Thymic involution as a predictor of early-onset neonatal sepsis

Paediatrics and International Child Health

Volumn 32, Issue 3, 2012, Pages 147-151

  Basu, Sriparna ^a   Dewangan, Shashikant ^a   Shukla, Ram Chandra ^b   Anupurva, Shampa ^b   Kumar, Ashok ^a  

^a BANARAS HINDU UNIVERSITY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

Blood culture; Early onset neonatal sepsis; Newborn; Thymic index; Thymic volume; Ultrasonography

Indexed keywords

INTERLEUKIN 6;

ARTICLE; CHORIOAMNIONITIS; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DISEASE MARKER; EARLY DIAGNOSIS; EARLY ONSET NEONATAL SEPSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GESTATIONAL AGE; HUMAN; INFECTION RISK; NEWBORN; NEWBORN ASSESSMENT; NEWBORN SEPSIS; ORGAN SIZE; PREDICTION; SENSITIVITY AND SPECIFICITY; THYMIC INVOLUTION; THYMUS DISEASE;

CLINICAL MEDICINE; COHORT STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFANT, NEWBORN; INTERLEUKIN-6; MALE; ORGAN SIZE; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SEPSIS; THYMUS GLAND; ULTRASONOGRAPHY;

EID: 84874905467     PISSN: 20469047     EISSN: 20469055     Source Type: Journal    
DOI: 10.1179/2046905512Y.0000000018     Document Type: Article

References (29)

1. Maayan-Metzger A, Barzilai A, Keller N, Kuint J. Are the 'good old' antibiotics still appropriate for early-onset neonatal sepsis? A 10 year survey. Isr Med Assoc J. 2009;11:138-42.
2. Nupponen I, Andersson S, Jarvenpaa AL, Kautiainen H, Repo H. Neutrophil CD11b expression and circulating interleukin-8 as diagnostic markers for early-onset neonatal sepsis. Pediatrics. 2001;108:E12.
3. Malik A, Hui CP, Pennie RA, Kirpalani H. Beyond the complete blood cell count and C-reactive protein: a systematic review of modern diagnostic tests for neonatal sepsis. Arch Pediatr Adolesc Med. 2003;157:511-16.
4. Alexander JM, McIntire DM, Leveno KJ. Chorioamnionitis and the prognosis for term infants. Obstet Gynecol. 1999;94:274-8.
5. De Felice C, Toti P, Santopietro R, Stumpo M, Pecciarini L, Bagnoli F. Small thymus in very low birth weight infants born to mothers with subclinical chorioamnionitis. J Pediatr. 1999;135:384-6.
6. Toti P, De Felice C, Stumpo M, Schürfeld K, Di Leo L, Vatti R, et al. Acute thymic involution in fetuses and neonates with chorioamnionitis. Hum Pathol. 2000;31:1121-8.
7. El-Haieg DO, Zidan AA, El-Nemr MM. The relationship between sonographic fetal thymus size and the components of the systemic fetal inflammatory response syndrome in women with preterm prelabour rupture of membranes. Br J Obstet Gynaecol. 2008;115:836-41.
8. Alexander JM, Gilstrap LC, Cox SM, McIntire DM, Leveno KJ. Clinical chorioamnionitis and the prognosis for very low birth weight infants. Obstet Gynecol. 1998;91:725-9.
9. Hasselbalch H, Jeepson LD, Ersboll AK, Engelmann DM, Nielsen MB. Thymus size evaluated by sonography. Acta Radiol. 1997;38:222-7.
10. Carol MR, Stephanie RW, Charboneau JW. In: Rumack, ed. Diagnostic Ultrasound, vol. 1, 2nd edn. Philadephia, PA: Mosby 1998; pp 410-30.
11. Toti P, De Felice C, Occhini R, Schuerfeld K, Stumpo M, Epistolato MC, et al. Spleen depletion in neonatal sepsis and chorioamnionitis. Am J Clin Pathol. 2004;122:765-71.
12. Savino W. The thymus gland is a target in malnutrition. Eur J Clin Nutr. 2002;56:S46-9.
13. Yarilin AA, Belyakov IM. Cytokines in the thymus: production and biological effects. Curr Med Chem. 2004;11:447-64.
14. Rodriguez-Galan MC, Bream JH, Farr A, Young HA. Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression. J Immunol. 2005;174:2796-804.
15. Li L, Hsu HC, Stockard CR, Yang P, Zhou J, Wu Q, et al. IL-12 inhibits thymic involution by enhancing IL-7-and IL-2-induced thymocyte proliferation. J Immunol. 2004;172:2909-16.
16. Aspinall R, Andrew D. Thymic involution in ageing. J Clin Immunol. 2000;20:250-6.
17. Raica M, Cimpean AM, Encica S, Cornea R. Involution of the thymus: a possible diagnostic pitfall. Rom J Morphol Embryol. 2007;48:101-6.
18. Gruver AL, Ventevogel MS, Sempowski GD. Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution. J Endocrinol. 2009;203:75-85.
19. Lewis VM, Twomey JJ, Bealmear P, Goldstein G, Good RA. Age, thymic involution, and circulating thymic hormone activity. J Clin Endocrinol Metab. 1978;47:145-50.
20. McDade TW, Beck MA, Kuzawa CW, Adair LS. Prenatal undernutrition and postnatal growth are associated with adolescent thymic function. J Nutr. 2001;131:1225-31.
21. Chandra RK. Serum thymic hormone activity and cellmediated immunity in healthy neonates, preterm infants, and small for gestational age infants. Pediatrics. 1981;67:407-11.
22. Gruver AL, Sempowski GD. Cytokines, leptin, and stressinduced thymic atrophy. J Leukoc Biol. 2008;84:915-23.
23. Tateyama H, Takahashi E, Saito Y, Fukai I, Fujii Y, Niwa H, et al. Histopathologic changes of thymoma preoperatively treated with corticosteroids. Virchows Arch. 2001;438:238-47.
24. Hick RW, Gruver AL, Ventevogel MS, Haynes BF, Sempowski GD. Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy. J Immunol. 2006;177:169-76.
25. Manley NR. Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation. Semin Immunol. 2000;12:421-8.
26. Palmer G, Aurrand-Lions M, Contassot E, Talabot-Ayer D, Ducrest-Gay D, Vesin C, et al. Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice. J Immunol. 2006;177:2899-907.
27. Trotter-Mayo RN, Roberts MR. Leptin acts in the periphery to protect thymocytes from glucocorticoid-mediated apoptosis in the absence of weight loss. Endocrinology. 2008;149:5209-18.
28. Kashlan F, Smulian J, Shen-Schwarz S, Anwar M, Hiatt M, Hegyi T. Umbilical vein interleukin 6 and tumor necrosis factor alpha plasma concentrations in the very preterm infant. Pediatr Infect Dis J. 2000;19:238-43.
29. Khassawneh M, Hayajneh WA, Kofahi H, Khader Y, Amarin Z, Daoud A. Diagnostic markers for neonatal sepsis: comparing C-reactive protein, interleukin-6 and immunoglobulin M. Scand J Immunol. 2007;65:171-5.