NMR Derivatives for quantification of 2H and 13C-enrichment of human glucuronide from metabolic tracers

Journal of Carbohydrate Chemistry

Volumn 25, Issue 2-3, 2006, Pages 203-217

  Jones, John ^a   Barosa, Cristina ^a   Gomes, Filipe ^b   Carina Mendes, Ana ^b   Delgado, Teresa ^a   Diogo, Luisa ^c   Garcia, Paula ^c   Bastos, Margarida ^c   Barros, Luisa ^c   Fagulha, Ana ^c   Baptista, Carla ^c   Carvalheiro, Manuela ^c   Madalena Caldeira, M ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

Author keywords

Gluconeogenesis; Glycogen; Intermediary metabolism; Isotopomers; Liver

Indexed keywords

EID: 33745133402     PISSN: 07328303     EISSN: 15322327     Source Type: Journal    
DOI: 10.1080/07328300600732840     Document Type: Conference Paper

References (22)

1. 13C-labeling pattern of glucose by gas chromatography-mass spectrometry. Anal. Biochem. 1993, 212, 526-531.
2. Peroni, O.; Large, V.; Diraison, F.; Beylot, M. Glucose production and gluconeogenesis in postabsorptive and starved normal and streptozotocin-diabetic rats. Metabolism 1997, 46, 1358-1363.
3. Hellerstein, M.K.; Neese, R.A.; Linfoot, P.; Christiansen, M.; Turner, S.; Letscher, A. Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. J. Clin. Invest. 1997, 100, 1305-1319.
4. 13C NMR study of gluconeogenesis and TCA cycle flux in humans. Am. J. Physiol. 2001, 281, E848-E851.
5. Landau, B.R.; Wahren, J.; Chandramouli, V.; Schumann, W.C.; Ekberg, K.; Kalhan, S.C. Contributions of gluconeogenesis to glucose production in the fasted state. J. Clin. Invest. 1996, 98, 378-385.
6. Tayek, J.A.; Katz, J. Glucose production, recycling, Cori cycle, and gluconeogenesis in humans: relationship to serum cortisol. Am. J. Physiol. 1997, 272, E476-E484.
7. 13C NMR isotopomer analysis of human urine. Anal. Biochem. 2003, 312, 228-234.
8. 2O for quantification of hepatic glucose production and gluconeogenesis. NMR Biomed. 2003, 16, 189-198.
9. Schleucher, J.; Vanderveer, P.J.; Sharkey, T.D. Export of carbon from chloroplasts at night. Plant Physiol. 1998, 118, 1439-1445.
10. Schleucher, J.; Vanderveer, P.; Markley, J.L.; Sharkey, T.D. Intramolecular deuterium distributions reveal disequilibrium of chloroplast phosphoglucose isomerase. Plant Cell Environ. 1999, 22, 525-533.
11. Ekberg, K.; Chandramouli, V.; Kumaran, K.; Schumann, W.C.; Wahren, J.; Landau, B.R. Gluconeogenesis and glucuronidation in liver in vivo and the heterogeneity of hepatocyte function. J. Biol. Chem. 1995, 270, 21715-21717.
12. Hellerstein, M.K.; Greenblatt, D.J.; Munro, H.N. Glycoconjugates as noninvasive probes of intrahepatic metabolism - pathways of glucose entry into compartmentalized hepatic UDP-glucose pools during glycogen accumulation. Proc. Natl. Acad. Sci. USA 1986, 83, 7044-7048.
13. 13C]propionate, phenylacetate, and acetaminophen. Am. J. Physiol. 1998, 275, E843-E852.
14. 2O for estimating rates of gluconeogenesis. Application to the fasted state. J. Clin. Invest. 1995, 95, 172-178.
15. Baba, H.; Zhang, X.J.; Wolfe, R.R. Glycerol gluconeogenesis in fasting humans. Nutrition 1995, 11, 149-153.
16. 1H NMR analysis of the lactate methyl signal. Magn. Res. Med. 2004, 51, 1283-1286.
17. 2]glucose as a tracer for glucose turnover by nuclear magnetic resonance. Magn. Res. Med. 2005, 53, 1479-1483.
18. 2H NMR analysis of plasma glucose. Biochim. Biophys. Acta 2003, 1637, 156-163.
19. 2H NMR analysis of its monoacetone derivative. Magn. Res. Med. 2002, 48, 535-539.
20. Jin, E.S.; Jones, J.G.; Merritt, M.; Burgess, S.C.; Malloy, C.R.; Sherry, A.D. Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative. Anal. Biochem. 2004, 327, 149-155.
21. 2O. Magn. Res. Med. 2005, 54, 429-434.
22. Freeman, R. Spin Choreography; Oxford University Press: New York, 1997; 314-333.