D. Wentworth, and P.J. Wentworth Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53 Chem. Biol. 18 2011 920 927
-
(2011)
Chem. Biol.
, vol.18
, pp. 920-927
-
-
Nieva, J.1
Song, B.D.2
Rogel, J.K.3
Kujawara, D.4
Altobel, L.5
Izharrudin, A.6
Boldt, G.E.7
Grover, R.K.8
Wentworth, A.D.9
Wentworth, P.J.10
-
16
-
-
78650864074
-
Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway
-
S. Tomono, N. Miyoshi, H. Shiokawa, T. Iwabuchi, Y. Aratani, T. Higashi, H. Nukaya, and H. Ohshima Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway J. Lipid Res. 52 2011 87 97
-
(2011)
J. Lipid Res.
, vol.52
, pp. 87-97
-
-
Tomono, S.1
Miyoshi, N.2
Shiokawa, H.3
Iwabuchi, T.4
Aratani, Y.5
Higashi, T.6
Nukaya, H.7
Ohshima, H.8
-
17
-
-
84855369763
-
Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases
-
Y.L. Lai, S. Tomono, N. Miyoshi, and H. Ohshima Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: implications for vascular and neurodegenerative diseases J. Clin. Biochem. Nutr. 50 2012 84 89
-
(2012)
J. Clin. Biochem. Nutr.
, vol.50
, pp. 84-89
-
-
Lai, Y.L.1
Tomono, S.2
Miyoshi, N.3
Ohshima, H.4
-
18
-
-
0020539888
-
Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency
-
J. Siedel, E.O. Hägele, J. Ziegenhorn, and A.W. Wahlefeld Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency Clin. Chem. 29 1983 1075 1080
-
(1983)
Clin. Chem.
, vol.29
, pp. 1075-1080
-
-
Siedel, J.1
Hägele, E.O.2
Ziegenhorn, J.3
Wahlefeld, A.W.4
-
19
-
-
80052355323
-
A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine
-
S. Tomono, N. Miyoshi, M. Ito, T. Higashi, and H. Ohshima A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine J. Chromatogr. B Anal. Technol. Biomed. Life Sci 879 2011 2802 2808
-
(2011)
J. Chromatogr. B Anal. Technol. Biomed. Life Sci
, vol.879
, pp. 2802-2808
-
-
Tomono, S.1
Miyoshi, N.2
Ito, M.3
Higashi, T.4
Ohshima, H.5
-
20
-
-
0038080095
-
Covalent binding of oxidized cholesteryl esters to protein: Implications for oxidative modification of low density lipoprotein and atherosclerosis
-
Y. Kawai, A. Saito, N. Shibata, M. Kobayashi, S. Yamada, T. Osawa, and K. Uchida Covalent binding of oxidized cholesteryl esters to protein: implications for oxidative modification of low density lipoprotein and atherosclerosis J. Biol. Chem. 278 2003 21040 21049
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 21040-21049
-
-
Kawai, Y.1
Saito, A.2
Shibata, N.3
Kobayashi, M.4
Yamada, S.5
Osawa, T.6
Uchida, K.7
-
22
-
-
51949112126
-
Hock cleavage of cholesterol 5α-hydroperoxide: An ozone-free pathway to the cholesterol ozonolysis products identified in arterial plaque and brain tissue
-
J. Brinkhorst, S.J. Nara, and D.A. Pratt Hock cleavage of cholesterol 5α-hydroperoxide: an ozone-free pathway to the cholesterol ozonolysis products identified in arterial plaque and brain tissue J. Am. Chem. Soc 130 2008 12224 12225
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 12224-12225
-
-
Brinkhorst, J.1
Nara, S.J.2
Pratt, D.A.3
-
24
-
-
65949089029
-
The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo
-
A.D. Wentworth, B.D. Song, J. Nieva, A. Shafton, S. Tripurenani, and P.J. Wentworth The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo Chem. Commun. (Cambridge) 21 2009 3098 3100
-
(2009)
Chem. Commun. (Cambridge)
, vol.21
, pp. 3098-3100
-
-
Wentworth, A.D.1
Song, B.D.2
Nieva, J.3
Shafton, A.4
Tripurenani, S.5
Wentworth, P.J.6
-
25
-
-
33745051110
-
Proatherogenic effects of the cholesterol ozonolysis products, atheronal-A and atheronal-B
-
C. Takeuchi, R. Galve, J. Nieva, D.P. Witter, A.D. Wentworth, R.P. Troseth, R.A. Lerner, and P.J. Wentworth Proatherogenic effects of the cholesterol ozonolysis products, atheronal-A and atheronal-B Biochemistry 45 2006 7162 7170
-
(2006)
Biochemistry
, vol.45
, pp. 7162-7170
-
-
Takeuchi, C.1
Galve, R.2
Nieva, J.3
Witter, D.P.4
Wentworth, A.D.5
Troseth, R.P.6
Lerner, R.A.7
Wentworth, P.J.8
-
26
-
-
34248220035
-
Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation
-
C.R. Stewart, L.M. Wilson, Q. Zhang, C.L. Pham, L.J. Waddington, M.K. Staples, D. Stapleton, J.W. Kelly, and G.J. Howlett Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation Biochemistry 46 2007 5552 5561
-
(2007)
Biochemistry
, vol.46
, pp. 5552-5561
-
-
Stewart, C.R.1
Wilson, L.M.2
Zhang, Q.3
Pham, C.L.4
Waddington, L.J.5
Staples, M.K.6
Stapleton, D.7
Kelly, J.W.8
Howlett, G.J.9
-
27
-
-
47649090153
-
Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation
-
J. Nieva, A. Shafton, L.J. Altobell, S. Tripuraneni, J.K. Rogel, A.D. Wentworth, R.A. Lerner, and P.J. Wentworth Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation Biochemistry 47 2008 7695 7705
-
(2008)
Biochemistry
, vol.47
, pp. 7695-7705
-
-
Nieva, J.1
Shafton, A.2
Altobell, L.J.3
Tripuraneni, S.4
Rogel, J.K.5
Wentworth, A.D.6
Lerner, R.A.7
Wentworth, P.J.8
-
28
-
-
79952963272
-
Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope
-
N.K. Cygan, J.C. Scheinost, T.D. Butters, and P.J. Wentworth Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope Biochemistry 50 2011 2092 2100
-
(2011)
Biochemistry
, vol.50
, pp. 2092-2100
-
-
Cygan, N.K.1
Scheinost, J.C.2
Butters, T.D.3
Wentworth, P.J.4
|