Concentration of exhaled breath condensate biomarkers after fractionated collection based on exhaled CO2 signal

Journal of Breath Research

Volumn 7, Issue 1, 2013, Pages

  Goldoni, Matteo ^a   Corradi, Massimo ^a   Mozzoni, Paola ^a   Folesani, Giuseppina ^a   Alinovi, Rossella ^a   Pinelli, Silvana ^a   Andreoli, Roberta ^a   Pigini, Daniela ^a   Tillo, Raffaella ^a   Filetti, Angela ^a   Garavelli, Claudia ^a   Mutti, Antonio ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 ISOPROSTANE; BIOLOGICAL MARKER; CARBON DIOXIDE; HYDROGEN PEROXIDE; MALONALDEHYDE; MITOCHONDRIAL DNA; 8 EPI PROSTAGLANDIN F2ALPHA; 8-EPI-PROSTAGLANDIN F2ALPHA; DRUG DERIVATIVE; PROSTAGLANDIN F2 ALPHA; QUATERNARY AMMONIUM DERIVATIVE;

ADULT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXHALATION; EXPIRED AIR; FEMALE; FRACTIONATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; BREATH ANALYSIS; METABOLISM; METHODOLOGY; PH; SMOKING;

ADULT; BIOLOGICAL MARKERS; BREATH TESTS; CARBON DIOXIDE; DINOPROST; EXHALATION; FEMALE; HUMANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; QUATERNARY AMMONIUM COMPOUNDS; SMOKING;

EID: 84874897848     PISSN: 17527155     EISSN: 17527163     Source Type: Journal    
DOI: 10.1088/1752-7155/7/1/017101     Document Type: Article

References (69)

1. Popov T A 2011 Human exhaled breath analysis Ann. Allergy Asthma Immunol. 106 451-6
2. Kharitonov S A and Barnes P J 2006 Exhaled biomarkers Chest 130 1541-6 (Pubitemid 44786751)
3. Dwyer T M 2004 Sampling airway surface liquid: non-volatiles in the exhaled breath condensate Lung 182 241-50 (Pubitemid 39315286)
4. Effros R M, Biller J, Foss B, Hoagland K, Dunning M B, Castillo D, Bosbous M, Sun F and Shaker R 2003 A simple method for estimating respiratory solute dilution in exhaled breath condensates Am. J. Respir. Crit. Care Med. 168 1500-5 (Pubitemid 38037336)
5. Almstrand A C, Bake B, Ljungstrom E, Larsson P, Bredberg A, Mirgorodskaya E and Olin A C 2010 Effect of airway opening on production of exhaled particles J. Appl. Physiol. 108 584-8
6. Haslbeck K, Schwartz K, Hohlfeld J M, Seume J R and Koch W 2010 Submicron droplet formation in the human lung J. Aerosol Sci. 41 429-38
7. Johnson G R and Morawska L 2009 The mechanism of breath aerosol formation J. Aerosol Med. Pulm. Drug Deliv. 22 229-37
8. Holmgren H, Ljungstrom E, Almstrand A C, Bake B and Olin A C 2010 Size distribution of exhaled particles in the range from 0.01 to 2.0 μm J. Aerosol Sci. 41 439-46
9. Heyder J 2004 Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery Proc. Am. Thorac. Soc. 1 315-20
10. Goldoni M et al 2009 Development and set-up of a portable device to monitor airway exhalation and deposition of particulate matter Biomarkers 14 326-39
11. Mutlu G M, Garey K W, Robbins R A, Danziger L H and Rubinstein I 2001 Collection and analysis of exhaled breath condensate in humans Am. J. Respir. Crit. Care Med. 164 731-7 PMID: 11549524 (Pubitemid 32881905)
12. Corradi M, Gergelova P and Mutti A 2010 Use of exhaled breath condensate to investigate occupational lung diseases Curr. Opin. Allergy Clin. Immunol. 10 93-8
13. Borrill Z L, Roy K and Singh D 2008 Exhaled breath condensate biomarkers in COPD Eur. Respir. J. 32 472-86
14. Kostikas K, Koutsokera A, Papiris S, Gourgoulianis K I and Loukides S 2008 Exhaled breath condensate in patients with asthma: implications for application in clinical practice Clin. Exp. Allergy 38 557-65 (Pubitemid 351406070)
15. Davis M D, Montpetit A and Hunt J 2012 Exhaled breath condensate: an overview Immunol. Allergy Clin. North Am. 32 363-75
16. Davis M D and Hunt J 2012 Exhaled breath condensate pH assays Immunol. Allergy Clin. North Am. 32 377-86
17. Chapman E A, Thomas P S and Yates D H 2010 Breath analysis in asbestos-related disorders: a review of the literature and potential future applications J. Breath Res. 4 034001
18. Inonu H, Doruk S, Sahin S, Erkorkmaz U, Celik D, Celikel S and Seyfikli Z 2012 Oxidative stress levels in exhaled breath condensate associated with COPD and smoking Respir. Care 57 413-9
19. Antczak A and Gorski P 2002 Markers of pulmonary diseases in exhaled breath condensate Int. J. Occup. Med. Environ. Health 15 317-23 PMID: 12608619 (Pubitemid 36055182)
20. Rosias P P, Dompeling E, Dentener M A, Pennings H J, Hendriks H J, Van Iersel M P and Jobsis Q 2004 Childhood asthma: exhaled markers of airway inflammation, asthma control score, and lung function tests Pediatr. Pulmonol. 38 107-14 (Pubitemid 38989729)
21. Poli D, Carbognani P, Corradi M, Goldoni M, Acampa O, Balbi B, Bianchi L, Rusca M and Mutti A 2005 Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study Respir. Res. 6 71 (Pubitemid 41410164)
22. Phillips M et al 2007 Prediction of lung cancer using volatile biomarkers in breath Cancer Biomark. 3 95-109 PMID: 17522431 (Pubitemid 47103811)
23. Corradi M, Goldoni M, Caglieri A, Folesani G, Poli D, Corti M and Mutti A 2008 Collecting exhaled breath condensate (EBC) with two condensers in series: a promising technique for studying the mechanisms of EBC formation, and the volatility of selected biomarkers J. Aerosol Med. Pulm. Drug Deliv. 21 35-44
24. Goldoni M, Caglieri A, Andreoli R, Poli D, Manini P, Vettori M V, Corradi M and Mutti A 2005 Influence of condensation temperature on selected exhaled breath parameters BMC Pulm. Med. 5 10 (Pubitemid 41461002)
25. Bondesson E, Jansson L T, Bengtsson T and Wollmer P 2009 Exhaled breath condensate - site and mechanisms of formation J. Breath Res. 3 016005
26. Vyas A, Zhang Q, Gunaratne S, Lee W, Lin J L, Lin J S, Warwick G and Thomas P S 2012 The effect of temperature on exhaled breath condensate collection J. Breath Res. 6 036002
27. Horvath I et al 2005 Exhaled breath condensate: methodological recommendations and unresolved questions Eur. Respir. J. 26 523-48 (Pubitemid 41264218)
28. Effros R M 2010 Exhaled breath condensate: delusion or dilution? Chest 138 471-2
29. Grob N M, Aytekin M and Dweik R A 2008 Biomarkers in exhaled breath condensate: a review of collection, processing and analysis J. Breath Res. 2 037004
30. Rosias P 2012 Methodological aspects of exhaled breath condensate collection and analysis J. Breath Res. 6 027102
31. Folesani G, Corradi M, Goldoni M, Manini P, Acampa O, Andreoli R, Bertorelli G, David S and Franchini I 2008 Urea in exhaled breath condensate of uraemics and patients with chronic airway diseases Acta Biomed. 79 79-86 PMID: 18924313
32. Davidsson A and Schmekel B 2010 Efficacy of two breath condensers J. Clin. Lab. Anal. 24 219-23
33. Hoffmeyer F, Raulf-Heimsoth M, Harth V, Bunger J and Bruning T 2009 Comparative analysis of selected exhaled breath biomarkers obtained with two different temperature-controlled devices BMC Pulm. Med. 9 48
34. Huttmann E M et al 2011 Comparison of two devices and two breathing patterns for exhaled breath condensate sampling PLoS ONE 6 e27467
35. Ohanian A S, Zimmerman J and Debley J S 2010 Effects of sample processing, time and storage condition on cysteinyl leukotrienes in exhaled breath condensate J. Breath Res. 4 046002
36. Rosias P P et al 2006 Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate Eur. Respir. J. 28 1036-41 (Pubitemid 46331976)
37. Soyer O U, Dizdar E A, Keskin O, Lilly C and Kalayci O 2006 Comparison of two methods for exhaled breath condensate collection Allergy 61 1016-8 (Pubitemid 44024902)
38. Bloemen K, Lissens G, Desager K and Schoeters G 2007 Determinants of variability of protein content, volume and pH of exhaled breath condensate Respir. Med. 101 1331-7 (Pubitemid 46667659)
39. Do R, Bartlett K H, Chu W, Dimich-Ward H and Kennedy S M 2008 Within- and between-person variability of exhaled breath condensate pH and NH(4)(+) in never and current smokers Respir. Med. 102 457-63 (Pubitemid 351179974)
40. Gajdocsi R, Bikov A, Antus B, Horvath I, Barnes P J and Kharitonov S A 2011 Assessment of reproducibility of exhaled hydrogen peroxide concentration and the effect of breathing pattern in healthy subjects J. Aerosol Med. Pulm. Drug Deliv. 24 271-5
41. Rosias P P, Robroeks C M, Kester A, den Hartog G J, Wodzig W K, Rijkers G T, Zimmermann L J, van Schayck C P, Jobsis Q and Dompeling E 2008 Biomarker reproducibility in exhaled breath condensate collected with different condensers Eur. Respir. J. 31 934-42
42. Fowler W S 1948 Lung function studies: II. The respiratory dead space Am. J. Physiol. 154 405-16 (available at ajplegacy.physiology.org/content/154/3/ 405.full.pdf+html)
43. Di Francesco F, Loccioni C, Fioravanti M, Russo A, Pioggia G, Ferro M, Roehrer I, Tabucchi S and Onor M 2008 Implementation of Fowler's method for end-tidal air sampling J. Breath Res. 2 037009
44. Moller W, Heimbeck I, Weber N, Saba G K, Korner B, Neiswirth M and Kohlhaufl M 2010 Fractionated exhaled breath condensate collection shows high hydrogen peroxide release in the airways J. Aerosol Med. Pulm. Drug Deliv. 23 129-35
45. Trischler J, Merkel N, Konitzer S, Muller C M, Unverzagt S and Lex C 2012 Fractionated breath condensate sampling: H(2)O(2) concentrations of the alveolar fraction may be related to asthma control in children Respir. Res. 13 14
46. Phillips M, Gleeson K, Hughes J M, Greenberg J, Cataneo R N, Baker L and McVay W P 1999 Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study Lancet 353 1930-3 (Pubitemid 29255706)
47. Jiang W W et al 2005 Increased mitochondrial DNA content in saliva associated with head and neck cancer Clin. Cancer Res. 11 2486-91 (Pubitemid 40569444)
48. Han W, Wang T, Reilly A A, Keller S M and Spivack S D 2009 Gene promoter methylation can be assayed in exhaled breath, and is increased in smokers and lung cancer patients Respir. Res. 10 86
49. Kordiak J, Szemraj J, Hamara K, Bialasiewicz P and Nowak D 2012 Complete surgical resection of lung tumor decreases exhalation of mutated KRAS oncogene Respir. Med. 106 1293-300
50. Andreoli R, Manini P, Corradi M, Mutti A and Niessen W M 2003 Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical ionization tandem mass spectrometry Rapid Commun. Mass Spectrom. 17 637-45 (Pubitemid 36373162)
51. Bartoli M L et al 2011 Malondialdehyde in exhaled breath condensate as a marker of oxidative stress in different pulmonary diseases Mediat. Inflamm. 2011 891752
52. Montuschi P, Barnes P J and Ciabattoni G 2010 Measurement of 8-isoprostane in exhaled breath condensate Methods Mol. Biol. 594 73-84
53. Corradi M, Pignatti P, Brunetti G, Goldoni M, Caglieri A, Nava S, Moscato G and Balbi B 2008 Comparison between exhaled and bronchoalveolar lavage levels of hydrogen peroxide in patients with diffuse interstitial lung diseases Acta Biomed. 79 73-78 PMID: 18924312
54. Tomasiak-Lozowska M M, Zietkowski Z, Przeslaw K, Tomasiak M, Skiepko R and Bodzenta-Lukaszyk A 2012 Inflammatory markers and acid-base equilibrium in exhaled breath condensate of stable and unstable asthma patients Int. Arch. Allergy Immunol. 159 121-9
55. + concentrations in asthma reflect reduced pulmonary production? Am. J. Respir. Crit. Care Med. 167 91 (author reply 91-92) PMID: 12502482
56. Hunt J 2006 Exhaled breath condensate pH: reflecting acidification of the airway at all levels Am. J. Respir. Crit. Care Med. 173 366-7 (Pubitemid 43228321)
57. Carraro S, Folesani G, Corradi M, Zanconato S, Gaston B and Baraldi E 2005 Acid-base equilibrium in exhaled breath condensate of allergic asthmatic children Allergy 60 476-81 (Pubitemid 40332973)
58. Corradi M, Folesani G, Gergelova P, Goldoni M, Pinelli S, Gainotti G, De Palma G and Mutti A 2012 Effect of salt-bromide-iodine thermal water inhalation on functional and biochemical lung parameters ISRN Pulmonol. 2012 534290 (available at www.hindawi.com/isrn/pulmonology/2012/534290/)
59. Corradi M, Gergelova P, Di Pilato E, Folesani G, Goldoni M, Andreoli R, Selis L and Mutti A 2012 Effect of exposure to detergents and other chemicals on biomarkers of pulmonary response in exhaled breath from hospital cleaners: a pilot study Int. Arch. Occup. Environ. Health 85 389-96
60. Barta I, Kullmann T, Csiszer E and Antus B 2010 Analysis of cytokine pattern in exhaled breath condensate of patients with squamous cell lung carcinoma Int. J. Biol. Markers 25 52-6 PMID: 20155714
61. Mazur W, Stark H, Sovijarvi A, Myllarniemi M and Kinnula V L 2009 Comparison of 8-isoprostane and interleukin-8 in induced sputum and exhaled breath condensate from asymptomatic and symptomatic smokers Respiration 78 209-16
62. Borrill Z L, Roy K, Vessey R S, Woodcock A A and Singh D 2008 Non-invasive biomarkers and pulmonary function in smokers Int. J. Chron. Obstruct. Pulmonol. Dis. 3 171-83 (Pubitemid 351523730)
63. Effros R M, Dunning M B 3rd, Biller J and Shaker R 2004 The promise and perils of exhaled breath condensates Am. J. Physiol. Lung Cell. Mol. Physiol. 287 L1073-80 (Pubitemid 39507182)
64. Gessner C, Hammerschmidt S, Kuhn H, Seyfarth H J, Sack U, Engelmann L, Schauer J and Wirtz H 2003 Exhaled breath condensate acidification in acute lung injury Respir. Med. 97 1188-94 (Pubitemid 37337014)
65. Greenwald R, Ferdinands J M and Teague W G 2009 Ionic determinants of exhaled breath condensate pH before and after exercise in adolescent athletes Pediatr. Pulmonol. 44 768-77
66. Wells K, Vaughan J, Pajewski T N, Hom S, Ngamtrakulpanit L, Smith A, Nguyen A, Turner R and Hunt J 2005 Exhaled breath condensate pH assays are not influenced by oral ammonia Thorax 60 27-31 (Pubitemid 40101014)
67. Effros R M, Casaburi R, Su J, Dunning M, Torday J, Biller J and Shaker R 2006 The effects of volatile salivary acids and bases on exhaled breath condensate pH Am. J. Respir. Crit. Care Med. 173 386-92 (Pubitemid 43228325)
68. Koutsokera A, Loukides S, Gourgoulianis K I and Kostikas K 2008 Biomarkers in the exhaled breath condensate of healthy adults: mapping the path towards reference values Curr. Med. Chem. 15 620-30 (Pubitemid 351516819)
69. Corradi M, Gergelova P, Goldoni M and Mutti A 2011 Exhaled nitric oxide in occupational respiratory medicine and environmental health: state of art Crit. Rev. Environ. Sci. Technol. 41 1820-42