Inactivation of DNA-Dependent Protein Kinase Promotes Heat-Induced Apoptosis Independently of Heat-Shock Protein Induction in Human Cancer Cell Lines

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Okazawa, Seisuke ^a   Furusawa, Yukihiro ^a   Kariya, Ayako ^a   Hassan, Mariame Ali ^a,b   Arai, Mie ^a   Hayashi, Ryuji ^a   Tabuchi, Yoshiaki ^a   Kondo, Takashi ^a   Tobe, Kazuyuki ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

[2 (MORPHOLIN 4 YL) BENZO[H]CHOMEN 4 ONE]; [8 (4 DIBENZOTHIENYL) 2 (4 MORPHOLINYL) 4H 1 BENZOPYRAN 4 ONE]; CELL PROTEIN; DNA DEPENDENT PROTEIN KINASE; EARLY GROWTH RESPONSE FACTOR 2; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; NUCLEAR RECEPTOR NR1D1; PROTEIN C JUN; PROTEIN SERINE THREONINE KINASE INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BATH; CANCER CELL CULTURE; CELL STRESS; EGR2 GENE; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GENETIC NETWORK ANALYSIS; GENETIC PROCEDURES; HEAT INDUCED APOPTOSIS; HEAT STRESS; HSP GENE; HUMAN; HUMAN CELL; JUN GENE; MICROARRAY ANALYSIS; NR1D1 GENE; PROTEIN EXPRESSION; PROTEIN INDUCTION; RNA EXTRACTION; THERMAL EXPOSURE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; DNA DAMAGE; DNA-ACTIVATED PROTEIN KINASE; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENE SILENCING; HEAT-SHOCK PROTEINS; HOT TEMPERATURE; HUMANS; PROTEIN KINASE INHIBITORS; REPRODUCIBILITY OF RESULTS; RNA INTERFERENCE;

EID: 84874844621     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058325     Document Type: Article

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