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Volumn , Issue , 2009, Pages 1-15

Pathway for the development of drugs to treat irritable bowel syndrome: From molecule identification through approval

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EID: 84895252309     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (1)

References (48)
  • 1
    • 84895310581 scopus 로고    scopus 로고
    • The AMCP Format for Formulary Submissions
    • Academy of Managed Care Pharmacy, Version 2.1. April 2005, Available from
    • Academy of Managed Care Pharmacy. The AMCP Format for Formulary Submissions.Version 2.1. April 2005. 2008 Available from:http://www.fmcpnet org/data/resource/-Format~Version_2_1~Final_Final.pdf.
    • (2008)
  • 2
    • 84895310581 scopus 로고    scopus 로고
    • AMCP Format for Formulary Submissions Version 2.1 Explanation
    • Academy of Managed Care Pharmacy, May 18, Available from
    • Academy of Managed Care Pharmacy. AMCP Format for Formulary Submissions Version 2.1 Explanation. 2008 May 18. Available from:http://www.amcp.org/amcp.-ark?p=0F6E1295.
    • (2008)
  • 3
    • 0036078917 scopus 로고    scopus 로고
    • Health-related quality of life and cost impact of irritable bowel syndrome in a UK primary care setting
    • Akehurst, RL; Brazier, JE; Mathers, N; O'Keefe, C; Kaltenthaler, E; et al. Health-related quality of life and cost impact of irritable bowel syndrome in a UK primary care setting.Pharmacoeconomics, 2002; 20,455-62.
    • (2002) Pharmacoeconomics , vol.20 , pp. 455-462
    • Akehurst, R.L.1    Brazier, J.E.2    Mathers, N.3    O'Keefe, C.4    Kaltenthaler, E.5
  • 4
    • 0003821883 scopus 로고    scopus 로고
    • The Burden of Gastrointestinal Diseases
    • American Gastroenterological Association, Bethesda, MD:American Gastroenterological Association, 2008 May 15. Available from
    • American Gastroenterological Association. The Burden of Gastrointestinal Diseases. Bethesda, MD:American Gastroenterological Association; 2001. 2008 May 15. Available from:http://www.gastro.org/user-assets/Documents/burden-report.pdf.
    • (2001)
  • 5
    • 33745366578 scopus 로고    scopus 로고
    • Irritable bowel syndrome:recent and novel therapeutic approaches
    • Andresen, V; Camilleri, M. Irritable bowel syndrome:recent and novel therapeutic approaches. Drugs, 2006, 66, 1073-1088.
    • (2006) Drugs , vol.66 , pp. 1073-1088
    • Andresen, V.1    Camilleri, M.2
  • 8
    • 0031836946 scopus 로고    scopus 로고
    • Effects of kappa-opioid receptor agonists on responses to colorectal distension in rats with and without acute colonic inflammation
    • Burton, MB; Gebhart, GF. Effects of kappa-opioid receptor agonists on responses to colorectal distension in rats with and without acute colonic inflammation. J Pharmacology and Exp Ther, 1998, 285, 707-715.
    • (1998) J Pharmacology and Exp Ther , vol.285 , pp. 707-715
    • Burton, M.B.1    Gebhart, G.F.2
  • 9
    • 2442581507 scopus 로고    scopus 로고
    • Treating irritable bowel syndrome:overview, perspective and future therapies
    • Camilleri, M. Treating irritable bowel syndrome:overview, perspective and future therapies. Br J Pharmacol, 2004, 141, 1237-1248.
    • (2004) Br J Pharmacol , vol.141 , pp. 1237-1248
    • Camilleri, M.1
  • 11
    • 0032848856 scopus 로고    scopus 로고
    • Improvement in pain and bowel function in female patients with alosetron, a 5HT3 receptor antagonist
    • Camilleri, M; Mayer, EA; Drossman, DA; Heath, A; Dukes, GE; McSorley, D et al. Improvement in pain and bowel function in female patients with alosetron, a 5HT3 receptor antagonist. Aliment Pharmacol Ther, 1999, 13, 1149-1159.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 1149-1159
    • Camilleri, M.1    Mayer, E.A.2    Drossman, D.A.3    Heath, A.4    Dukes, G.E.5    McSorley, D.6
  • 12
    • 0034712539 scopus 로고    scopus 로고
    • Efficacy and safety of alosetron in women with irritable bowel syndrome:a randomized, placebocontrolled trial
    • Camilleri, M; Northcutt, AR; Kong, S; Dukes, GE; McSorley, D; Mangel, AW. Efficacy and safety of alosetron in women with irritable bowel syndrome:a randomized, placebocontrolled trial. Lancet, 2000, 355, 1035-1040.
    • (2000) Lancet , vol.355 , pp. 1035-1040
    • Camilleri, M.1    Northcutt, A.R.2    Kong, S.3    Dukes, G.E.4    McSorley, D.5    Mangel, A.W.6
  • 13
    • 0034917335 scopus 로고    scopus 로고
    • A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome
    • Camilleri, M; Chet, WY; Mayer, EA:Northcutt, AR; Heath, A; Dukes, GE; McSorley, D et al. A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med, 2001, 161, 1733-1740.
    • (2001) Arch Intern Med , vol.161 , pp. 1733-1740
    • Camilleri, M.1    Chet, W.Y.2    Mayer, E.A.3    Northcutt, A.R.4    Heath, A.5    Dukes, G.E.6    McSorley, D.7
  • 14
    • 19844368448 scopus 로고    scopus 로고
    • Total costs of IBS:employer and managed care perspective
    • Cash, B; Sullivan, S; Barghout, V. Total costs of IBS:employer and managed care perspective. Am J Manag Care, 2005, 11(1 Suppl), S7-S16.
    • (2005) Am J Manag Care , vol.11 , Issue.1 SUPPL
    • Cash, B.1    Sullivan, S.2    Barghout, V.3
  • 15
    • 18144378476 scopus 로고    scopus 로고
    • Brain responses to visceral and somatic stimuli in irritable bowel syndrome:a central nervous system disorder?
    • Chang, L. Brain responses to visceral and somatic stimuli in irritable bowel syndrome:a central nervous system disorder? Gastroenterol Clin N Am, 2005, 34, 271-279.
    • (2005) Gastroenterol Clin N Am , vol.34 , pp. 271-279
    • Chang, L.1
  • 16
    • 0032919603 scopus 로고    scopus 로고
    • Review article:an integrated approach to the irritable bowel syndrome
    • Drossman, DA. Review article:an integrated approach to the irritable bowel syndrome. Aliment Pharmacol Ther, 1999, 13, 3-14.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 3-14
    • Drossman, D.A.1
  • 17
    • 0030942155 scopus 로고    scopus 로고
    • The irritable bowel severity scoring system:a simple method of monitoring irritable bowel syndrome and its progress
    • Francis, CY; Morris, J; Whorwell PJ. The irritable bowel severity scoring system:a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther, 1997, 11, 395-402.
    • (1997) Aliment Pharmacol Ther , vol.11 , pp. 395-402
    • Francis, C.Y.1    Morris, J.2    Whorwell, P.J.3
  • 18
    • 0032216677 scopus 로고    scopus 로고
    • Health care utilization and economic issues in irritable bowel syndrome
    • Gralnek IM. Health care utilization and economic issues in irritable bowel syndrome. Eur JSurg Suppl, 1998, 73-76.
    • (1998) Eur JSurg , Issue.SUPPL , pp. 73-76
    • Gralnek, I.M.1
  • 19
    • 15444346837 scopus 로고    scopus 로고
    • Use of a novel electronic data collection system in multicenter trials of irritable bowel syndrome.
    • Harding, JP; Hamm, LR; Ehsanullah, RB; Heath, AT; . Sorrells, SC; Haw J; Dukes, et al. Use of a novel electronic data collection system in multicenter trials of irritable bowel syndrome. Aliment Pharm Ther 1997, 11, 1073-1076.
    • (1997) Aliment Pharm Ther , vol.11 , pp. 1073-1076
    • Harding, J.P.1    Hamm, L.R.2    Ehsanullah, R.B.3    Heath, A.T.4    Sorrells, S.C.5    Haw, J.D.6
  • 20
    • 0142027693 scopus 로고    scopus 로고
    • Systematic review:the economic impact of irritable bowel syndrome
    • Inadomi, JM; Fennerty, MB; Bjorkman, D. Systematic review:the economic impact of irritable bowel syndrome. Aliment Pharmacol Ther 2003, 18, 671-682.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 671-682
    • Inadomi, J.M.1    Fennerty, M.B.2    Bjorkman, D.3
  • 22
    • 40949131857 scopus 로고    scopus 로고
    • Clinical trial:phase 2 study of lubiprostone for irritable bowel syndrome with constipation
    • Johanson, JF; Drossman, DA; Panas, R; Wahle, A; Ueno, R. Clinical trial:phase 2 study of lubiprostone for irritable bowel syndrome with constipation. Aliment Pharmacol Ther, 2008, 27, 685-696.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 685-696
    • Johanson, J.F.1    Drossman, D.A.2    Panas, R.3    Wahle, A.4    Ueno, R.5
  • 23
    • 0037799916 scopus 로고    scopus 로고
    • An Asia-Pacific, double blind, placebo controlled, randomized study to evaluate the efficacy, safety and tolerability of tegaserod in patients with irritable bowel syndrome
    • Kellow, J; Lee, OY; Chang, FY; Thongsawat, S; Mazlam, MZ; Yuen, H et al. An Asia-Pacific, double blind, placebo controlled, randomized study to evaluate the efficacy, safety and tolerability of tegaserod in patients with irritable bowel syndrome. Gut, 2000 52, 671-676.
    • (2000) Gut , vol.52 , pp. 671-676
    • Kellow, J.1    Lee, O.Y.2    Chang, F.Y.3    Thongsawat, S.4    Mazlam, M.Z.5    Yuen, H.6
  • 24
    • 35348972498 scopus 로고    scopus 로고
    • The clinical and economic burden of irritable bowel syndrome
    • September supplement
    • Lembo, AJ. The clinical and economic burden of irritable bowel syndrome. Practical Gastroenterol, September supplement, 2007, 3-9.
    • (2007) Practical Gastroenterol , pp. 3-9
    • Lembo, A.J.1
  • 26
    • 37149041916 scopus 로고    scopus 로고
    • Clinical trial:dextofisopam in the treatment of patients with diarrhoea-predominant or alternating irritable bowel syndrome
    • Leventer, SM; Raudibaugh, K; Frissora, CL; Kassem, N; Keogh, JC; Phillips, J et al. Clinical trial:dextofisopam in the treatment of patients with diarrhoea-predominant or alternating irritable bowel syndrome. Aliment Pharmacol Ther, 2008, 27, 197-206.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 197-206
    • Leventer, S.M.1    Raudibaugh, K.2    Frissora, C.L.3    Kassem, N.4    Keogh, J.C.5    Phillips, J.6
  • 30
    • 0032918751 scopus 로고    scopus 로고
    • Review article:clinical pharmacology models of irritable bowel syndrome
    • Malagelada, JR. Review article:clinical pharmacology models of irritable bowel syndrome. Aliment Pharmacol Ther, 1999, 13, 57-64.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 57-64
    • Malagelada, J.R.1
  • 31
    • 1642492731 scopus 로고    scopus 로고
    • Study design issues in irritable bowel syndrome
    • Mangel, AW. Study design issues in irritable bowel syndrome. Aliment Pharmacol Ther, 2004, 19, 141-142.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 141-142
    • Mangel, A.W.1
  • 32
    • 33645051979 scopus 로고    scopus 로고
    • Personal view:adequate relief as a primary endpoint in irritable bowel syndrome
    • Mangel, AW. Personal view:adequate relief as a primary endpoint in irritable bowel syndrome. Aliment Pharmacol Ther, 2006, 23, 879-881.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 879-881
    • Mangel, A.W.1
  • 33
    • 28844439353 scopus 로고    scopus 로고
    • Global endpoints in functional gastrointestinal disease
    • Mangel, AW; Fehnel, SE. Global endpoints in functional gastrointestinal disease. Aliment Pharmacol Ther, 2005, 22, 1162-1163.
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 1162-1163
    • Mangel, A.W.1    Fehnel, S.E.2
  • 36
    • 0032922539 scopus 로고    scopus 로고
    • Review article:the safety and efficacy of alosetron, a 5HT3 receptor antagonist, in female irritable bowel syndrome patients
    • Mangel, AW; Northcutt, AR. Review article:the safety and efficacy of alosetron, a 5HT3 receptor antagonist, in female irritable bowel syndrome patients. Aliment Pharmacol Ther, 1999, 13, 77-82.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 77-82
    • Mangel, A.W.1    Northcutt, A.R.2
  • 37
    • 0344413667 scopus 로고    scopus 로고
    • Utilization patterns and net direct medical cost to Medicaid of irritable bowel syndrome
    • Martin, BC; Ganguly, R; Pannicker, S; Frech, F; Barghout, V. Utilization patterns and net direct medical cost to Medicaid of irritable bowel syndrome. Curr Med Res Opin, 2003, 19(8), 771-780.
    • (2003) Curr Med Res Opin , vol.19 , Issue.8 , pp. 771-780
    • Martin, B.C.1    Ganguly, R.2    Pannicker, S.3    Frech, F.4    Barghout, V.5
  • 39
    • 42249114703 scopus 로고    scopus 로고
    • Irritable bowel syndrome
    • Mayer, EA. Irritable bowel syndrome. N Eng J Med, 2008, 358, 1692-1699.
    • (2008) N Eng J Med , vol.358 , pp. 1692-1699
    • Mayer, E.A.1
  • 41
    • 0034794595 scopus 로고    scopus 로고
    • Tegaserod, a 5HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation
    • Muller-Lissner, SA; Fumagalli, I; Bardhan, KD; Pace, F; Pecher, E; Nault, B; et al. Tegaserod, a 5HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Aliment Pharmacol Ther, 2001, 15, 1655-1666.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1655-1666
    • Muller-Lissner, S.A.1    Fumagalli, I.2    Bardhan, K.D.3    Pace, F.4    Pecher, E.5    Nault, B.6
  • 42
    • 0036829638 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndromw with constipation
    • Novick, L, Miner, P, Krause, R, Glebas, K, Bliesath, H, Ligozio, G, et al. A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndromw with constipation. Aliment Pharmacol Ther, 2002, 16, 1877-1888.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1877-1888
    • Novick, L.1    Miner, P.2    Krause, R.3    Glebas, K.4    Bliesath, H.5    Ligozio, G.6
  • 43
    • 0032919604 scopus 로고    scopus 로고
    • Review article:evaluation of drugs in experimental gut distension models
    • Pappas, TN; Mangel, AW; Lawson, CL. Review article:evaluation of drugs in experimental gut distension models. Aliment Pharmacol Ther, 1999, 13(suppl 2), 54-56.
    • (1999) Aliment Pharmacol Ther , vol.13 , Issue.2 SUPPL , pp. 54-56
    • Pappas, T.N.1    Mangel, A.W.2    Lawson, C.L.3
  • 45
    • 33846312797 scopus 로고    scopus 로고
    • The relationship between dosing of alosetron and discontinuation patterns reported by patients participating in a follow-up program
    • Tennis, P; Andrews, E; Hickman, P; Miller, D; Hollis, K, Cook, S. The relationship between dosing of alosetron and discontinuation patterns reported by patients participating in a follow-up program. Aliment Pharmacol Ther, 2007, 25, 317-322.
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 317-322
    • Tennis, P.1    Andrews, E.2    Hickman, P.3    Miller, D.4    Hollis, K.5    Cook, S.6
  • 46
    • 33746261692 scopus 로고    scopus 로고
    • Food and Drug Administration.CDER2002193, docket no. 2006D-0044, Guidance for Industry Patient-Reported Outcome Measures:Use in Medical Product Development to Support Labeling Claims Draft Guidance
    • US Department of Health and Human Services, 2008. Available from
    • US Department of Health and Human Services. Food and Drug Administration.CDER2002193, docket no. 2006D-0044, Guidance for Industry Patient-Reported Outcome Measures:Use in Medical Product Development to Support Labeling Claims Draft Guidance. 2006. 2008. Available from:http://www.fda.gov/cder/-guidance/5460dft.pdf.
    • (2006)
  • 47
    • 0035123901 scopus 로고    scopus 로고
    • Alosetron improves quality of life in women with diarrhea-predominant irritable bowel syndrome
    • Watson, ME; Lacey, L; Kong, S; Northcutt, AR; McSorley, D; Hahn, B; Mangel, AW. Alosetron improves quality of life in women with diarrhea-predominant irritable bowel syndrome. Am J Gastro, 2001, 96, 455-459.
    • (2001) Am J Gastro , vol.96 , pp. 455-459
    • Watson, M.E.1    Lacey, L.2    Kong, S.3    Northcutt, A.R.4    McSorley, D.5    Hahn, B.6    Mangel, A.W.7
  • 48
    • 2542589387 scopus 로고    scopus 로고
    • Absenteeism among employees with irritable bowel syndrome
    • Zacker, C; Chawla, AJ; Wang, S; Albers, LA. Absenteeism among employees with irritable bowel syndrome. Manag Care Interface, 2004, 17(5), 28-32.
    • (2004) Manag Care Interface , vol.17 , Issue.5 , pp. 28-32
    • Zacker, C.1    Chawla, A.J.2    Wang, S.3    Albers, L.A.4


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