A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 26, 2011, Pages 2802-2808

  Tomono, Susumu ^a   Miyoshi, Noriyuki ^a   Ito, Megumi ^a   Higashi, Tatsuya ^b   Ohshima, Hiroshi ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Derivatization; HMP; LC ESI MS MS; Secosterol

Indexed keywords

ALDOL REACTIONS; ALDOLIZATION PRODUCTS; ALZHEIMER'S DISEASE; BIOLOGICAL SPECIMENS; BRAIN TISSUE; C57BL/6 MICE; DERIVATIZATIONS; HIGHLY SENSITIVE; HMP; LC-ESI-MS; LC-ESI-MS/MS; LIMITS OF DETECTION; LUNG TISSUE; OZONOLYSIS; PATHOPHYSIOLOGICAL; SECOSTEROL;

CONDENSATION REACTIONS; HISTOLOGY; MAMMALS; NEURODEGENERATIVE DISEASES; OZONE; TISSUE;

CHOLESTEROL;

2 HYDRAZINO 1 METHYLPYRIDINE; 3BETA HYDROXY 5 OXO 5,6 SECOCHOLESTAN 6 AL; 3BETA HYDROXY 5BETA B NORCHOLESTANE 6BETA CARBOXALDEHYDE; CHOLESTEROL; CHOLESTEROL DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BRAIN; CHOLESTEROL BLOOD LEVEL; DERIVATIZATION; ELECTROSPRAY MASS SPECTROMETRY; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; LIVER; LUNG PARENCHYMA; MOUSE; NONHUMAN; OZONOLYSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REPRODUCIBILITY; SENSITIVITY ANALYSIS;

ANIMALS; CHOLESTEROL; CHROMATOGRAPHY, LIQUID; HYDRAZINES; LINEAR MODELS; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; OZONE; PYRIDINES; REPRODUCIBILITY OF RESULTS; SECOSTEROIDS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

MUS;

EID: 80052355323     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.08.004     Document Type: Article

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