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Volumn 8, Issue 1, 2013, Pages 9-22

Clinical trials in irritable Bowel syndrome: A review

Author keywords

Abdominal pain; Bowel functions; Constipation predominant; Diarrhea predominant; Irritable bowel syndrome

Indexed keywords

ALOSETRON; AMITRIPTYLINE; ASIMADOLINE; AZD7371; CROFELEMER; DNK333; LINACLOTIDE; LUBIPROSTONE; LX1031; OXYGENASE INHIBITOR; PHLOROGLUCINOL; PLACEBO; RECEPTOR BLOCKING AGENT; RENZAPRIDE; RIFAXIMIN; SEROTONIN 1A ANTAGONIST; TEGASEROD; UNCLASSIFIED DRUG;

EID: 84874856941     PISSN: 15748871     EISSN: 18761038     Source Type: Journal    
DOI: 10.2174/1574887111308010003     Document Type: Article
Times cited : (13)

References (52)
  • 1
    • 0025843521 scopus 로고
    • Irritable bowel syndrome in office-based practice in the United States
    • Everhart JE, Renault PF. Irritable bowel syndrome in office-based practice in the United States. Gastroenterology 1991; 100: 998-1005.
    • (1991) Gastroenterology , vol.100 , pp. 998-1005
    • Everhart, J.E.1    Renault, P.F.2
  • 2
    • 0032692830 scopus 로고    scopus 로고
    • A national survey of practice patterns of gastroenterologists with comparison to the past two decades
    • Russo MW, Gaynes BN, Drossman DA. A national survey of practice patterns of gastroenterologists with comparison to the past two decades. J Clin Gastroenterol 1999; 29: 339-43.
    • (1999) J Clin Gastroenterol , vol.29 , pp. 339-343
    • Russo, M.W.1    Gaynes, B.N.2    Drossman, D.A.3
  • 4
    • 0027185528 scopus 로고
    • US householder survey of functional gastrointestinal disorders: Prevalence, sociodemography, and health impact
    • Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, et al. US householder survey of functional gastrointestinal disorders: prevalence, sociodemography, and health impact. Dig Dis Sci 1993; 38: 1569-80.
    • (1993) Dig Dis Sci , vol.38 , pp. 1569-1580
    • Drossman, D.A.1    Li, Z.2    Andruzzi, E.3    Temple, R.D.4    Talley, N.J.5    Thompson, W.G.6
  • 7
    • 0032943840 scopus 로고    scopus 로고
    • Impact of irritable bowel syndrome on quality of life and resource use in the United States and United Kingdom
    • Hahn BA, Yan S, Strassels S. Impact of irritable bowel syndrome on quality of life and resource use in the United States and United Kingdom. Digestion 1999; 60: 77-81.
    • (1999) Digestion , vol.60 , pp. 77-81
    • Hahn, B.A.1    Yan, S.2    Strassels, S.3
  • 8
    • 0031940237 scopus 로고    scopus 로고
    • Quality of life in persons with irritable bowel syndrome: Development and validation of a new measure
    • Patrick DL, Drossman DA, Frederick IO, Dicesare J, Puder KL. Quality of life in persons with irritable bowel syndrome: development and validation of a new measure. Dig Dis Sci 1998; 43: 400-11.
    • (1998) Dig Dis Sci , vol.43 , pp. 400-411
    • Patrick, D.L.1    Drossman, D.A.2    Frederick, I.O.3    Dicesare, J.4    Puder, K.L.5
  • 10
  • 11
    • 0033986139 scopus 로고    scopus 로고
    • The impact of functional gastrointestinal disorders on quality of life
    • Koloski N, Talley NJ, Boyce PM. The impact of functional gastrointestinal disorders on quality of life. Am J Gastoenterol 2000; 95: 67-71.
    • (2000) Am J Gastoenterol , vol.95 , pp. 67-71
    • Koloski, N.1    Talley, N.J.2    Boyce, P.M.3
  • 12
    • 0036677477 scopus 로고    scopus 로고
    • Health-related quality of life in functional GI disorders: Focus on constipation and resource utilization
    • Irvine EJ, Ferrazzi S, Pare P, Thompson WG, Rance L. Health-related quality of life in functional GI disorders: focus on constipation and resource utilization. Am J Gastroenterol 2002; 97: 1986-93.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1986-1993
    • Irvine, E.J.1    Ferrazzi, S.2    Pare, P.3    Thompson, W.G.4    Rance, L.5
  • 13
    • 0035123901 scopus 로고    scopus 로고
    • Alosetron improves quality of life in women with diarrheapredominant irritable bowel syndrome
    • Watson ME, Lacey L, Kong S, Northcutt AR, McSorley D, Hahn B, et al. Alosetron improves quality of life in women with diarrheapredominant irritable bowel syndrome. Am J Gastroenterol 2001; 96: 455-9.
    • (2001) Am J Gastroenterol , vol.96 , pp. 455-459
    • Watson, M.E.1    Lacey, L.2    Kong, S.3    Northcutt, A.R.4    McSorley, D.5    Hahn, B.6
  • 14
    • 0142027693 scopus 로고    scopus 로고
    • Systematic review: The economic impact of irritable bowel syndrome
    • Inadomi JM, Fennerty MB, Bjorkman D. Systematic review: the economic impact of irritable bowel syndrome. Aliment Pharmacol Ther 2003; 18: 671-82.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 671-682
    • Inadomi, J.M.1    Fennerty, M.B.2    Bjorkman, D.3
  • 17
    • 23844543847 scopus 로고    scopus 로고
    • The impact of IBS on absenteeism and work productivity: United States and eight European countries
    • Hungin P, Barghout V, Kahler K. The impact of IBS on absenteeism and work productivity: United States and eight European countries. Am J Gastroenterol 2003; 98(Suppl): S227.
    • (2003) Am J Gastroenterol , vol.98 , Issue.SUPPL.
    • Hungin, P.1    Barghout, V.2    Kahler, K.3
  • 19
    • 0037357895 scopus 로고    scopus 로고
    • The prevalence, patterns and impact of irritable bowel syndrome: An international survey of 40,000 subjects
    • Hungin APS, Whorwell PJ, Tack J, Mearin F. The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects. Aliment Pharmacol Ther 2003; 17: 643-50.
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 643-650
    • Hungin, A.P.S.1    Whorwell, P.J.2    Tack, J.3    Mearin, F.4
  • 22
    • 0032922539 scopus 로고    scopus 로고
    • Review article: Safety and efficacy of alosetron, a 5HT3 receptor antagonist, in female irritable bowel syndrome patients
    • Mangel AW, Northcutt AR. Review article: safety and efficacy of alosetron, a 5HT3 receptor antagonist, in female irritable bowel syndrome patients. Aliment Pharmacol Ther 1999; 13(Suppl 2): 77-82.
    • (1999) Aliment Pharmacol Ther , vol.13 , Issue.SUPPL. 2 , pp. 77-82
    • Mangel, A.W.1    Northcutt, A.R.2
  • 23
    • 2542465496 scopus 로고    scopus 로고
    • US Department of Health and Human Services, Center for Drug Evaluation and Research (CDER). Guidance for Industry-Irritable bowel Syndrome-Clinical Evaluation of Drugs for Treatment. Food and Drug Administration. [cited: 27 July 2012]. Silver Spring (MD): Food and Drug Administration. May Available from
    • US Department of Health and Human Services. Food and Drug Administration. Center for Drug Evaluation and Research (CDER). Guidance for Industry-Irritable bowel Syndrome-Clinical Evaluation of Drugs for Treatment. Food and Drug Administration. [cited: 27 July 2012]. Silver Spring (MD): Food and Drug Administration. May 2012. Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidance s/UCM205269.pdf.
    • (2012) Food and Drug Administration
  • 24
    • 72949116164 scopus 로고    scopus 로고
    • The FDA and IBS drug development
    • Mangel AW. The FDA and IBS drug development. Am J Gastroenterol 2009; 104: 3106.
    • (2009) Am J Gastroenterol , vol.104 , pp. 3106
    • Mangel, A.W.1
  • 26
    • 0033963225 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome
    • Bardhan KD, Bodeman G, Geldof H, Schütz E, Heath A, Mills JG, et al. A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 2000; 14: 23-34.
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 23-34
    • Bardhan, K.D.1    Bodeman, G.2    Geldof, H.3    Schütz, E.4    Heath, A.5    Mills, J.G.6
  • 27
    • 0034827794 scopus 로고    scopus 로고
    • Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome
    • Lembo T, Wright RA, Bagby B, Decker C, Gordon S, Jhingran P, et al. Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 2001; 96: 2662-70.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2662-2670
    • Lembo, T.1    Wright, R.A.2    Bagby, B.3    Decker, C.4    Gordon, S.5    Jhingran, P.6
  • 28
    • 3542992125 scopus 로고    scopus 로고
    • Effect of alosetron on bowel urgency and global symptoms in women with severe diarrhea-predominant irritable bowel syndrome: Analysis of two controlled trials
    • Lembo AJ, Olden KW, Ameen VZ, Gordon SL, Heath AT, Carter EG. Effect of alosetron on bowel urgency and global symptoms in women with severe diarrhea-predominant irritable bowel syndrome: analysis of two controlled trials. Clin Gastroenterol Hepatol 2004; 2: 675-82.
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 675-682
    • Lembo, A.J.1    Olden, K.W.2    Ameen, V.Z.3    Gordon, S.L.4    Heath, A.T.5    Carter, E.G.6
  • 29
    • 8744229903 scopus 로고    scopus 로고
    • Long-term safety and efficacy of alosetron in women with severe diarrhea-predominant irritable bowel syndrome
    • Chey WD, Chey WY, Heath AT, et al. Long-term safety and efficacy of alosetron in women with severe diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 2004; 99: 2195-203.
    • (2004) Am J Gastroenterol , vol.99 , pp. 2195-2203
    • Chey, W.D.1    Chey, W.Y.2    Heath, A.T.3
  • 30
    • 0034917335 scopus 로고    scopus 로고
    • A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome
    • Camilleri M, Chey WY, Mayer EA, et al. A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med 2001; 161: 1733-40.
    • (2001) Arch Intern Med , vol.161 , pp. 1733-1740
    • Camilleri, M.1    Chey, W.Y.2    Mayer, E.A.3
  • 31
    • 13744263696 scopus 로고    scopus 로고
    • A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS
    • Chang L, Ameen VZ, Dukes GE, McSorley DJ, Carter EG, Mayer EA. A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS. Am J Gastroenterol 2005; 100: 115-23.
    • (2005) Am J Gastroenterol , vol.100 , pp. 115-123
    • Chang, L.1    Ameen, V.Z.2    Dukes, G.E.3    McSorley, D.J.4    Carter, E.G.5    Mayer, E.A.6
  • 32
    • 0036897288 scopus 로고    scopus 로고
    • Patient satisfaction with alosetron for the treatment of women with diarrhea-predominant ir ritable bowel syndrome
    • Olden K, DeGarmo RG, Jhingran P, et al. Patient satisfaction with alosetron for the treatment of women with diarrhea-predominant ir ritable bowel syndrome. Am J Gastroenterol 2002; 97: 3139-46.
    • (2002) Am J Gastroenterol , vol.97 , pp. 3139-3146
    • Olden, K.1    DeGarmo, R.G.2    Jhingran, P.3
  • 33
    • 34547626592 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study to assess efficacy and safety of 0.5 mg and 1 mg alosetron in women with severe diarrhea-predominant IBS
    • Krause R, Ameen V, Gordon SH, West M, Heath AT, Perschy Tet al. A randomized, double-blind, placebo-controlled study to assess efficacy and safety of 0.5 mg and 1 mg alosetron in women with severe diarrhea-predominant IBS. Am J Gastroenterol 2007; 102: 1709-19.
    • (2007) Am J Gastroenterol , vol.102 , pp. 1709-1719
    • Krause, R.1    Ameen, V.2    Gordon, S.H.3    West, M.4    Heath, A.T.5    Perschy, T.6
  • 35
    • 35548931920 scopus 로고    scopus 로고
    • Efficacy of on-demand asimadoline, a peripheral K-opioid agonist, in females with irritable bowel syndrome
    • Szarka LA, Camilleri M, Burton D, Fox JC, McKinzie S, Stanislav T, et al. Efficacy of on-demand asimadoline, a peripheral K-opioid agonist, in females with irritable bowel syndrome. Clin Gastroenterol Hepatol 2007; 5: 1268-75.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 1268-1275
    • Szarka, L.A.1    Camilleri, M.2    Burton, D.3    Fox, J.C.4    McKinzie, S.5    Stanislav, T.6
  • 36
    • 33750721328 scopus 로고    scopus 로고
    • The effect of a nonabsorbed oral antiotic (rifaximin) on the symptoms of the irritable bowel syndrome: A randomized trial
    • Pimentel M, Park S, Mirocha J, Kane SV, Kong Y. The effect of a nonabsorbed oral antiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann Intern Med 2006; 145: 557-63.
    • (2006) Ann Intern Med , vol.145 , pp. 557-563
    • Pimentel, M.1    Park, S.2    Mirocha, J.3    Kane, S.V.4    Kong, Y.5
  • 37
    • 78650864077 scopus 로고    scopus 로고
    • Rifaximin therapy for patients with irritable bowel syndrome without constipation
    • Pimentel M, Lembo A, Chey WD, Zakko S, Ringel Y, Yu J, et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Eng J Med 2011; 364: 22-32.
    • (2011) N Eng J Med , vol.364 , pp. 22-32
    • Pimentel, M.1    Lembo, A.2    Chey, W.D.3    Zakko, S.4    Ringel, Y.5    Yu, J.6
  • 38
    • 80051486125 scopus 로고    scopus 로고
    • The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel irritable bowel syndrome
    • Brown PM, Drossman DA, Wood AJ, et al. The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel irritable bowel syndrome. Gastroenterology 2011; 141: 507-16.
    • (2011) Gastroenterology , vol.141 , pp. 507-516
    • Brown, P.M.1    Drossman, D.A.2    Wood, A.J.3
  • 39
    • 40949125251 scopus 로고    scopus 로고
    • Clinical trial: The effect of amitriptyline in patients with diarrhea-predominant irritable bowel syndrome
    • Vahedi H, Merat S, Momtahen S, Kazzazi AS, Ghaffari N, Olfati G, et al. Clinical trial: the effect of amitriptyline in patients with diarrhea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2008; 27: 678-84.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 678-684
    • Vahedi, H.1    Merat, S.2    Momtahen, S.3    Kazzazi, A.S.4    Ghaffari, N.5    Olfati, G.6
  • 40
    • 57649120166 scopus 로고    scopus 로고
    • Evaluation of crofelemer in the treatment of diarrhea-predomiant irritable bowel syndrome patients
    • Mangel AW, Chaturvedi P. Evaluation of crofelemer in the treatment of diarrhea-predomiant irritable bowel syndrome patients. Digestion 2008; 78: 180-186.
    • (2008) Digestion , vol.78 , pp. 180-186
    • Mangel, A.W.1    Chaturvedi, P.2
  • 41
    • 79956138710 scopus 로고    scopus 로고
    • Randomised clinical trial: The clinical effects of a novel neurokinin receptor antagonist, DNK333, in women with diarrhea-predominant irritable bowel syndrome
    • Zakko S, Barton G, Weber E, Dunger-Baldauf C, Ruhl A. Randomised clinical trial: the clinical effects of a novel neurokinin receptor antagonist, DNK333, in women with diarrhea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2011; 33: 1311-21.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 1311-1321
    • Zakko, S.1    Barton, G.2    Weber, E.3    Dunger-Baldauf, C.4    Ruhl, A.5
  • 42
    • 78649690668 scopus 로고    scopus 로고
    • Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    • Johnston JM, Kurtz CB, Macdougall JE, Lavins BJ, Currie MG, Fitch DA, et al. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation. Gastorenterology 2010; 139: 1877-86.
    • (2010) Gastorenterology , vol.139 , pp. 1877-1886
    • Johnston, J.M.1    Kurtz, C.B.2    Macdougall, J.E.3    Lavins, B.J.4    Currie, M.G.5    Fitch, D.A.6
  • 43
    • 40949131857 scopus 로고    scopus 로고
    • Clinical trial: Phase 2 study of lubiprosotone for irritable bowel syndrome with constipation
    • Johanson JF, Drossman DA, Panas R, Wahle A, Ueno R. Clinical trial: phase 2 study of lubiprosotone for irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2008; 27: 685-96.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 685-696
    • Johanson, J.F.1    Drossman, D.A.2    Panas, R.3    Wahle, A.4    Ueno, R.5
  • 44
    • 58149103805 scopus 로고    scopus 로고
    • Clinical trial: Lubiprostone in patients with constipationassociated irritable bowel syndrome-results of two randomized, placebo-controlled studies
    • Drossman DA, Chey WD, Johanson JF, Fass R, Scott C, Panas R, et al. Clinical trial: lubiprostone in patients with constipationassociated irritable bowel syndrome-results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther 2009; 29: 329-41.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 329-341
    • Drossman, D.A.1    Chey, W.D.2    Johanson, J.F.3    Fass, R.4    Scott, C.5    Panas, R.6
  • 45
    • 0036829638 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation
    • Novick J, Miner P, Krause R, et al. A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2002; 16: 1877-88.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1877-1888
    • Novick, J.1    Miner, P.2    Krause, R.3
  • 46
    • 0037799916 scopus 로고    scopus 로고
    • An Asia-Pacific, double blind, placebo controlled, randomized study to evaluate the efficacy, safety, and tolerability of tegaserod in patients with irritable bowel syndrome
    • Kellow J, Lee Oy, Chang FY. An Asia-Pacific, double blind, placebo controlled, randomized study to evaluate the efficacy, safety, and tolerability of tegaserod in patients with irritable bowel syndrome. Gut 2003; 62: 671-6.
    • (2003) Gut , vol.62 , pp. 671-676
    • Kellow, J.1    Lee Oy Chang, F.Y.2
  • 47
    • 1342309961 scopus 로고    scopus 로고
    • A double-blind, placebocontrolled, randomized study to evaluate the efficacy, safety and tolerability of tegaserod in patients with irritable bowel syndrome
    • Nyhlin H, Bang C, Elsborg L, et al. A double-blind, placebocontrolled, randomized study to evaluate the efficacy, safety and tolerability of tegaserod in patients with irritable bowel syndrome. Scand J Gastroenterol 2004; 39: 119-26.
    • (2004) Scand J Gastroenterol , vol.39 , pp. 119-126
    • Nyhlin, H.1    Bang, C.2    Elsborg, L.3
  • 48
    • 43549127335 scopus 로고    scopus 로고
    • Tegaserod for female patients suffering from IBS with mixed bowel habits or constipation: A randomized controlled trial
    • Chey WD, Pare P, Viegas A, Ligozio G, Shetzline MA. Tegaserod for female patients suffering from IBS with mixed bowel habits or constipation: a randomized controlled trial. Am J Gastroentero. l 2008; 103: 1217-25.
    • (2008) Am J Gastroentero. l , vol.103 , pp. 1217-1225
    • Chey, W.D.1    Pare, P.2    Viegas, A.3    Ligozio, G.4    Shetzline, M.A.5
  • 49
    • 41849096775 scopus 로고    scopus 로고
    • Clinical trial: Renapride therapy for constipation-predominant irritable bowel syndromemulticentre, randomized, placebo-controlled, double-blind study in primary healthcare setting
    • George AM, Meyers NL, RI Hickling. Clinical trial: renapride therapy for constipation-predominant irritable bowel syndromemulticentre, randomized, placebo-controlled, double-blind study in primary healthcare setting. Aliment Pharmacol Ther 2008; 27: 830-37.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 830-837
    • George, A.M.1    Meyers, N.L.2    Hickling, R.I.3
  • 50
    • 55949095879 scopus 로고    scopus 로고
    • Identification of patients with non-D, non-C irritable bowel syndrome and treatment with renzapride: An exploratory, multicenter, randomized, double-blind, placebo-controlled clinical trial
    • Spiller RC, Meyers NL, Hickling RI. Identification of patients with non-D, non-C irritable bowel syndrome and treatment with renzapride: an exploratory, multicenter, randomized, double-blind, placebo-controlled clinical trial. Dig Dis Sci 2008; 53: 3191-200.
    • (2008) Dig Dis Sci , vol.53 , pp. 3191-3200
    • Spiller, R.C.1    Meyers, N.L.2    Hickling, R.I.3
  • 51
    • 53149147052 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of the 5HT1A receptor antagonist AZD7371 tartrate monohydrate (robalzotan tartrate monohydrate) in patients with irritable bowel syndrome
    • Drossman DA, Danilewitz M, Naesdal J, Hwang C, Adler J, Silberg DG. Randomized, double-blind, placebo-controlled trial of the 5HT1A receptor antagonist AZD7371 tartrate monohydrate (robalzotan tartrate monohydrate) in patients with irritable bowel syndrome. Am J Gastroenterol 2008; 103: 2562-69.
    • (2008) Am J Gastroenterol , vol.103 , pp. 2562-2569
    • Drossman, D.A.1    Danilewitz, M.2    Naesdal, J.3    Hwang, C.4    Adler, J.5    Silberg, D.G.6
  • 52
    • 34247100202 scopus 로고    scopus 로고
    • Acute exacerbation of pain in irritable bowel syndrome: Efficacy of phloroglucinol/trimethylphloroglucinol-a randomized, doubleblind, placebo-controlled study
    • Chassany O, Bonaz B, Bruley des Varannes S, Bueno L, et al. Acute exacerbation of pain in irritable bowel syndrome: efficacy of phloroglucinol/trimethylphloroglucinol-a randomized, doubleblind, placebo-controlled study. Aliment Pharmacol Ther 2007; 25: 1115-23.
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 1115-1123
    • Chassany, O.1    Bonaz, B.2    Bruley des Varannes, S.3    Bueno, L.4


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