메뉴 건너뛰기




Volumn 60, Issue , 2013, Pages 73-79

Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low-density lipoprotein

Author keywords

Cholesteryl ester; Cytotoxicity; Free radicals; LC ESI MS MS; LDL; Secosterol

Indexed keywords

ALDEHYDE DERIVATIVE; CHOLESTEROL ESTER; LOW DENSITY LIPOPROTEIN;

EID: 84874932236     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.01.029     Document Type: Article
Times cited : (19)

References (29)
  • 1
    • 0024603895 scopus 로고
    • Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity
    • D. Steinberg, S. Parthasarathy, T.E. Carew, J.C. Khoo, and J.L. Witztum Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity N. Engl. J. Med. 320 1989 915 924
    • (1989) N. Engl. J. Med. , vol.320 , pp. 915-924
    • Steinberg, D.1    Parthasarathy, S.2    Carew, T.E.3    Khoo, J.C.4    Witztum, J.L.5
  • 2
    • 0042170261 scopus 로고    scopus 로고
    • Cholesteryl ester oxidation products in atherosclerosis
    • N. Leitinger Cholesteryl ester oxidation products in atherosclerosis Mol. Aspects Med. 24 2003 239 250
    • (2003) Mol. Aspects Med. , vol.24 , pp. 239-250
    • Leitinger, N.1
  • 3
    • 67349268463 scopus 로고    scopus 로고
    • Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
    • A.J. Brown, and W. Jessup Oxysterols: sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis Mol. Aspects Med. 30 2009 111 122
    • (2009) Mol. Aspects Med. , vol.30 , pp. 111-122
    • Brown, A.J.1    Jessup, W.2
  • 4
    • 0000892775 scopus 로고
    • Ozonization of cholesterol
    • J. Gumulka, and L.L. Smith Ozonization of cholesterol J. Am. Chem. Soc. 105 1983 1972 1979
    • (1983) J. Am. Chem. Soc. , vol.105 , pp. 1972-1979
    • Gumulka, J.1    Smith, L.L.2
  • 5
    • 0011972023 scopus 로고
    • Ozonization of cholesterol in nonparticipating solvents
    • K. Jaworski, and L.L. Smith Ozonization of cholesterol in nonparticipating solvents J. Org. Chem. 53 1988 545 554
    • (1988) J. Org. Chem. , vol.53 , pp. 545-554
    • Jaworski, K.1    Smith, L.L.2
  • 6
    • 37049089535 scopus 로고
    • The reaction of cholesterol with ozone and alcohols: A revised mechanism and structure of the principal product
    • Z. Paryzek, J. Martynow, and W. Swoboda The reaction of cholesterol with ozone and alcohols: a revised mechanism and structure of the principal product J. Chem. Soc. Perkin Trans 1 1990 1222 1223
    • (1990) J. Chem. Soc. Perkin Trans , vol.1 , pp. 1222-1223
    • Paryzek, Z.1    Martynow, J.2    Swoboda, W.3
  • 9
  • 10
    • 27744533917 scopus 로고    scopus 로고
    • A major ozonation product of cholesterol, 3β-hydroxy-5-oxo-5,6- secocholestan-6-al, induces apoptosis in H9c2 cardiomyoblasts
    • K. Sathishkumar, M. Haque, T.E. Perumal, J. Francis, and R.M. Uppu A major ozonation product of cholesterol, 3β-hydroxy-5-oxo-5,6-secocholestan- 6-al, induces apoptosis in H9c2 cardiomyoblasts FEBS Lett. 579 2005 6444 6450
    • (2005) FEBS Lett. , vol.579 , pp. 6444-6450
    • Sathishkumar, K.1    Haque, M.2    Perumal, T.E.3    Francis, J.4    Uppu, R.M.5
  • 11
    • 33845384842 scopus 로고    scopus 로고
    • Cytotoxic effects of oxysterols produced during ozonolysis of cholesterol in murine GT1-7 hypothalamic neurons
    • K. Sathishkumar, S.N. Murthy, and R.M. Uppu Cytotoxic effects of oxysterols produced during ozonolysis of cholesterol in murine GT1-7 hypothalamic neurons Free Radic. Res. 41 2007 82 88
    • (2007) Free Radic. Res. , vol.41 , pp. 82-88
    • Sathishkumar, K.1    Murthy, S.N.2    Uppu, R.M.3
  • 12
    • 67650738529 scopus 로고    scopus 로고
    • Cholesterol secoaldehyde induces apoptosis in H9c2 cardiomyoblasts through reactive oxygen species involving mitochondrial and death receptor pathways
    • K. Sathishkumar, X. Gao, A.C. Raghavamenon, N. Parinandi, W.A. Pryor, and R.M. Uppu Cholesterol secoaldehyde induces apoptosis in H9c2 cardiomyoblasts through reactive oxygen species involving mitochondrial and death receptor pathways Free Radic. Biol. Med. 47 2009 548 558
    • (2009) Free Radic. Biol. Med. , vol.47 , pp. 548-558
    • Sathishkumar, K.1    Gao, X.2    Raghavamenon, A.C.3    Parinandi, N.4    Pryor, W.A.5    Uppu, R.M.6
  • 14
    • 16344385440 scopus 로고    scopus 로고
    • Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation
    • J. Bieschke, Q. Zhang, E.T. Powers, R.A. Lerner, and J.W. Kelly Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation Biochemistry 44 2005 4977 4983
    • (2005) Biochemistry , vol.44 , pp. 4977-4983
    • Bieschke, J.1    Zhang, Q.2    Powers, E.T.3    Lerner, R.A.4    Kelly, J.W.5
  • 17
    • 84855369763 scopus 로고    scopus 로고
    • Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases
    • Y.L. Lai, S. Tomono, N. Miyoshi, and H. Ohshima Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: implications for vascular and neurodegenerative diseases J. Clin. Biochem. Nutr. 50 2012 84 89
    • (2012) J. Clin. Biochem. Nutr. , vol.50 , pp. 84-89
    • Lai, Y.L.1    Tomono, S.2    Miyoshi, N.3    Ohshima, H.4
  • 18
    • 0020539888 scopus 로고
    • Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency
    • J. Siedel, E.O. Hägele, J. Ziegenhorn, and A.W. Wahlefeld Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency Clin. Chem. 29 1983 1075 1080
    • (1983) Clin. Chem. , vol.29 , pp. 1075-1080
    • Siedel, J.1    Hägele, E.O.2    Ziegenhorn, J.3    Wahlefeld, A.W.4
  • 19
    • 80052355323 scopus 로고    scopus 로고
    • A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine
    • S. Tomono, N. Miyoshi, M. Ito, T. Higashi, and H. Ohshima A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine J. Chromatogr. B Anal. Technol. Biomed. Life Sci 879 2011 2802 2808
    • (2011) J. Chromatogr. B Anal. Technol. Biomed. Life Sci , vol.879 , pp. 2802-2808
    • Tomono, S.1    Miyoshi, N.2    Ito, M.3    Higashi, T.4    Ohshima, H.5
  • 20
    • 0038080095 scopus 로고    scopus 로고
    • Covalent binding of oxidized cholesteryl esters to protein: Implications for oxidative modification of low density lipoprotein and atherosclerosis
    • Y. Kawai, A. Saito, N. Shibata, M. Kobayashi, S. Yamada, T. Osawa, and K. Uchida Covalent binding of oxidized cholesteryl esters to protein: implications for oxidative modification of low density lipoprotein and atherosclerosis J. Biol. Chem. 278 2003 21040 21049
    • (2003) J. Biol. Chem. , vol.278 , pp. 21040-21049
    • Kawai, Y.1    Saito, A.2    Shibata, N.3    Kobayashi, M.4    Yamada, S.5    Osawa, T.6    Uchida, K.7
  • 22
    • 51949112126 scopus 로고    scopus 로고
    • Hock cleavage of cholesterol 5α-hydroperoxide: An ozone-free pathway to the cholesterol ozonolysis products identified in arterial plaque and brain tissue
    • J. Brinkhorst, S.J. Nara, and D.A. Pratt Hock cleavage of cholesterol 5α-hydroperoxide: an ozone-free pathway to the cholesterol ozonolysis products identified in arterial plaque and brain tissue J. Am. Chem. Soc 130 2008 12224 12225
    • (2008) J. Am. Chem. Soc , vol.130 , pp. 12224-12225
    • Brinkhorst, J.1    Nara, S.J.2    Pratt, D.A.3
  • 24
    • 65949089029 scopus 로고    scopus 로고
    • The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo
    • A.D. Wentworth, B.D. Song, J. Nieva, A. Shafton, S. Tripurenani, and P.J. Wentworth The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo Chem. Commun. (Cambridge) 21 2009 3098 3100
    • (2009) Chem. Commun. (Cambridge) , vol.21 , pp. 3098-3100
    • Wentworth, A.D.1    Song, B.D.2    Nieva, J.3    Shafton, A.4    Tripurenani, S.5    Wentworth, P.J.6
  • 28
    • 79952963272 scopus 로고    scopus 로고
    • Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope
    • N.K. Cygan, J.C. Scheinost, T.D. Butters, and P.J. Wentworth Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope Biochemistry 50 2011 2092 2100
    • (2011) Biochemistry , vol.50 , pp. 2092-2100
    • Cygan, N.K.1    Scheinost, J.C.2    Butters, T.D.3    Wentworth, P.J.4
  • 29


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.