메뉴 건너뛰기




Volumn 8, Issue , 2013, Pages 933-940

Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles

Author keywords

Metabolic profiling; Puerarin; Solid lipid nanoparticles

Indexed keywords

DRUG METABOLITE; PUERARIN; PUERARIN 4' O GLUCURONIDE; PUERARIN 7 O GLUCURONIDE; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG;

EID: 84874857868     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S39349     Document Type: Article
Times cited : (36)

References (25)
  • 1
    • 0023804694 scopus 로고
    • Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats
    • Chinese
    • Song XP, Chen PP, Chai XS. Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats. Zhongguo Yao Li Xue Bao. 1988;9(1):55-58. Chinese.
    • (1988) Zhongguo Yao Li Xue Bao. , vol.9 , Issue.1 , pp. 55-58
    • Song, X.P.1    Chen, P.P.2    Chai, X.S.3
  • 2
    • 67149102151 scopus 로고    scopus 로고
    • Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia
    • Gao L, Ji X, Song J, et al. Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia. Neurol Res. 2009;31(4): 402-406.
    • (2009) Neurol Res. , vol.31 , Issue.4 , pp. 402-406
    • Gao, L.1    Ji, X.2    Song, J.3
  • 3
    • 33646449792 scopus 로고    scopus 로고
    • Puerarin induces angiogenesis in myocardium of rat with myocardial infarction
    • Zhang S, Chen S, Shen Y, et al. Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. Biol Pharm Bull. 2006;29(5):945-950.
    • (2006) Biol Pharm Bull. , vol.29 , Issue.5 , pp. 945-950
    • Zhang, S.1    Chen, S.2    Shen, Y.3
  • 4
    • 0038204299 scopus 로고    scopus 로고
    • Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats
    • Hsu FL, Liu IM, Kuo DH, Chen WC, Su HC, Cheng JT. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod. 2003;66(6):788-792.
    • (2003) J Nat Prod. , vol.66 , Issue.6 , pp. 788-792
    • Hsu, F.L.1    Liu, I.M.2    Kuo, D.H.3    Chen, W.C.4    Su, H.C.5    Cheng, J.T.6
  • 5
    • 26444471844 scopus 로고    scopus 로고
    • The study of anti-metabolic syndrome effect of puerarin in vitro
    • Xu ME, Xiao SZ, Sun YH, Zheng XX, Ou-Yang Y, Guan C. The study of anti-metabolic syndrome effect of puerarin in vitro. Life Sci. 2005;77(25):3183-3196.
    • (2005) Life Sci. , vol.77 , Issue.25 , pp. 3183-3196
    • Xu, M.E.1    Xiao, S.Z.2    Sun, Y.H.3    Zheng, X.X.4    Ou-Yang, Y.5    Guan, C.6
  • 6
    • 33745797747 scopus 로고    scopus 로고
    • Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats
    • Yan LP, Chan SW, Chan AS, Chen SL, Ma XJ, Xu HX. Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Life Sci. 2006;79(4):324-330.
    • (2006) Life Sci. , vol.79 , Issue.4 , pp. 324-330
    • Yan, L.P.1    Chan, S.W.2    Chan, A.S.3    Chen, S.L.4    Ma, X.J.5    Xu, H.X.6
  • 7
    • 34147107123 scopus 로고    scopus 로고
    • Puerarin and conjugate bases as radical scavengers and antioxidants: Molecular mechanism and synergism with beta-carotene
    • Han RM, Tian YX, Becker EM, Andersen ML, Zhang JP, Skibsted LH. Puerarin and conjugate bases as radical scavengers and antioxidants: Molecular mechanism and synergism with beta-carotene. J Agric Food Chem. 2007;55(6):2384-2391.
    • (2007) J Agric Food Chem. , vol.55 , Issue.6 , pp. 2384-2391
    • Han, R.M.1    Tian, Y.X.2    Becker, E.M.3    Andersen, M.L.4    Zhang, J.P.5    Skibsted, L.H.6
  • 8
    • 72049109482 scopus 로고    scopus 로고
    • Puerarin inhibits adhesion molecule expression in TNF-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway
    • Hu W, Zhang Q, Yang X, Wang Y, Sun L. Puerarin inhibits adhesion molecule expression in TNF-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway. Pharmacology. 2010;85(1):27-35.
    • (2010) Pharmacology. , vol.85 , Issue.1 , pp. 27-35
    • Hu, W.1    Zhang, Q.2    Yang, X.3    Wang, Y.4    Sun, L.5
  • 9
    • 77954754224 scopus 로고    scopus 로고
    • Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris
    • Yang X, Hu W, Zhang Q, Wang Y, Sun L. Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris. Basic Clin Pharmacol Toxicol. 2010;107(2):637-642.
    • (2010) Basic Clin Pharmacol Toxicol. , vol.107 , Issue.2 , pp. 637-642
    • Yang, X.1    Hu, W.2    Zhang, Q.3    Wang, Y.4    Sun, L.5
  • 10
    • 81255176611 scopus 로고    scopus 로고
    • Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase
    • Hwang YP, Kim HG, Hien TT, Jeong MH, Jeong TC, Jeong HG. Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase. Toxicol Appl Pharmacol. 2011;257(1):48-58.
    • (2011) Toxicol Appl Pharmacol. , vol.257 , Issue.1 , pp. 48-58
    • Hwang, Y.P.1    Kim, H.G.2    Hien, T.T.3    Jeong, M.H.4    Jeong, T.C.5    Jeong, H.G.6
  • 12
    • 2942590320 scopus 로고    scopus 로고
    • Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry
    • Prasain JK, Jones K, Brissie N, Moore R, Wyss JM, Barnes S. Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry. J Agric Food Chem. 2004; 52(12):3708-3712.
    • (2004) J Agric Food Chem. , vol.52 , Issue.12 , pp. 3708-3712
    • Prasain, J.K.1    Jones, K.2    Brissie, N.3    Moore, R.4    Wyss, J.M.5    Barnes, S.6
  • 13
    • 58149352381 scopus 로고    scopus 로고
    • Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometry
    • Prasain JK, Peng N, Moore R, Arabshahi A, Barnes S, Wyss JM. Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometry. Phytomedicine. 2009;16(1):65-71.
    • (2009) Phytomedicine. , vol.16 , Issue.1 , pp. 65-71
    • Prasain, J.K.1    Peng, N.2    Moore, R.3    Arabshahi, A.4    Barnes, S.5    Wyss, J.M.6
  • 14
    • 0028919111 scopus 로고
    • Urinary and biliary metabolites of puerarin in rats
    • Yasuda T, Kano Y, Saito K, Ohsawa K. Urinary and biliary metabolites of puerarin in rats. Biol Pharm Bull. 1995;18(2):300-303.
    • (1995) Biol Pharm Bull. , vol.18 , Issue.2 , pp. 300-303
    • Yasuda, T.1    Kano, Y.2    Saito, K.3    Ohsawa, K.4
  • 15
    • 84871200721 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes
    • Luo CF, Cai B, Hou N, et al. UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes. Arch Toxicol. 2012;86(11):1681-1690.
    • (2012) Arch Toxicol. , vol.86 , Issue.11 , pp. 1681-1690
    • Luo, C.F.1    Cai, B.2    Hou, N.3
  • 16
    • 74349128354 scopus 로고    scopus 로고
    • Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: Similar metabolic profiles in liver and intestine of rats
    • Luo CF, Yuan M, Chen MS, Liu SM, Ji H. Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: similar metabolic profiles in liver and intestine of rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878(3-4):363-370.
    • (2010) J Chromatogr B Analyt Technol Biomed Life Sci. , vol.878 , Issue.3-4 , pp. 363-370
    • Luo, C.F.1    Yuan, M.2    Chen, M.S.3    Liu, S.M.4    Ji, H.5
  • 17
    • 34248169123 scopus 로고    scopus 로고
    • Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin
    • Quan DQ, Xu GX, Wu XG. Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin. Chem Pharm Bull (Tokyo). 2007;55(5):800-803.
    • (2007) Chem Pharm Bull (Tokyo). , vol.55 , Issue.5 , pp. 800-803
    • Quan, D.Q.1    Xu, G.X.2    Wu, X.G.3
  • 18
    • 79955619107 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration
    • Luo CF, Yuan M, Chen MS, et al. Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration. Int J Pharm. 2011;410(1-2):138-144.
    • (2011) Int J Pharm. , vol.410 , Issue.1-2 , pp. 138-144
    • Luo, C.F.1    Yuan, M.2    Chen, M.S.3
  • 19
    • 57349171371 scopus 로고    scopus 로고
    • Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery
    • Muchow M, Maincent P, Muller RH. Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery. Drug Dev Ind Pharm. 2008;34(12):1394-1405.
    • (2008) Drug Dev Ind Pharm. , vol.34 , Issue.12 , pp. 1394-1405
    • Muchow, M.1    Maincent, P.2    Muller, R.H.3
  • 20
    • 67349203156 scopus 로고    scopus 로고
    • Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery
    • Paliwal R, Rai S, Vaidya B, et al. Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery. Nanomedicine. 2009;5(2):184-191.
    • (2009) Nanomedicine. , vol.5 , Issue.2 , pp. 184-191
    • Paliwal, R.1    Rai, S.2    Vaidya, B.3
  • 21
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
    • Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol. 2000;40:581-616.
    • (2000) Annu Rev Pharmacol Toxicol. , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 22
    • 28144464297 scopus 로고    scopus 로고
    • Disposition of flavonoids via recycling: Comparison of intestinal versus hepatic disposition
    • Chen J, Wang S, Jia X, et al. Disposition of flavonoids via recycling: comparison of intestinal versus hepatic disposition. Drug Metab Dispos. 2005;33(12):1777-1784.
    • (2005) Drug Metab Dispos. , vol.33 , Issue.12 , pp. 1777-1784
    • Chen, J.1    Wang, S.2    Jia, X.3
  • 23
    • 0027383287 scopus 로고
    • Plasma concentrations of phyto-oestrogens in Japanese men
    • Adlercreutz H, Markkanen H, Watanabe S. Plasma concentrations of phyto-oestrogens in Japanese men. Lancet. 1993;342(8881): 1209-1210.
    • (1993) Lancet. , vol.342 , Issue.8881 , pp. 1209-1210
    • Adlercreutz, H.1    Markkanen, H.2    Watanabe, S.3
  • 24
    • 65449157258 scopus 로고    scopus 로고
    • Quercetin glucuronide inhibits cell migration and proliferation by platelet-derived growth factor in vascular smooth muscle cells
    • Ishizawa K, Izawa-Ishizawa Y, Ohnishi S, et al. Quercetin glucuronide inhibits cell migration and proliferation by platelet-derived growth factor in vascular smooth muscle cells. J Pharmacol Sci. 2009;109(2):257-264.
    • (2009) J Pharmacol Sci. , vol.109 , Issue.2 , pp. 257-264
    • Ishizawa, K.1    Izawa-Ishizawa, Y.2    Ohnishi, S.3
  • 25
    • 84858052503 scopus 로고    scopus 로고
    • Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation
    • Galindo P, Rodriguez-Gómez I, González-Manzano S, et al. Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. PLoS One. 2012;7(3):e32673.
    • (2012) PLoS One. , vol.7 , Issue.3
    • Galindo, P.1    Rodriguez-Gómez, I.2    González-Manzano, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.